Protein Domain : VPRBP/DCAF1 family IPR033270

Type  Family
Description  This entry represents the VPRBP/DCAF1 family, whose members include protein VPRBP from mammals [ ], protein mahjong form fruit flies [] and DCAF1 from worms and plants []. They are the substrate recognition component of the E3 ubiquitin-protein ligase complex. Human VPRBP is part of the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that mediates ubiquitination and proteasome-dependent degradation of proteins [ ]. VPRBP also has kinase activity and is capable of phosphorylating histone H2A on threonine 120 (H2AT120p) in a nucleosomal context [].
Short Name  VPRBP/DCAF1

0 Child Features

0 Gene Families

0 Genes

1 Ontology Annotations

0 Parent Features

0 Publications

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