LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | This entry represents YcgR a member of the T3SS. It acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Increasing levels of c-di-GMP lead to decreased motility. YcgR binds 1 c-di-GMP dimer per subunit. YcgR is composed of two domains: an N-terminal domain of unknown function and a C-terminal PilZ domain. The PilZ domain binds c-di-GMP in vitro with an affinity that is high enough to allow it to respond to small changes in intracellular c-di-GMP levels. This domain organisation is conserved in a large number of proteobacteria. Therefore, the function of YcgR in motility control is likely to be conserved. Higher concentrations of c-di-GMP in the presence of YcgR slows motor speed and inhibit chemotaxis by inhibiting ClockWise (CW) rotation. YcgR, when bound to c-di-GMP, interacts strongly with the flagellar motor proteins FliG and FliM. Interaction with FliG disrupts the organisation of the C-terminal domain altering the rotor-stator interface in a way that reduces the efficiency of torque generation and induces a CCW motor bias [ ]. |
| Short Name | T3SS_YcgR |
