Protein Domain : 3'-5' exoribonuclease Rv2179c-like domain IPR033390

Type	Domain
Description	This entry represents a domain found in a group of divergent 3' exoribonucleases. The proteins constitute a typical RNase fold, where the active site residues form a magnesium catalytic centre. The protein of the solved structure readily cleaves 3' overhangs in a time-dependent manner. It is similar to DEDD-type RNases and is an unusual ATP-binding protein that binds ATP and dATP. It forms a dimer in solution and both protomers in the asymmetric unit bind a magnesium ion through Asp-6 [ ].Proteins containing this domain also include 3'-5' exonuclease dexA from bacteriophage T4. It may play a role in the final step of host DNA degradation, by scavenging DNA into mononucleotides [ , ].
Short Name	Rv2179c-like