Protein Domain : Scaffold protein Ste5, Fus3-binding domain IPR021651

Type  Domain
Description  This entry represents the Fus3 binding domain of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mitogen-activated protein kinase. Auto-activated Fus3 has a negative regulatory role, and promotes Ste5 phosphorylation which leads to a decrease in pathway transcriptional output [].
Short Name  Ste5_Fus-binding

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1 Ontology Annotations

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