Protein Domain : Thoeris protein ThsA, Macro domain IPR045535

Type	Domain
Description	Thoeris is a bacterial antiphage defense system, which consists of two genes, thsA and thsB, via NAD+ degradation [ , , ]. ThsA has robust NAD+ cleavage activity and and a two-domain architecture containing a N-terminal NAD-binding domain (denoted as sirtuin-like or Macro) and C-terminal SLOG-like domain. In some instances, such as in B. amyloliquefaciens, ThsA has an N-terminal transmembrane domain []. ThsB (also referred to as TIR1 and TIR2) is structurally similar to TIR domain proteins but without enzymatic activity.This entry represents the C-terminal Macro domain of ThsA from B. amyloliquefaciens, which adopts a Rossmann-like fold and binds NAD+ [, , ].
Short Name	ThsA_Macro