Protein Domain : Pilin-like IPR045584

Type	Homologous_superfamily
Description	This superfamily includes Pilin and related proteins, such as general secretion pathway protein G (GSPG) and autotransporter adhesin YadA-like proteins.Pilin is a component of type IV pilus (T4P), a polar flexible filament, which consists of a single polypeptide chain arranged in a helical configuration of five subunits per turn, which is involved cell adhesion, microcolony formation, twitching motility and transformation [ , ]. Gram-negative bacteria produce pilin which is characterised by the presence of a very short leader peptide of 6 to 7 residues, followed by a methylated N-terminal phenylalanine residue and by a highly conserved sequence of about 24 hydrophobic residues, of the NMePhe type pilin [, ].GSPG shares several sequence similarities with bacterial fimbrial protein, or pilin, the major structural protein of pili [ , ]. Pili are polar flexible filamentous adhesions ~2500 nm in length, and diameter ~5.4 nm. Fimbrial and GSPG proteins share the following characteristics: a methylated, hydrophobic N-terminal residue; a hydrophobic leader peptide of 5-10 residues, terminating with glycine; glutamate as the fifth residue of the mature sequence; and a highly hydrophobic N-terminal. This system is homologous to the type IV pilus biogenesis and includes different proteins, termed psudopilins, which are structurally homologous to the type IV pilins [, ].Autotransporter adhesin YadA-like proteins are part of a class of pathogenicity factors that act as cell surface adhesion molecules, in which N-terminal head and neck domains extend from the bacterial outer membrane [ ].
Short Name	Pilin-like