Protein Domain : Retrograde transport protein Dsl1, C-terminal domain IPR021876

Type	Domain
Description	Dsl1 is a peripheral membrane protein part of the DSL1 complex, required for transport between the Golgi and the endoplasmic reticulum [ , ]. It is localised to the ER membrane, and bridges the other two subunits of the complex, Tip20 and Sec39. DSL1 complex, together with conserved oligomeric Golgi (COG), Golgi-associated retrograde protein (GARP), and the exocyst, is a member of the complexes associated with tethering containing helical rods (CATCHR) family, which are evolutionary related and share structural features []. This complex interacts at its base with ER SNAREs and at its tip with COPI vesicles, thus, it captures Golgi-derived COP-I vesicles and facilitates their fusion with the ER the Dsl1 complex, upstream of SNARE complex formation [, , ]. The C-terminal domain is involved in binding to the Sec39 subunit of the Dsl1p complex [, ]. The N-terminal complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein [].
Short Name	Dsl1_C