Protein Domain : Pre-mRNA-splicing regulator WTAP IPR033757

Type	Family
Description	Pre-mRNA-splicing regulator WTAP (Wilms' tumor 1-associating protein) is a regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) formation, which acts as an epitranscriptomic marker [ , ]. It plays a role in the efficiency of mRNA splicing and processing, and mRNA stability []. In Drosophila, the homologous protein pfemale-lethal(2)D has been implicated in alternative splicing regulation of genes involved in sexual determination [] and is required for eye development []. FKBP12-interacting protein of 37kDa (AtFIP37, At3g54170), the homologue from Arabidopsis, may also have a role in splicing events []. AtFIP37 interacts with mRNA adenosine methylase (MTA, encoded by At4g10760) in vitro and in vivo [].
Short Name	WTAP