Protein Domain : BTB/POZ domain-containing protein KCTD11/21, C-terminal domain IPR045763

Type  Domain
Description  This entry represents the C-terminal region of BTB/POZ domain-containing protein KCTD11 (the KCASH1 protein, also known as REN: EGF-, NGF- and retinoic acid-responsive gene) and its homologue, KCTD21 (the KCASH2 protein).These members of the KCASH family (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog) share high similarity and a BTB domain responsible for oligomerization and formation of a Cullin3 ubiquitin ligase complex. They are specifically expressed in brain and cerebellum where they have a role in neuronal differentiation, and suppressor activity on acetylation-dependent Hedgehog/Gli signalling through ubiquitination and degradation of histone deacetylase 1 (HDAC1). These proteins have been described as tumor suppressors that inhibit medulloblastoma growth by antagonizing Hedgehog signalling [ , , ].
Short Name  KCTD11/21_C
Paste the following link
Lists
This ProteinDomain isn't in any lists. Upload a list.

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

0 Parent Features

0 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom