Protein Domain : Major vault protein repeat domain 2 superfamily IPR043179

Type	Homologous_superfamily
Description	The vault complex is the largest ribonucleoprotein particle found in eukaryotes [ ]. Although several functions have been proposed for vaults since their discovery in 1986, including roles in multidrug resistance, cell signaling, and innate immunity, their cellular function remains unclear []. In mammals, vaults contain three proteins: the 100kDa major vault protein (MVP), the 193kDa vault poly(ADP-ribosyl)ating polymerase VPARP and the 240kDa telomerase-associated protein TEP1. Approximately 75% of the vault particle mass is due to MVP []. The MVP monomer folds to form structural repeat domains at the N terminus, a shoulder domain, a cap-helix and cap-ring domains.This superfamily represents the major vault protein repeat domain 2, found at the N terminus.
Short Name	Vault_2_sf