Protein Domain : Arginine-tRNA-protein transferase 1, eukaryotic IPR017137

Type	Family
Description	Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis [ ]. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity []. Of these, only Cys 94 appears to be completely conserved in this family. This entry represents eukaryotic type arginyl-tRNA--protein transferase 1 ( ) [ ].
Short Name	Arg-tRNA-P_Trfase_1_euk