Protein Domain : Paraneoplastic encephalomyelitis antigen IPR002343

Type	Family
Description	Many eukaryotic proteins that are either known or thought to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids [, ]. This region has been found in, for example,heterogeneous nuclear ribonucleoproteins, small nuclear ribonucleoproteins, pre-RNA and mRNA associated proteins, Drosophila sex determination and elavproteins, human paraneoplastic encephalomyelitis antigen HuD, and many others.The structure of an RNA-binding domain of Drosophila Sex-lethal (Sxl) protein has been determined using multi-dimensional hetero-nuclear NMR [].Sxl contains two RNP consensus-type RNA-binding domains (RBDs) - the determined structure represents the second of these (RBD-2) []. Thecalculated intermediate-resolution family of structures exhibits the beta-α-β/beta-α-β tertiary fold found in other RBD-containingproteins [ ].
Short Name	Hud_Sxl_RNA