Protein Domain : Sterol-sensing domain IPR000731

Type  Domain
Description  The sterol-sensing domain (SSD) is an around 180 residues long cluster of five membrane-spanning segments. The SSD domain is conserved across phyla andconfers sensitivity to regulation by sterol. Although the SSD domain appears to function as a regulatory domain involved in linking vesicle trafficking andprotein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis, its exact mode of action is not clear. It isnot known whether it interacts with sterols, such as cholesterol, or whether it interacts with another-sterol regulated protein. Alternatively, the SSD mayinteract with lipids other than cholesterol [ , , ].In addition to the proteins above, the SSD is also found in a number of bacterial drug resistance proteins.
Short Name  SSD

0 Child Features

0 Gene Families

11 Genes

0 Ontology Annotations

0 Parent Features

3 Publications

USDA
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