Protein Domain : CobW/HypB/UreG, nucleotide-binding domain IPR003495

Type	Domain
Description	This domain is found in HypB, a hydrogenase expression/formation protein, and urease accessory protein UreG. Both these proteins contain a P-loop nucleotide binding motif [ , ]. HypB has GTPase activity and is a guanine nucleotide binding protein []. UreG is a GTPase in charge of nucleotide hydrolysis required for activation of the urease enzyme []. Both GTPases are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression []. UreG is required for functional incorporation of the urease nickel metallocentre []. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins [].Other proteins containing this domain include P47K ( ), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, CobW ( ), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans [ ], and YjiA []. Both CobW and YjiA are members of the metal homeostasis-associated COG0523 family of GTPases [].
Short Name	CobW/HypB/UreG_dom