Protein Domain : Nucleoprotein TPR/MLP1 IPR012929

Type  Domain
Description  This domain is found in a number of proteins, including TPR protein ( ) and yeast myosin-like protein 1 (MLP1, ). These proteins share a number of features; for example, they have coiled-coil regions and are associated with nuclear pores [ , , ]. TPR is thought to be a component of nuclear pore complex- attached intranuclear filaments [], and is implicated in nuclear protein import []. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex []. Mlp1 acts as a docking platform for for heterogeneous nuclear ribonucleoproteins that are required for mRNA export [].
Short Name  TPR/MLP1

0 Child Features

1 Gene Families

6 Genes

1 Ontology Annotations

0 Parent Features

4 Publications

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