Protein Domain : APC10/DOC domain IPR004939

Type	Domain
Description	The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [ ].One of the subunits of the APC that is required for ubiquitination activity is APC10, a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see ), cullin (see ) or HECT (see ) domains [ , , ].The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold [, ].Proteins known to contain a DOC domain include: Eucaryotic Doc1/Apc10.Mammalian protein associated with the transcription factor Myc (PAM).Mouse runty-jerky-sterile (RJS) protein.Human HERC2, the ortholog of RJS.
Short Name	APC_su10/DOC_dom