Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, pathways, authors, ontology terms, etc. (e.g. eve, embryo, zen, allele)
  • Use OR to search for either of two terms (e.g. fly OR drosophila) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. dros* for partial matches or fly AND NOT embryo to exclude a term

Search results 2001 to 2100 out of 6162 for seed protein

Category restricted to GOTerm (x)

<< First    < Previous  |  Next >    Last >>
0.042s

Categories

Category: GOTerm
« show all
Type Details Score
GO Term
GO:0007196 | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
•
•
•
•
•
GO Term
GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
•
•
•
•
•
GO Term
GO:0007206 | phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
•
•
•
•
•
GO Term
GO:0007207 | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
•
•
•
•
•
GO Term
GO:0009977 | proton motive force dependent protein transmembrane transporter activity
Description: Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane.
•
•
•
•
•
GO Term
GO:0010619 | adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
Description: The series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
•
•
•
•
•
GO Term
GO:0018058 | N-terminal protein amino acid deamination, from amino carbon
Description: The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol.
•
•
•
•
•
GO Term
GO:0018163 | protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine
Description: The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine.
•
•
•
•
•
GO Term
GO:0018355 | protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine
Description: The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine.
•
•
•
•
•
GO Term
GO:0019060 | intracellular transport of viral protein in host cell
Description: The directed movement of a viral protein within the host cell.
•
•
•
•
•
GO Term
GO:0019801 | cyclization of asparagine involved in intein-mediated protein splicing
Description: The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing.
•
•
•
•
•
GO Term
GO:0019802 | cyclization of glutamine involved in intein-mediated protein splicing
Description: The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing.
•
•
•
•
•
GO Term
GO:0023028 | MHC class I protein binding, via lateral surface
Description: Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface.
•
•
•
•
•
GO Term
GO:0023031 | MHC class Ib protein binding, via lateral surface
Description: Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface.
•
•
•
•
•
GO Term
GO:0031364 | N-terminal protein amino acid deamination, from side chain
Description: The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein.
•
•
•
•
•
GO Term
GO:0032803 | regulation of low-density lipoprotein particle receptor catabolic process
Description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.
•
•
•
•
•
GO Term
GO:0070303 | negative regulation of stress-activated protein kinase signaling cascade
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
•
•
•
•
•
GO Term
GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
•
•
•
•
•
GO Term
GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein
Description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
•
•
•
•
•
GO Term
GO:0033662 | modulation by symbiont of host defense-related protein level
Description: The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
•
•
•
•
•
GO Term
GO:1905170 | negative regulation of protein localization to phagocytic vesicle
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle.
•
•
•
•
•
GO Term
GO:0038035 | G protein-coupled receptor signaling in absence of ligand
Description: A series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist.
•
•
•
•
•
GO Term
GO:0039584 | suppression by virus of host protein kinase activity
Description: Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity.
•
•
•
•
•
GO Term
GO:0039647 | suppression by virus of host poly(A)-binding protein activity
Description: Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation.
•
•
•
•
•
GO Term
GO:0039649 | modulation by virus of host ubiquitin-protein ligase activity
Description: The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
•
•
•
•
•
GO Term
GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
•
•
•
•
•
GO Term
GO:0042657 | MHC class II protein binding, via lateral surface
Description: Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules.
•
•
•
•
•
GO Term
GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
•
•
•
•
•
GO Term
GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process
Description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
•
•
•
•
•
GO Term
GO:0042996 | regulation of Golgi to plasma membrane protein transport
Description: Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
•
•
•
•
•
GO Term
GO:1903077 | negative regulation of protein localization to plasma membrane
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
•
•
•
•
•
GO Term
GO:1904376 | negative regulation of protein localization to cell periphery
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.
•
•
•
•
•
GO Term
GO:1903078 | positive regulation of protein localization to plasma membrane
Description: Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
•
•
•
•
•
GO Term
GO:1904377 | positive regulation of protein localization to cell periphery
Description: Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.
•
•
•
•
•
GO Term
GO:0044031 | modification by symbiont of host protein by phosphorylation
Description: The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
•
•
•
•
•
GO Term
GO:0044315 | protein secretion by the type VII secretion system
Description: The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system.
•
•
•
•
•
GO Term
GO:0044870 | modulation by host of viral glycoprotein metabolic process
Description: A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process.
•
•
•
•
•
GO Term
GO:0045167 | asymmetric protein localization involved in cell fate determination
Description: Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
•
•
•
•
•
GO Term
GO:0045326 | protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine
Description: The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine.
•
•
•
•
•
GO Term
GO:0045714 | regulation of low-density lipoprotein particle receptor biosynthetic process
Description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.
•
•
•
•
•
GO Term
GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway
Description: Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
•
•
•
•
•
GO Term
GO:0046819 | protein secretion by the type V secretion system
Description: The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway.
•
•
•
•
•
GO Term
GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade
Description: Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
•
•
•
•
•
GO Term
GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
•
•
•
•
•
GO Term
GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein
Description: Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
•
•
•
•
•
GO Term
GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane
Description: The directed movement of a protein to a specific location in the endoplasmic reticulum membrane.
•
•
•
•
•
GO Term
GO:0098777 | protein secretion by the type VIII secretion system
Description: Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits.
•
•
•
•
•
GO Term
GO:0098790 | ncRNA transcription associated with protein coding gene TSS/TES
Description: The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes.
•
•
•
•
•
GO Term
GO:0098841 | protein localization to cell division site after cytokinesis
Description: A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis.
•
•
•
•
•
GO Term
GO:0099019 | maintenance of protein localization at growing cell tip
Description: Any process in which localization of a protein is maintained at the growing cell tip.
•
•
•
•
•
GO Term
GO:0099105 | ion channel modulating, G protein-coupled receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel.
•
•
•
•
•
GO Term
GO:0099109 | potassium channel activating, G protein-coupled receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel.
•
•
•
•
•
GO Term
GO:1990896 | protein localization to cell cortex of cell tip
Description: A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip.
•
•
•
•
•
GO Term
GO:1905749 | regulation of endosome to plasma membrane protein transport
Description: Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport.
•
•
•
•
•
GO Term
GO:1900455 | regulation of flocculation via cell wall protein-carbohydrate interaction
Description: Any process that modulates the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction.
•
•
•
•
•
GO Term
GO:0102554 | lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein
Description: Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]
•
•
•
•
•
GO Term
GO:1901900 | regulation of protein localization to cell division site
Description: Any process that modulates the frequency, rate or extent of protein localization to cell division site.
•
•
•
•
•
GO Term
GO:1904778 | positive regulation of protein localization to cell cortex
Description: Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.
•
•
•
•
•
GO Term
GO:0106012 | positive regulation of protein localization to medial cortex
Description: Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex.
•
•
•
•
•
GO Term
GO:0120046 | regulation of protein localization to medial cortical node
Description: Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node.
•
•
•
•
•
GO Term
GO:0140052 | cellular response to oxidised low-density lipoprotein particle stimulus
Description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
•
•
•
•
•
GO Term
GO:0140325 | negative regulation of protein localization to medial cortex
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex.
•
•
•
•
•
GO Term
GO:1904777 | negative regulation of protein localization to cell cortex
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex.
•
•
•
•
•
GO Term
GO:0150107 | positive regulation of protein localization to cell-cell junction
Description: Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.
•
•
•
•
•
GO Term
GO:1900102 | negative regulation of endoplasmic reticulum unfolded protein response
Description: Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
•
•
•
•
•
GO Term
GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response
Description: Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
•
•
•
•
•
GO Term
GO:1900484 | negative regulation of protein targeting to vacuolar membrane
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane.
•
•
•
•
•
GO Term
GO:1900485 | positive regulation of protein targeting to vacuolar membrane
Description: Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane.
•
•
•
•
•
GO Term
GO:1903747 | regulation of establishment of protein localization to mitochondrion
Description: Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion.
•
•
•
•
•
GO Term
GO:1901308 | regulation of sterol regulatory element binding protein cleavage
Description: Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage.
•
•
•
•
•
GO Term
GO:1902993 | positive regulation of amyloid precursor protein catabolic process
Description: Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.
•
•
•
•
•
GO Term
GO:1902363 | regulation of protein localization to spindle pole body
Description: Any process that modulates the frequency, rate or extent of protein localization to spindle pole body.
•
•
•
•
•
GO Term
GO:1902992 | negative regulation of amyloid precursor protein catabolic process
Description: Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process.
•
•
•
•
•
GO Term
GO:1902966 | positive regulation of protein localization to early endosome
Description: Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
•
•
•
•
•
GO Term
GO:1903068 | positive regulation of protein localization to cell tip
Description: Any process that activates or increases the frequency, rate or extent of protein localization to cell tip.
•
•
•
•
•
GO Term
GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process
Description: Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.
•
•
•
•
•
GO Term
GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process
Description: Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.
•
•
•
•
•
GO Term
GO:1903394 | protein localization to kinetochore involved in kinetochore assembly
Description: Any protein localization to kinetochore that is involved in kinetochore assembly.
•
•
•
•
•
GO Term
GO:1903418 | protein localization to plasma membrane of cell tip
Description: A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip.
•
•
•
•
•
GO Term
GO:1903445 | protein transport from ciliary membrane to plasma membrane
Description: The directed movement of protein from ciliary membrane to plasma membrane.
•
•
•
•
•
GO Term
GO:1903568 | negative regulation of protein localization to ciliary membrane
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane.
•
•
•
•
•
GO Term
GO:1903569 | positive regulation of protein localization to ciliary membrane
Description: Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.
•
•
•
•
•
GO Term
GO:1903636 | regulation of protein import into mitochondrial outer membrane
Description: Any process that modulates the frequency, rate or extent of protein import into mitochondrial outer membrane.
•
•
•
•
•
GO Term
GO:1903922 | negative regulation of protein processing in phagocytic vesicle
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle.
•
•
•
•
•
GO Term
GO:1903923 | positive regulation of protein processing in phagocytic vesicle
Description: Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle.
•
•
•
•
•
GO Term
GO:1903995 | regulation of non-membrane spanning protein tyrosine kinase activity
Description: Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
•
•
•
•
•
GO Term
GO:1904152 | regulation of retrograde protein transport, ER to cytosol
Description: Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol.
•
•
•
•
•
GO Term
GO:1904216 | positive regulation of protein import into chloroplast stroma
Description: Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma.
•
•
•
•
•
GO Term
GO:1904324 | negative regulation of inhibitory G protein-coupled receptor phosphorylation
Description: Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.
•
•
•
•
•
GO Term
GO:1904325 | positive regulation of inhibitory G protein-coupled receptor phosphorylation
Description: Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.
•
•
•
•
•
GO Term
GO:1904350 | regulation of protein catabolic process in the vacuole
Description: Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole.
•
•
•
•
•
GO Term
GO:1904370 | regulation of protein localization to actin cortical patch
Description: Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch.
•
•
•
•
•
GO Term
GO:1904378 | maintenance of unfolded protein involved in ERAD pathway
Description: Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome.
•
•
•
•
•
GO Term
GO:1904508 | regulation of protein localization to basolateral plasma membrane
Description: Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane.
•
•
•
•
•
GO Term
GO:1904702 | regulation of protein localization to cell-cell adherens junction
Description: Any process that modulates the frequency, rate or extent of protein localization to cell-cell adherens junction.
•
•
•
•
•
GO Term
GO:1904870 | negative regulation of protein localization to Cajal body
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body.
•
•
•
•
•
GO Term
GO:1904871 | positive regulation of protein localization to Cajal body
Description: Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.
•
•
•
•
•
GO Term
GO:1905171 | positive regulation of protein localization to phagocytic vesicle
Description: Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle.
•
•
•
•
•
GO Term
GO:1905551 | negative regulation of protein localization to endoplasmic reticulum
Description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum.
•
•
•
•
•
GO Term
GO:1905552 | positive regulation of protein localization to endoplasmic reticulum
Description: Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum.
•
•
•
•
•
USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom