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Search results 3001 to 3100 out of 6162 for seed protein

Category restricted to GOTerm (x)

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Category: GOTerm
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Type Details Score
GO Term
GO:0031461 | cullin-RING ubiquitin ligase complex
Description: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
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GO Term
GO:0009317 | acetyl-CoA carboxylase complex
Description: A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex.
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GO Term
GO:0001405 | PAM complex, Tim23 associated import motor
Description: Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.
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GO Term
GO:0000125 | PCAF complex
Description: A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
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GO Term
GO:0001010 | RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
Description: The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
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GO Term
GO:0019029 | helical viral capsid
Description: The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure.
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GO Term
GO:0030085 | PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
Description: A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides.
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GO Term
GO:0033257 | Bcl3/NF-kappaB2 complex
Description: A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription.
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GO Term
GO:0033328 | peroxisome membrane targeting sequence binding
Description: Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane.
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GO Term
GO:0035877 | death effector domain binding
Description: Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).
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GO Term
GO:0044609 | DBIRD complex
Description: A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD.
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GO Term
GO:0046696 | lipopolysaccharide receptor complex
Description: A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.
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GO Term
GO:1990345 | MTREC complex
Description: A protein complex that consists of a heterodimer formed by Red1 and Mtl1 or homologs thereof, and that promotes degradation of mRNAs and noncoding RNAs and associates with different proteins to assemble heterochromatin via distinct mechanisms.
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GO Term
GO:1990629 | phospholamban complex
Description: A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels.
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GO Term
GO:0070545 | PeBoW complex
Description: A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
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GO Term
GO:0033596 | TSC1-TSC2 complex
Description: A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
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GO Term
GO:0016612 | molybdenum-iron nitrogenase complex
Description: An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer.
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GO Term
GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II
Description: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
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GO Term
GO:0017048 | Rho GTPase binding
Description: Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
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GO Term
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Description: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
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GO Term
GO:0031421 | invertasome
Description: A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.
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GO Term
GO:0032444 | activin responsive factor complex
Description: A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.
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GO Term
GO:0036391 | medial cortex septin ring
Description: A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins.
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GO Term
GO:0042731 | PH domain binding
Description: Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
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GO Term
GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
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GO Term
GO:0050789 | regulation of biological process
Description: Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
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GO Term
GO:0099572 | postsynaptic specialization
Description: A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
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GO Term
GO:0099091 | postsynaptic specialization, intracellular component
Description: A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
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GO Term
GO:0140090 | membrane curvature sensor activity
Description: Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.
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GO Term
GO:0062092 | Yae1-Lto1 complex
Description: A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p.
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GO Term
GO:0071254 | cytoplasmic U snRNP body
Description: A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies.
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GO Term
GO:0070131 | positive regulation of mitochondrial translation
Description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
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GO Term
GO:0070130 | negative regulation of mitochondrial translation
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
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GO Term
GO:0005869 | dynactin complex
Description: A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
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GO Term
GO:0001401 | SAM complex
Description: A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.
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GO Term
GO:0070419 | nonhomologous end joining complex
Description: A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.
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GO Term
GO:0031084 | BLOC-2 complex
Description: A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.
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GO Term
GO:1990341 | thrombospondin complex
Description: A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour.
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GO Term
GO:1990530 | Cdc50p-Drs2p complex
Description: A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome.
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GO Term
GO:0062091 | Ycf2/FtsHi complex
Description: A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma.
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GO Term
GO:0070975 | FHA domain binding
Description: Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.
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GO Term
GO:0031415 | NatA complex
Description: A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.
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GO Term
GO:0051191 | prosthetic group biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.
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GO Term
GO:0006045 | N-acetylglucosamine biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
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GO Term
GO:0006046 | N-acetylglucosamine catabolic process
Description: The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
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GO Term
GO:0007223 | Wnt signaling pathway, calcium modulating pathway
Description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
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GO Term
GO:0009368 | endopeptidase Clp complex
Description: A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.
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GO Term
GO:0009784 | transmembrane receptor histidine kinase activity
Description: Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
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GO Term
GO:0009885 | transmembrane histidine kinase cytokinin receptor activity
Description: Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
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GO Term
GO:0042496 | detection of diacyl bacterial lipopeptide
Description: The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.
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GO Term
GO:0048518 | positive regulation of biological process
Description: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
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GO Term
GO:0036002 | pre-mRNA binding
Description: Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
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GO Term
GO:0051190 | prosthetic group catabolic process
Description: The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.
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GO Term
GO:0071550 | death-inducing signaling complex assembly
Description: A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.
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GO Term
GO:0031145 | anaphase-promoting complex-dependent catabolic process
Description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
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GO Term
GO:0004938 | alpha2-adrenergic receptor activity
Description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.
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GO Term
GO:0004937 | alpha1-adrenergic receptor activity
Description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
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GO Term
GO:0004939 | beta-adrenergic receptor activity
Description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
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GO Term
GO:0110001 | toxin-antitoxin complex
Description: A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon.
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GO Term
GO:0000814 | ESCRT II complex
Description: An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
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GO Term
GO:0016613 | vanadium-iron nitrogenase complex
Description: An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer.
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GO Term
GO:0002430 | complement receptor mediated signaling pathway
Description: A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
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GO Term
GO:0002491 | antigen processing and presentation of endogenous peptide antigen via MHC class II
Description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
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GO Term
GO:0005011 | macrophage colony-stimulating factor receptor activity
Description: Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
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GO Term
GO:0016081 | synaptic vesicle docking
Description: The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
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GO Term
GO:0017090 | meprin A complex
Description: A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues.
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GO Term
GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II
Description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
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GO Term
GO:0033193 | Lsd1/2 complex
Description: A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.
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GO Term
GO:0043853 | methanol-CoM methyltransferase complex
Description: A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol.
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GO Term
GO:0048519 | negative regulation of biological process
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
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GO Term
GO:0002181 | cytoplasmic translation
Description: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
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GO Term
GO:0048199 | vesicle targeting, to, from or within Golgi
Description: The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.
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GO Term
GO:0005656 | nuclear pre-replicative complex
Description: A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
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GO Term
GO:0030134 | COPII-coated ER to Golgi transport vesicle
Description: A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
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GO Term
GO:0150057 | amylin receptor complex 2
Description: A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM).
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GO Term
GO:1990098 | core primosome complex
Description: A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication.
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GO Term
GO:0070621 | EGFR-Shc-Grb2-Sos complex
Description: A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
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GO Term
GO:0071203 | WASH complex
Description: A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.
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GO Term
GO:0048278 | vesicle docking
Description: The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
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GO Term
GO:0003923 | GPI-anchor transamidase activity
Description: Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.
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GO Term
GO:0043560 | insulin receptor substrate binding
Description: Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
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GO Term
GO:1990112 | RQC complex
Description: A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.
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GO Term
GO:0002483 | antigen processing and presentation of endogenous peptide antigen
Description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.
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GO Term
GO:0002478 | antigen processing and presentation of exogenous peptide antigen
Description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.
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GO Term
GO:0016240 | autophagosome membrane docking
Description: The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
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GO Term
GO:0035334 | Notch receptor processing, ligand-independent
Description: The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.
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GO Term
GO:0036105 | peroxisome membrane class-1 targeting sequence binding
Description: Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.
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GO Term
GO:0036106 | peroxisome membrane class-2 targeting sequence binding
Description: Interacting selectively and non-covalently with a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.
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GO Term
GO:0042567 | insulin-like growth factor ternary complex
Description: A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.
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GO Term
GO:0043769 | Tpg-containing telomere binding complex
Description: A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species.
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GO Term
GO:0097726 | LEM domain binding
Description: Interacting selectively and non-covalently with a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).
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GO Term
GO:0106054 | tRNA U34 thiol-transferase activity
Description: Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+.
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GO Term
GO:0120099 | procentriole replication complex
Description: A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates.
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GO Term
GO:0140366 | galectin lattice
Description: A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids.
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GO Term
GO:1990191 | cobalamin transport complex
Description: Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD.
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GO Term
GO:0061574 | ASAP complex
Description: A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
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GO Term
GO:0070086 | ubiquitin-dependent endocytosis
Description: Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.
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GO Term
GO:0070381 | endosome to plasma membrane transport vesicle
Description: A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis.
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GO Term
GO:0015572 | N-acetylglucosamine transmembrane transporter activity
Description: Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
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GO Term
GO:0016222 | procollagen-proline 4-dioxygenase complex
Description: A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.
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USDA
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