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Search results 5601 to 5700 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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0.024s

Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR024232
Name: Stage III sporulation protein AH-like
Type: Family
Description: Stage III sporulation protein AH (SpoIIIAH) is a protein that is involved in forespore engulfment. It forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling []. This family of proteins is found in bacteria, archaea and eukaryotes and so must have a wider function than in sporulation. Proteins in this family are typically between 174 and 223 amino acids in length.
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Protein Domain
IPR039193
Name: 28S ribosomal protein S17, mitochondrial
Type: Family
Description: This entry represents mitochondrial 28S ribosomal protein S17 from eukaryotes [ ]. The mammalian mitochondrial ribosome (mitoribosome), consists of small (28S) and large (39S) subunits, is responsible for the synthesis of 13 proteins of the inner mitochondrial membrane. The 28S small subunit, contains a 12S rRNA (950 nucleotides) and 29 proteins, is much more elongated than its bacterial 30S counterpart [].
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Protein Domain
IPR024234
Name: Protein of unknown function DUF3801
Type: Family
Description: This functionally uncharacterised protein family is found in bacteria. Proteins found in this family are typically between 158 and 187 amino acids in length and include the PcfB protein.
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Protein Domain
IPR024238
Name: Initiator binding protein 39kDa, C-terminal
Type: Domain
Description: Initiator binding protein 39kDa (IBP39) recognises the initiator (Inr), which in Trichomonas vaginalis is solely responsible for transcription start site selection. IBP39 consists of an N-terminal Inr binding domain, a flexible linker, and a C-terminal domain. The C-terminal domain interacts with the RNAP II large subunit C-terminal domain. Binding of IBP39 to Inr recruits RNAP II and initiates transcription [ ].This entry represents the C-terminal domain.
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Protein Domain
IPR036214
Name: Baseplate structural protein Gp11 superfamily
Type: Homologous_superfamily
Description: The bacteriophage baseplate controls host cell recognition, attachment, tail sheath contraction and viral DNA ejection. The baseplate is a multi-subunit assembly at the distal end of the tail, which is composed of long and short tail fibres [ ]. The tail region is responsible for attachment to the host bacteria during infection: long tail fibres enable host receptor recognition, while irreversible attachment is via short tail fibres. Recognition and attachment induce a conformational transition of the baseplate from a hexagonal to a star-shaped structure. In viruses such as Bacteriophage T4, Gp11 acts as a structural protein to connect the short tail fibres to the baseplate, while Gp9 connects the baseplate with the long tail fibres. Both Gp9 and Gp11 are trimers. Each Gp11 monomer consists of three domains, which are entwined together in the trimer: the N-terminal domains of the three monomers form a central, trimeric, parallel coiled coil surrounded by the entwined middle finger domains; the C-terminal domains appearto be responsible for trimerisation [ ].
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Protein Domain
IPR038877
Name: Thrombospondin type-1 domain-containing protein 1
Type: Family
Description: THSD1 may be involved in adhesion, including endothelial cell to extracellular matrix adhesion [ ].
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Protein Domain
IPR012245
Name: Molybdenum cofactor biosynthesis protein MoaB
Type: Family
Description: This entry represents the MoaB family of predicted molybdenum cofactor biosynthesis proteins and related sequences [ , ].
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Protein Domain
IPR034877
Name: Protein kinase C, PB1 domain
Type: Domain
Description: PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC), which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells [ , ]. The PB1 domain of Par6 forms a hetero-dimer with the PB1 domain of aPKC.PB1 domain is a modular domain mediating specific protein-protein interaction which play roles in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions []. The aPKC protein contains a type I/II PB1 domain.
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Protein Domain
IPR024221
Name: Beta-lactamase-inhibitor protein BLIP domain superfamily
Type: Homologous_superfamily
Description: The beta-lactamase-inhibitor protein (BLIP) is produced by Streptomyces species. BLIP acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP binds competitively to TEM-1 and makes direct contacts with TEM-1 active site residues. BLIP is able to inhibit a variety of class A beta-lactamases, possibly through flexibility of its two domains. The two tandemly repeated domains of BLIP have an alpha(2)-beta(4) structure, the β-hairpin loop from domain 1 inserting into the active site of beta-lactamase [ ]. BLIP shows no sequence similarity with BLIP-II, even though both bind to and inhibit TEM-1 [].This superfamily represents the structural domains of BLIP [ ].
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Protein Domain
IPR024220
Name: Protein of unknown function DUF3780
Type: Family
Description: This family of proteins have no known function. There are two conserved sequence motifs: PEERWWL and GWR. This family is found in a very sporadic set of bacterial species, suggesting that it may have been horizontally transferred. One protein ( ) is annotated as occurring on a plasmid.
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Protein Domain
IPR024229
Name: Protein of unknown function DUF3781
Type: Family
Description: This family of functionally uncharacterised proteins is found in bacteria and archaea. These proteins are typically between 82 and 98 amino acids in length and have two conserved sequence motifs: GKNWY and ITA.
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Protein Domain
IPR024227
Name: Protein of unknown function DUF3795
Type: Family
Description: This family of proteins is functionally uncharacterised and is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. These proteins are likely to be zinc binding given the conserved cysteines.
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Protein Domain
IPR038862
Name: Chloroplast thylakoid lumenal protein MPH2
Type: Family
Description: MPH2 (encoded by At4g02530) is a chloroplast thylakoid lumenal protein required for growth acclimation of plants under fluctuating light environments. A role in disassembling monomeric complexes for regeneration of dimeric functional PSII supercomplexes has been suggested for MPH2 [ ].
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Protein Domain
IPR038864
Name: Protein heading date repressor 1
Type: Family
Description: HDR1 regulates flowering time via a photoperiod-dependent pathway. It suppresses flowering under long-day conditions (LDs) by upregulating Hd1 and downregulating Ehd1. It is phosphorylated by OsK4, another suppressor of rice flowering under LDs [ ].
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Protein Domain
IPR024291
Name: Protein of unknown function DUF3829
Type: Family
Description: This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL/GvpF family of gas vesicle synthesis proteins ( ).
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Protein Domain
IPR024294
Name: Protein of unknown function DUF3810
Type: Family
Description: This family of bacterial proteins is functionally uncharacterised. Proteins in this family are typically between 333 and 377 amino acids in length and contain a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterised family of peptidase enzymes.
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Protein Domain
IPR024295
Name: Protein of unknown function DUF2705
Type: Family
Description: This bacterial family of proteins has no known function.
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Protein Domain
IPR024296
Name: Protein of unknown function DUF2710
Type: Family
Description: This family of uncharacterised proteins appears to be restricted to Mycobacteriaceae.
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Protein Domain
IPR024284
Name: Protein of unknown function DUF3826
Type: Family
Description: This is a putative sugar-binding family.
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Protein Domain
IPR024281
Name: Bacteriophage T7-like virion assembly protein
Type: Family
Description: This family of proteins represents the gene product 7.3 from T7 bacteriophage and T7-like phages. The protein is localised to the tail and is thought to be important in virion assembly. Particles assembled in the absence of the protein fail to adsorb to cells [ ].
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Protein Domain
IPR024271
Name: Protein of unknown function DUF3782
Type: Family
Description: This functionally uncharacterised family of proteins is found in bacteria and archaea. Proteins in this family are typically between 91 and 186 amino acids in length.
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Protein Domain
IPR024279
Name: Paramyxovirinae protein V, zinc-binding domain
Type: Domain
Description: The paramyxoviruses, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT [ ].The P mRNA encodes a variety of proteins beyond P. Protein V consists of PNT fused to a C-terminal zinc-binding region. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction [ ]. In the Henipavirus family, which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation [].
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Protein Domain
IPR024265
Name: Protein of unknown function DUF3788
Type: Family
Description: This family of functionally uncharacterised proteins is found in bacteria and archaea. Proteins in this family are typically between 137 and 149 amino acids in length and may be distantly related to RelE proteins.
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Protein Domain
IPR024269
Name: Protein of unknown function DUF3791
Type: Family
Description: This entry represents proteins of unknown function.
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Protein Domain
IPR034366
Name: Protein xmas, RNA recognition motif
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) found in Xmas, the Drosophila homologue of yeast Sac3p protein. Together with E(y)2, the Drosophila homologue of yeast Sus1p protein, Xmas is part of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex that is required in the regulation of mRNA transport and also involved in the efficient transcription regulation of the heat-shock protein 70 (hsp70) loci [ , , ]. This group of proteins are found in insects and contain an N-terminal RNA recognition motif (RRM), followed by a PCI domain.
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Protein Domain
IPR012656
Name: Conserved hypothetical protein CHP02421, QEGLA
Type: Family
Description: Members of this family include a possible metal-binding motif HEXXXH and, nearby, a perfectly conserved motif QEGLA. All members belong to the proteobacteria, including Agrobacterium tumefaciens and several species of Vibrio and Pseudomonas, and are found in only one copy per chromosome (Vibrio vulnificus, with two chromosomes, has two). The function is unknown.
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Protein Domain
IPR012546
Name: Protein of unknown function DUF1699
Type: Family
Description: This family contains many archaeal proteins which have very conserved sequences.
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Protein Domain
IPR012545
Name: Protein of unknown function DUF1697
Type: Family
Description: This family contains many hypothetical bacterial proteins.
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Protein Domain
IPR024533
Name: Protein of unknown function DUF3834
Type: Family
Description: This family is likely to be related to solute-binding lipo-proteins.
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Protein Domain
IPR024532
Name: Protein of unknown function DUF3830
Type: Family
Description: This is a family of bacterial and archaeal proteins. The structure of one of family members, , has been characterised and shown to contain a cyclophilin-like fold.
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Protein Domain
IPR024538
Name: Protein of unknown function DUF3878
Type: Family
Description: This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].
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Protein Domain
IPR024539
Name: Protein of unknown function DUF3877
Type: Family
Description: This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].
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Protein Domain
IPR012543
Name: Protein of unknown function DUF1694
Type: Family
Description: This family contains many hypothetical proteins.
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Protein Domain
IPR024522
Name: Protein of unknown function DUF3789
Type: Family
Description: This family of functionally uncharacterised bacterial proteins are approximately 40 amino acids in length. They contain two completely conserved residues (V and C) that may be functionally important.
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Protein Domain
IPR024523
Name: Protein of unknown function DUF3793
Type: Family
Description: This family of bacterial proteins is functionally uncharacterised. The proteins in this family contain two conserved sequence motifs: PHE and LGYP.
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Protein Domain
IPR024520
Name: Protein of unknown function DUF3558
Type: Family
Description: This family of bacterial proteins includes members annotated as putative lipoprotein lprB. However, their function is unknown.
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Protein Domain
IPR024526
Name: Protein of unknown function DUF3807
Type: Family
Description: This is a family of conserved fungal proteins of unknown function.
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Protein Domain
IPR024524
Name: Protein of unknown function DUF3800
Type: Family
Description: This family of proteins is functionally uncharacterised. Some family members possess a DE motif at their N terminus and a QXXD motif at their C terminus that may be functionally important.
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Protein Domain
IPR024525
Name: Protein of unknown function DUF3804
Type: Family
Description: Structural alignments indicate that this family of functionally uncharacterised proteins carry an NTF2-fold with a hydrophobic cavity. Family members also contain two highly conserved tryptophan residues toward their C-terminal ends.
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Protein Domain
IPR012551
Name: Protein of unknown function DUF1707
Type: Family
Description: This domain is found in a variety of actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.
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Protein Domain
IPR012550
Name: Protein of unknown function DUF1706
Type: Family
Description: This family contains many hypothetical proteins from bacteria and yeast. Proteins in this entry include Irc4 (increased recombination centres 4) from budding yeast [ ].
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Protein Domain
IPR012554
Name: Degradation enzyme regulation protein DegQ
Type: Family
Description: This family consists of the DegQ (formerly sacQ) regulatory peptides. The DegQ family of peptides control the rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis. DegQ is 46 amino acids long and activates the synthesis of degradative enzymes. The expression of this peptide was shown to be subjected both to catabolite repression and DegS-DegU-mediated control. Thus allowing an increase in the rate of synthesis of degQ under conditions of nitrogen starvation [ ]. DegQ also affects protease and levansucrose production [].
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Protein Domain
IPR024513
Name: Protein of unknown function DUF3334
Type: Family
Description: This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family are typically between 227 to 238 amino acids in length.
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Protein Domain
IPR024501
Name: Protein of unknown function DUF3141
Type: Family
Description: This family of proteins appears to be predominantly expressed in Proteobacteria. Their function is unknown.
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Protein Domain
IPR024505
Name: Protein of unknown function DUF3201
Type: Family
Description: This archaeal family of proteins has no known function.
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Protein Domain
IPR024502
Name: Protein of unknown function DUF3194
Type: Family
Description: Proteins in this family contain a novel alpha+beta fold, consisting of two α-helices (one N-terminal and one C-terminal) packed on the same side of a central β-hairpin [ ]. They share the structural similarity to Escherichia coli MinE, a protein which controls that division occurs at the midcell site []. A hypothetical protein from Methanobacterium thermoautotrophicum (Mth), Mth677, is included in this entry.
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Protein Domain
IPR024503
Name: Protein of unknown function DUF3196
Type: Family
Description: The entry comprises bacterial proteins of unknown function. One of the proteins in this entry, MPN330, is thought to involved in a cellular function that has yet to be characterised. The protein has 11 helices and a novel fold. No function is currently known for this protein.
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Protein Domain
IPR024508
Name: Protein of unknown function DUF3226
Type: Family
Description: This entry represents a family of functionally uncharacterised prokaryotic proteins.
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Protein Domain
IPR024506
Name: Protein of unknown function DUF3217
Type: Family
Description: This family of proteins with unknown function appears to be restricted to Mycoplasma and Ruminococcus spp. The structure of Uncharacterized protein MG376 homologue from Mycoplasma pneumoniae shows an OB fold with six β-strands and three loops forming a β-barrel that is capped by one α-helix [ ]. Its specific function is still unknown.
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Protein Domain
IPR024569
Name: Lactate utilization protein B, C-terminal
Type: Domain
Description: This entry represents the C-terminal domain of Lactate utilization protein B, a family of 4Fe-4S, iron-sulphur cluster binding proteins. These proteins have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulphur clusters.
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Protein Domain
IPR042553
Name: TSC22 domain family protein 4
Type: Family
Description: TSC22 domain family protein 4 (TSC22D4) is a transcription factor that regulates hepatic lipid metabolism during cancer cachexia and acts as a checkpoint in systemic glucose metabolism in both mice and human [, ].
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Protein Domain
IPR024556
Name: Protein of unknown function DUF3599
Type: Family
Description: This family of bacterial proteins includes phage-like element PBSX protein xkdH from Bacillus subtilis. The function of the family is unknown.
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Protein Domain
IPR024559
Name: Protein of unknown function DUF3846
Type: Family
Description: A family of uncharacterised proteins found by clustering human gut metagenomic sequences [ ]. In a few cases it is found fused to the C terminus of ArdA (Pfam:PF07275). ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification [].
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Protein Domain
IPR024540
Name: Protein of unknown function DUF3879
Type: Family
Description: This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].
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Protein Domain
IPR024541
Name: Protein of unknown function DUF3881
Type: Family
Description: This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].
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Protein Domain
IPR045077
Name: Ribosomal protein L3, archaeal/eukaryotic type
Type: Family
Description: Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [ , ].This entry represents archaeal and eukaryotic L3 proteins.
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Protein Domain
IPR022403
Name: Alcohol ABC transporter, permease protein
Type: Family
Description: Members of this protein family, part of a larger class of efflux-type ABC transport permease proteins, are found exclusively in genomic contexts with pyrroloquinoline-quinone (PQQ) biosynthesis enzymes and/or PQQ-dependent alcohol dehydrogenases, such as the phenylethanol dehydrogenase PedE of Pseudomonas putida U. Members include PedC, an apparent phenylethanol transport protein whose suggested role is efflux to limit intracellular concentrations of toxic metabolites during phenylethanol catalysis.
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Protein Domain
IPR012427
Name: Protein of unknown function DUF1622
Type: Family
Description: This is a family of highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.
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Protein Domain
IPR012426
Name: Cell division protein SepF, archaea
Type: Family
Description: This protein family represents the Cell division protein SepF and similar uncharacterised archaeal protein. Proteins in this family show sequence similarity to the bacterial SepF protein, which accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation [ ]. SepF from the halofilic archaea Haloferax volcanii co-localizes with the homologues FtsZ1 and FtsZ2 and is essential for cell division [].
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Protein Domain
IPR024416
Name: Protein of unknown function DUF2738
Type: Family
Description: This is a family of plant and viral proteins whose function is unknown.
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Protein Domain
IPR024418
Name: Protein of unknown function DUF3862
Type: Family
Description: Proteins in this family show structural similarity to beta-lactamase inhibitory proteins.
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Protein Domain
IPR024419
Name: Protein of unknown function YvrJ
Type: Family
Description: This entry is represents a family of uncharacterised protein. The function of the Bacillus subtilis YvrJ protein is not known, but its expression is regulated by the cell envelope stress-inducible sigma factor YvrI [ ].
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Protein Domain
IPR012436
Name: Protein of unknown function DUF1633
Type: Family
Description: This family contains sequences derived from a group of hypothetical proteins expressed by Arabidopsis thaliana (Mouse-ear cress). These sequences are highly similar and the region concerned is about 100 residues long.
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Protein Domain
IPR024400
Name: Protein of unknown function DUF2635
Type: Family
Description: This family consists of uncharacterised proteins found in bacteria and bacteriophages. It includes protein Gp38 from Enterobacteria phage Mu.
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Protein Domain
IPR024409
Name: Protein of unknown function DUF3833
Type: Family
Description: This is a family of uncharacterised proteins found in Proteobacteria.
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Protein Domain
IPR012434
Name: Protein of unknown function DUF1631
Type: Family
Description: The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.
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Protein Domain
IPR012433
Name: Protein of unknown function DUF1629
Type: Family
Description: This family consists of sequences from hypothetical proteins thought to be expressed by two members of the Xanthomonas genus. The region in question is 125 amino acid residues long.
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Protein Domain
IPR012432
Name: Protein of unknown function DUF1627
Type: Family
Description: This is a group of hypothetical proteins predicted to be expressed in a number of bacterial species.
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Protein Domain
IPR036437
Name: Outer surface protein C-like superfamily
Type: Homologous_superfamily
Description: Members of this superfamily are lipoproteins that are probably involved in evasion of the host immune system by pathogens [ ]. Borrelia burgdorferi, the causative agent of Lyme disease, has the potential of producing more than 100 different lipoproteins that could become anchored to the outer membrane [ ]. One of these is outer surface protein C (OspC). OspC is a largely α-helical protein that forms a dimer with a characteristic central four-helical bundle formed by association of the two longest helices from each subunit [, ].
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Protein Domain
IPR012469
Name: Protein of unknown function DUF1688
Type: Family
Description: This family of uncharacterised fungal and bacterial proteins includes URC4 from the yeast Saccharomyces kluyveri. URC4 is a protein involved in uracil catabolism, but its exact function is not known [ , ].
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Protein Domain
IPR012468
Name: Protein of unknown function DUF1686
Type: Family
Description: The members of this family are all hypothetical proteins of unknown function expressed by the eukaryotic parasite Encephalitozoon cuniculi GB-M1. The region in question is approximately 250 amino acids long.
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Protein Domain
IPR024452
Name: Protein of unknown function DUF3876
Type: Family
Description: This bacterial family of conserved proteins has no known function.
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Protein Domain
IPR012460
Name: Protein of unknown function DUF1667
Type: Family
Description: Hypothetical archaeal and bacterial proteins make up this family. A few proteins are annotated as being potential metal-binding proteins, and in fact the members of this family have four highly conserved cysteine residues, but no further literature evidence was found in this regard.
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Protein Domain
IPR012467
Name: Protein of unknown function DUF1684
Type: Family
Description: The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long.
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Protein Domain
IPR012465
Name: Protein of unknown function DUF1678
Type: Family
Description: This family is composed of uncharacterised proteins expressed by Methanopyrus kandleri, a hyperthermophilic archaeon.
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Protein Domain
IPR012464
Name: Protein of unknown function DUF1676
Type: Family
Description: This family contains proteins of unknown function expressed by Drosophila melanogaster and Anopheles gambiae.
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Protein Domain
IPR024444
Name: Protein of unknown function DUF2706
Type: Family
Description: This family of proteins with unknown function appears to be restricted to Rickettsia spp.
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Protein Domain
IPR012471
Name: Protein of unknown function DUF1690
Type: Family
Description: Family of uncharacterised fungal proteins.
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Protein Domain
IPR012448
Name: Protein of unknown function DUF1652
Type: Family
Description: The proteins in this entry have not been characterised.
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Protein Domain
IPR012447
Name: Protein of unknown function DUF1651
Type: Family
Description: The proteins in this entry have not been characterised.
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Protein Domain
IPR012446
Name: Calcium release-activated calcium channel protein
Type: Family
Description: This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [ ].
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Protein Domain
IPR012440
Name: Protein of unknown function DUF1641
Type: Family
Description: Archaeal and bacterial hypothetical proteins are found in this family, with the region in question being approximately 40 residues long.
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Protein Domain
IPR012444
Name: Protein of unknown function DUF1647
Type: Family
Description: This entry consists of hypothetical proteins of unknown function.
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Protein Domain
IPR012443
Name: Protein of unknown function DUF1646
Type: Family
Description: Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaeon Methanosarcina mazei (Methanosarcina frisia) ( , and ).
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Protein Domain
IPR000475
Name: Retroviral Vif (Viral infectivity) protein
Type: Family
Description: The virion infectivity factor (vif) is an accessory protein, which is essential for HIV replication in host cells. Vif of Human immunodeficiency virus 1 (HIV-1) affects the infectivity of virus particles [ ] to T lymphocytes and macrophages (in some casesincreasing the infectivity of HIV-1 particles by 100- to 1000-fold), but has no direct effect on transcription, translation or virus release. Vif antibodies are found in the sera of patients at all levels of HIV-1 infection, indicating that vif is expressed in natural infections in vivo. Other lentiviruses, including Simian immunodeficiency virus (SIV-cpz), Visna/Maedi virus, and Feline immunodeficiency virus (FIV), have vif open reading frames, suggesting vif plays an essential role during natural infections [].The expression of vif in BHK-21 cells has been shown to be linked to a modification of the C terminus of gp41env, which modification is inhibited by trans-epoxysuccinyl-L-leucylamido-(4-guanidio)butane (E64), a specific inhibitor of cysteine proteases []. Coupled with sequence analysis and the effects of point mutations in vif, it has been suggested that vif could be a cysteine protease. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid [ ].In humans, HIV-1 Vif hijacks cellular E3 ligase components containing CUL5, RBX2, ELOB, ELOC and CBFbeta, to poly-ubiquitinate antiviral cellular factors, APOBEC3 proteins [ , , ]. In sheep and goats, Caprine arthritis encephalitis virus (CAEV) Vif is responsible for degradation of oaA3Z2-Z3 [].
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Protein Domain
IPR024423
Name: Protein of unknown function DUF3050
Type: Family
Description: This family of proteins has no known function.
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Protein Domain
IPR024422
Name: Protein of unknown function, OB-fold-containing
Type: Family
Description: The function of the proteins in this entry is not known, but they contain a novel variant of the nucleic acid-binding OB fold [].
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Protein Domain
IPR024426
Name: Protein of unknown function DUF2694
Type: Family
Description: This family of proteins with unknown function appears to be restricted to Mycobacterium spp.
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Protein Domain
IPR012452
Name: Protein of unknown function DUF1657
Type: Family
Description: This domain appears to be restricted to the Bacillales.
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Protein Domain
IPR012451
Name: Protein of unknown function DUF1656
Type: Family
Description: The proteins in this entry have no known function and belong to the AaeX family.
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Protein Domain
IPR012456
Name: Protein of unknown function DUF1661
Type: Family
Description: The proteins in this entry have not been characterised.
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Protein Domain
IPR012455
Name: Protein of unknown function DUF1660
Type: Family
Description: This protein family of unknown function is found in several bacteriophages and suspected prophages.
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Protein Domain
IPR012454
Name: Protein of unknown function DUF1659
Type: Family
Description: This family consists of hypothetical bacterial proteins of unknown function
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Protein Domain
IPR024492
Name: Protein of unknown function DUF2764
Type: Family
Description: This bacterial family of proteins has no known function.
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Protein Domain
IPR024490
Name: Protein of unknown function DUF2759
Type: Family
Description: This family of proteins with unknown function appear to be restricted to Bacillales.
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Protein Domain
IPR024497
Name: Protein of unknown function DUF2773
Type: Family
Description: This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.
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Protein Domain
IPR024494
Name: Protein of unknown function DUF2770
Type: Family
Description: Members in this family of proteins from Enterobacteria are annotated as YceO; however, currently no function is known.
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Protein Domain
IPR024495
Name: Protein of unknown function DUF2771
Type: Family
Description: This bacterial family of proteins has no known function.
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Protein Domain
IPR024485
Name: Protein of unknown function DUF2680
Type: Family
Description: Members in this family of proteins are annotated as YckD however currently no function is known.
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Protein Domain
IPR024486
Name: Protein of unknown function DUF2617
Type: Family
Description: This is a family of proteins with unknown function.
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The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
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