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Search results 5701 to 5800 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR024483
Name: Protein of unknown function DUF2700
Type: Family
Description: This is a family of proteins with unknown function.
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Protein Domain
IPR024484
Name: Protein of unknown function DUF2709
Type: Family
Description: Members of this family appear restricted to Chlamydiales. Their function is unknown.
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Protein Domain
IPR024488
Name: Protein of unknown function DUF2777
Type: Family
Description: This family of proteins with unknown function appears to be restricted to Bacillaceae.
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Protein Domain
IPR024470
Name: Protein of unknown function DUF2545
Type: Family
Description: This family of proteins with unknown function appear to be restricted to Enterobacteriaceae. Their sequences are highly conserved.
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Protein Domain
IPR024471
Name: Protein of unknown function DUF2715
Type: Family
Description: This family of proteins with unknown function appears to be largely found in spirochaete bacteria. They are related to membrane beta barrel proteins.
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Protein Domain
IPR024479
Name: Protein of unknown function DUF3866
Type: Family
Description: This family of proteins is currently functionally uncharacterised.
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Protein Domain
IPR024476
Name: Protein of unknown function DUF3861
Type: Family
Description: This entry represents a family of proteins of unknown function which are found predominantly in the proteobacteria. The structurally characterised member of this family ( ) adopts a novel fold consisting of a long N-terminal β-hairpin followed by three alpha helices. This structure shows some resemblance to three-helical bundle folds such as the serum albumin-like fold.
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Protein Domain
IPR024464
Name: Protein of unknown function DUF2391
Type: Family
Description: Members of this protein family are found in archaea and bacteria. Their function is unknown.
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Protein Domain
IPR024469
Name: Protein of unknown function DUF2538
Type: Family
Description: This family of proteins has no known function.
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Protein Domain
IPR036499
Name: Non-structural protein NSP9 superfamily, coronavirus
Type: Homologous_superfamily
Description: NSP9 is a single-stranded RNA-binding viral protein involved in RNA synthesis, essential for the coronavirus replication [ , , ]. The dimerisation of NSP9 is essential for binding and orienting RNA for subsequent use by the replicase machinery. NSP9 is composed of seven antiparallel β-strands and a single α-helix hat are arranged into a single compact domain and form a cone-shaped β-barrel flanked by the C-terminal α-helix () [ , ]. The NSP9 dimer interface is formed by the N-finger motifs and the parallel association of the C-terminal α-helices GXXXG motifs. The N- and C-terminal regions are more conserved than the central core one, and the GXXXG motif is strictly conserved [, ]. NSP9 binds to discrete regions on the 7SL RNA component of the signal recognition particle (SRP) and interfere with protein trafficking to the cell membrane upon infection, which interferes with essential host functions, and suppresses host immune defenses [].
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Protein Domain
IPR035014
Name: cGMP-dependent protein kinase, catalytic domain
Type: Domain
Description: Mammals have two cGMP-dependent protein kinase (cGK) isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic centre by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase [ , ].cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm [ , , ].
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Protein Domain
IPR045067
Name: Wee1-like protein kinase, catalytic domain
Type: Domain
Description: PKs catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This entry includes Wee1 from Arabidopsis. Wee1 is a cell cycle checkpoint kinase that is involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis [ , ]. It has been shown that Arabidopsis Wee1 directly interacts with and phosphorylates the E3 ubiquitin ligase FBL17 that promotes the degradation of CDK inhibitors [].
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Protein Domain
IPR009109
Name: Ran-GTPase activating protein 1, C-terminal
Type: Domain
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores [ ]. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Protein Domain
IPR021637
Name: Protein of unknown function DUF3243
Type: Family
Description: This family of proteins with unknown function includes uncharacterised proteins ymfJ and yflH. The family appears to be restricted to Firmicutes.
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Protein Domain
IPR022115
Name: Protein of unknown function DUF3654
Type: Family
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 193 and 612 amino acids in length.
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Protein Domain
IPR022106
Name: Paired box protein 7, C-terminal
Type: Domain
Description: This domain is found in the C-terminal region of Pax7, which is a transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation [ ]. Proteins containing this domain also include Pax3.
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Protein Domain
IPR022109
Name: Protein of unknown function DUF3649
Type: Family
Description: This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length.
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Protein Domain
IPR022108
Name: Protein of unknown function DUF3648
Type: Family
Description: This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 53 and 3115 amino acids in length. There are two completely conserved residues (A and F) that may be functionally important.
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Protein Domain
IPR024758
Name: Inheritance of peroxisomes protein 1
Type: Family
Description: Inp1 is a peroxisomal membrane protein that binds Pex25p, Pex30p, and Vps1p, all of which are involved in controlling peroxisome division. The levels of Inp1p vary with the cell cycle, and Inp1 acts as a factor that retains peroxisomes in cells and controls peroxisome division [ ]. Inp1p promotes the retention of peroxisomes in mother cells and buds of budding yeast by attaching peroxisomes to as-yet-unidentified cortical structures [].
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Protein Domain
IPR036731
Name: Baculovirus telokin-like protein 20 superfamily
Type: Homologous_superfamily
Description: The baculovirus, Autographa californica nuclear polyhedrosis virus (AcMNPV), telokin-like protein (Tlp20) lies in a region of the baculoviral genome that is expressed late in the viral replication cycle, however its function is unknown. Tlp20 was discovered using anti-telokin antibodies, telokin being the C-terminal domain of smooth-muscle myosin light-chain kinase []. Both Tlp20 and telokin display a seven-stranded antiparallel β-barrel structure, although the 3-dimensional structures of the β-barrels are different and there is no sequence homology between the two. Tlp20 is structurally similar to dUTPase in its fold and trimeric assembly [].
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Protein Domain
IPR036728
Name: Pheromone/general odorant binding protein superfamily
Type: Homologous_superfamily
Description: The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors [ ]. This superfamily is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).Members of this superfamily has an EF Hand-like fold, which has a core of four helices and an array of two opened hairpins. The N-terminal extension of these domains, containing a few short helices, forms a flexible lid for the binding cavity.
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Protein Domain
IPR047041
Name: GTP-binding protein BipA, GTP-binding domain
Type: Domain
Description: This entry includes the GTP-binding protein BipA or TypA (Tyrosine phosphorylated protein A (TypA), also known as 50S ribosomal subunit assembly factor BipA) from bacteria and its homologue from Arabidopsis (putative elongation factor TypA-like SVR3). BipA is a 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures. It also functions as a translation factor that is required specifically for the expression of the transcriptional modulator Fis. BipA binds the 70S ribosome at a site that coincides with that of EF-G and has a GTPase activity that is sensitive to high GDP:GTP ratios and is stimulated by 70S ribosomes programmed with mRNA and aminoacylated tRNAs [ , , ]. The growth rate-dependent induction of BipA allows the efficient expression of Fis, thereby modulating a range of downstream processes, including DNA metabolism and type III secretion. This GTPase impacts interactions between enteropathogenic E.coli (EPEC) and epithelial cells and also has an effect on motility []. It appears to be involved in the regulation of several processes important for infection, including rearrangements of the cytoskeleton of the host, bacterial resistance to host defense peptides, flagellum-mediated cell motility, and expression of K5 capsular genes [, ].TypA-like SVR3 is a putative chloroplastic elongation factor involved in response to chilling stress. It is required for proper chloroplast rRNA processing and/or translation at low temperature [ ] and it is also involved in plastid protein homeostasis [].This entry represents the GTP-binding domain.
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Protein Domain
IPR022152
Name: Protein of unknown function DUF3682
Type: Family
Description: This domain family is found in eukaryotes, and is typically between 125 and 136 amino acids in length.
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Protein Domain
IPR022153
Name: Protein of unknown function DUF3683
Type: Family
Description: This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with , , .
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Protein Domain
IPR022155
Name: Protein of unknown function DUF3684
Type: Family
Description: This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.
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Protein Domain
IPR046119
Name: Protein of unknown function DUF6116
Type: Family
Description: This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found mainly in Proteobacteria.
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Protein Domain
IPR046118
Name: Protein of unknown function DUF6115
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 288 amino acids in length.
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Protein Domain
IPR046117
Name: Protein of unknown function DUF6054
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this group are found primarily in Firmicute bacteria.
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Protein Domain
IPR046116
Name: Protein of unknown function DUF6053
Type: Family
Description: This entry describes proteins of unknown function.
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Protein Domain
IPR046115
Name: Protein of unknown function DUF6052
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001397) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from the lidamycin biosynthetic gene cluster from Streptomyces globisporus C-1027 and appears to be predominantly present in bacteria [ ].
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Protein Domain
IPR046114
Name: Protein of unknown function DUF6051
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroidetes bacteria. Proteins in this family are typically between 377 and 403 amino acids in length.
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Protein Domain
IPR046113
Name: Protein of unknown function DUF6050
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mainly in Clostridia.
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Protein Domain
IPR009181
Name: Uncharacterised conserved protein UCP004929, methanogenesis
Type: Family
Description: The exact function of this protein is unknown, but likely is linked to methanogenesis or a process closely connected to it.
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Protein Domain
IPR046112
Name: Protein of unknown function DUF6049
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found primarily in Actinobacteria. Proteins in this family are typically between 695 and 823 amino acids in length.
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Protein Domain
IPR046111
Name: Protein of unknown function DUF6048
Type: Family
Description: This entry represents a family of uncharacterised membrane spanning beta barrel proteins. This family of proteins is primarily found in Bacteroidetes bacteria.
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Protein Domain
IPR046110
Name: Protein of unknown function DUF6047
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Bacteroidetes bacteria.
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Protein Domain
IPR022142
Name: Protein of unknown function DUF3673
Type: Family
Description: This domain family is found in eukaryotes, and is approximately 50 amino acids in length.
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Protein Domain
IPR046108
Name: Protein of unknown function DUF6045
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found primarily in Firmicute bacteria.
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Protein Domain
IPR046107
Name: Protein of unknown function DUF6044
Type: Family
Description: This family of integral membrane proteins is functionally uncharacterised. This family of proteins is mainly found in bacteria. There is a conserved YNG sequence motif.
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Protein Domain
IPR022146
Name: Protein of unknown function DUF3678
Type: Family
Description: This domain family is found in eukaryotes, and is approximately 40 amino acids in length.
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Protein Domain
IPR046106
Name: Protein of unknown function DUF6043
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroidetes.
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Protein Domain
IPR022149
Name: Protein of unknown function DUF3681
Type: Family
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 212 amino acids in length. There is a single completely conserved residue G that may be functionally important.
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Protein Domain
IPR046105
Name: Protein of unknown function DUF6042
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000291) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the A54145 biosynthetic gene cluster from Streptomyces fradiae [ ].
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Protein Domain
IPR046104
Name: Protein of unknown function DUF6041
Type: Family
Description: This entry represents a member of a bacterial biosynthetic gene cluster (BGC). This BGC (BGC0000260) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the prodigiosin biosynthetic gene cluster from Hahella chejuensis KCTC 2396 [ ].
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Protein Domain
IPR009190
Name: Protein of unknown function DUF1462
Type: Family
Description: There are currently no experimental data for members of this group of bacterial proteins or their homologues. A crystal structure of revealed a thioredoxin-like fold, its core consisting of three layers alpha/beta/alpha.
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Protein Domain
IPR046103
Name: Protein of unknown function DUF6040
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins of this family are mainly found in Clostridia.
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Protein Domain
IPR046102
Name: Protein of unknown function DUF6039
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001101) is described by MIBiG as an example of the following biosynthetic classes, NRP and Polyketide (Macrolide). This family includes a protein from the leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus and appears to be predominantly found in Actinobacteria [ ].
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Protein Domain
IPR046101
Name: Protein of unknown function DUF6038
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000758) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the capsular polysaccharide biosynthetic gene cluster from Staphylococcus aureus [ ].
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Protein Domain
IPR030983
Name: Bacterial microcompartment shell protein EutL
Type: Family
Description: A bacterial microcompartment is a protein-based metabolic organelle where several enzymes and metabolites are brought together. EutL is one of the shell proteins that form the ethanolamine utilization (Eut) microcompartment. Its structure has been revealed [ ].
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Protein Domain
IPR030984
Name: Bacterial microcompartment shell protein PduB
Type: Family
Description: A bacterial microcompartment is a protein-based metabolic organelle where several enzymes and metabolites are brought together. PduB is one of the shell proteins that form the propanediol-utilization (Pdu) microcompartment. The structure of PudB has been solved [ ].
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Protein Domain
IPR046100
Name: Protein of unknown function DUF6037
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000758) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the capsular polysaccharide biosynthetic gene cluster from Staphylococcus aureus [ ].
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Protein Domain
IPR022134
Name: Protein of unknown function DUF3667
Type: Family
Description: This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. There is a single completely conserved residue P that may be functionally important.
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Protein Domain
IPR022139
Name: Protein of unknown function DUF3671
Type: Family
Description: This domain family is found in eukaryotes, and is typically between 96 and 116 amino acids in length.
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Protein Domain
IPR005972
Name: Nitrogenase molybdenum-iron protein alpha chain
Type: Family
Description: The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two components, component I (also called dinitrogenase, or Fe-Mo protein), an alpha2beta2 tetramer encoded by the nifD and nifK genes, and component II (dinitrogenase reductase, or Fe protein) a homodimer encoded by the nifH gene [ , ] which has an Fe4S4 cluster bound between the subunits and two ATP-binding domains. The Fe protein supplies energy by ATP hydrolysis, and transfers electrons from reduced ferredoxin or flavodoxin to component 1 for the reduction of molecular nitrogen to ammonia [ , ]. Nitrogenase contains two unusual rare metal clusters; one of them is the iron molybdenum cofactor (FeMo-co), which is considered to be the site of dinitrogen reduction and whose biosynthesis requires the products of the nifNE operon and of some other nif genes []. It has been proposed that nifNE might serve as a scaffold upon which FeMo-co is built and then inserted into component I [].This entry refers to the alpha subunit of the MoFe protein (component I) of molybdenum (Mo-) nitrogenase, which is encoded by the nifD gene.
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Protein Domain
IPR034109
Name: Sm-like protein Lsm11, middle domain
Type: Domain
Description: This entry represents the middle domain of Lsm11.The eukaryotic Sm and Sm-like (Lsm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel β-sheet [ , , ]. Lsm11 is an SmD2-like subunit which binds U7 snRNA along with Lsm10 and five other Sm subunits to form a 7-membered ring structure. Lsm11 and the U7 snRNP of which it is a part are thought to play an important role in histone mRNA 3' processing [ , ].
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Protein Domain
IPR022123
Name: Protein of unknown function DUF3658
Type: Family
Description: This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with . There are two completely conserved residues (D and R) that may be functionally important.
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Protein Domain
IPR022124
Name: Protein of unknown function DUF3659
Type: Family
Description: This domain family is found in bacteria and eukaryotes, and is approximately 70 amino acids in length.
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Protein Domain
IPR010157
Name: CRISPR type I-A/APERN-associated protein Csa5
Type: Family
Description: This entry represents a minor family of Cas protein found in the (all archaeal) APERN subtype of CRISPR/Cas locus, so the family is designated Csa5, for CRISPR/Cas Subtype Protein 5 [ ] .The CRISPR-Cas system is a prokaryotic defense mechanism against foreign genetic elements. The key elements of this defense system are the Cas proteins and the CRISPR RNA. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) are a family of DNA direct repeats separated by regularly sized non-repetitive spacer sequences that are found in most bacterial and archaeal genomes [ ]. CRISPRs appear to provide acquired resistance against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).The defense reaction is divided into three stages. In the adaptation stage, the invader DNA is cleaved, and a piece of it is selected to be integrated as a new spacer into the CRISPR locus, where it is stored as an identity tag for future attacks by this invader. During the second stage (the expression stage), the CRISPR RNA (pre-crRNA) is transcribed and subsequently processed into the mature crRNAs. In the third stage (the interference stage), Cas proteins, together with crRNAs, identify and degrade the invader [ , , ].The CRISPR-Cas systems have been sorted into three major classes. In CRISPR-Cas types I and III, the mature crRNA is generally generated by a member of the Cas6 protein family. Whereas in system III the Cas6 protein acts alone, in some class I systems it is part of a complex of Cas proteins known as Cascade (CRISPR-associated complex for antiviral defense). The Cas6 protein is an endoribonuclease necessary for crRNA production whereas the additional Cas proteins that form the Cascade complex are needed for crRNA stability [ ].
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Protein Domain
IPR036766
Name: Fe(II) trafficking protein YggX superfamily
Type: Homologous_superfamily
Description: The protein superfamily represented by this entry, YggX, serves to protect Fe-S clusters from oxidative damage [ ]. The effect is two-fold: proteins that rely on Fe-S clusters do not become inactivated, and the release of free iron and hydrogen peroxide--a DNA damaging agent--is prevented. These observations are consistent with the hypothesis that YggX chelates free iron, and recent experiments show that YggX can indeed bind Fe(II) in vitro and in vivo []. Furthermore, YggX has a positive effect on the action of at least one Fe(II)-responsive protein. The combined actions of YggX is reminiscent of iron trafficking proteins [], and YggX is therefore proposed to play a role in Fe(II) trafficking []. In Escherichia coli, YggX was shown to be under the transcriptional control of the redox-sensing SoxRS system [].Structurally, YggX has a beta(2)-alpha(3) fold and contains a zinc-less 'zinc finger'-like fold.
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Protein Domain
IPR022190
Name: Protein of unknown function DUF3716
Type: Family
Description: This domain family is found in eukaryotes, and is approximately 60 amino acids in length.
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Protein Domain
IPR022191
Name: Protein of unknown function DUF3717
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 117 amino acids in length. There is a conserved AIN sequence motif. There are two completely conserved residues (L and Y) that may be functionally important.
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Protein Domain
IPR022194
Name: Protein of unknown function DUF3719
Type: Domain
Description: This domain is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important. This domain is present in proteins such as primary cilium assembly protein FAM149B1.
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Protein Domain
IPR022193
Name: Protein of unknown function DUF3718
Type: Family
Description: This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important.
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Protein Domain
IPR022196
Name: Protein of unknown function DUF3721
Type: Family
Description: This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. There is a conserved WMPC sequence motif. There are two completely conserved residues (A and C) that may be functionally important.
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Protein Domain
IPR022195
Name: Protein of unknown function DUF3720
Type: Family
Description: This entry represents a family of uncharacterised proteins found in Trypanosoma.
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Protein Domain
IPR022198
Name: Protein of unknown function DUF3723
Type: Family
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.
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Protein Domain
IPR022199
Name: Protein of unknown function DUF3725
Type: Family
Description: This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with . There is a conserved FLE sequence motif.
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Protein Domain
IPR046158
Name: Protein of unknown function DUF6160
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mainly in Gammaproteobacteria.
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Protein Domain
IPR046157
Name: Protein of unknown function DUF6159
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea.
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Protein Domain
IPR046156
Name: Protein of unknown function DUF6158
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus and appears to be predominantly found in Actinobacteria [ ].
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Protein Domain
IPR046155
Name: Protein of unknown function DUF6157
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found primarly in bacteria.
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Protein Domain
IPR046154
Name: Protein of unknown function DUF6156
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mainly in Proteobacteria. There are two conserved sequence motifs: RNT and VYGE.
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Protein Domain
IPR046153
Name: Protein of unknown function DUF6155
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and some species of archaea.
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Protein Domain
IPR046152
Name: Protein of unknown function DUF6154
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mainly in Firmicutes.
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Protein Domain
IPR046151
Name: Protein of unknown function DUF6153
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001435) is described by MIBiG as an example of the following biosynthetic classes, polyketide and NRP (non-ribosomal peptide). It includes a member from the ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306 and appears to be predominantly found in Actinobacteria [ , ].
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Protein Domain
IPR046150
Name: Protein of unknown function DUF6152
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mostly in Proteobacteria and Acidobacteria. There are two conserved sequence motifs: AHH and NPH.
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Protein Domain
IPR022181
Name: Bcl2-/adenovirus E1B 19kDa-interacting protein 2
Type: Family
Description: This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.
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Protein Domain
IPR022183
Name: Protein of unknown function DUF3710
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 284 amino acids in length. There are two conserved sequence motifs: DLG and DGPRW.
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Protein Domain
IPR022185
Name: Protein of unknown function DUF3712
Type: Family
Description: This domain family is found in Fungi, and is approximately 130 amino acids in length. This domain has a distant similarity to LEA-2 domain [ ].
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Protein Domain
IPR022186
Name: Protein of unknown function DUF3713
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 92 and 1225 amino acids in length. There is a single completely conserved residue S that may be functionally important.
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Protein Domain
IPR046149
Name: Protein of unknown function DUF6151
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and some species of eukaryotes.
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Protein Domain
IPR046148
Name: Protein of unknown function DUF6150
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Bacteroidetes and Proteobacteria.
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Protein Domain
IPR046147
Name: Protein of unknown function DUF6149
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mainly in archaea.
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Protein Domain
IPR046146
Name: Protein of unknown function DUF6148
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found mainly in bacteria.
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Protein Domain
IPR046145
Name: Protein of unknown function DUF6147
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is primarly found in Firmicutes.
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Protein Domain
IPR046144
Name: Protein of unknown function DUF6146
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria.
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Protein Domain
IPR046143
Name: Protein of unknown function DUF6145
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found predominantly in Firmicutes.
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Protein Domain
IPR046142
Name: Protein of unknown function DUF6144
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and some species of archaea.
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Protein Domain
IPR046141
Name: Protein of unknown function DUF6143
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found predominantly in Firmicutes.
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Protein Domain
IPR046140
Name: Protein of unknown function DUF6142
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Firmicutes.
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Protein Domain
IPR022172
Name: Protein of unknown function DUF3703
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length.
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Protein Domain
IPR009197
Name: Microcystin LR degradation protein MlrC
Type: Family
Description: Proteins in this entry are involved in degradation of the cyanobacterial heptapeptide hepatotoxin microcystin LR, and are encoded in the mlr gene cluster [ ]. MlrC from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) is believed to mediate the last step of peptidolytic degradation of the tetrapeptide. It is suspected to be a metallopeptidase based on homology to known peptidases and its inhibition by metal chelators. The proteins encoded by the mlr cluster may be involved in cell wall peptidoglycan cycling and subsequently act fortuitously in hydrolysis of microcystin LR.
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Protein Domain
IPR022173
Name: Protein of unknown function DUF3704
Type: Family
Description: This domain family is found in eukaryotes, and is approximately 30 amino acids in length.
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Protein Domain
IPR009198
Name: Uncharacterised conserved protein UCP014484, transmembrane
Type: Family
Description: There are currently no experimental data for members of this group or their homologues. However, these proteins are predicted to contain three or more transmembrane segments.
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Protein Domain
IPR022178
Name: Protein of unknown function DUF3709
Type: Family
Description: This domain family is found in bacteria, and is approximately 30 amino acids in length. There are two conserved sequence motifs: RCLMK and LIEL.
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Protein Domain
IPR022179
Name: Cilia- and flagella-associated protein 276
Type: Family
Description: This family of proteins is found in eukaryotes. There is a single completely conserved residue D that may be functionally important. The family includes CFAP276 and homologues. Bovin CFAP276 has been identified as a microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating [ ]. Members of this family have been suggested to be involved in intracellular Ca2 homeostasis [].
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Protein Domain
IPR046139
Name: Protein of unknown function DUF6141
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea.
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Protein Domain
IPR046138
Name: Protein of unknown function DUF6140
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found imainly in Bacteroidetes.
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Protein Domain
IPR046137
Name: Protein of unknown function DUF6139
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found predominantly in Betaproteobacteria. There are two conserved sequence motifs: EATN and KGYAI.
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Protein Domain
IPR046136
Name: Protein of unknown function DUF6138
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000452) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the tyrocidine biosynthetic gene cluster from Brevibacillus brevis NBRC 100599 and appears to be predominantly found in bacteria [ ].
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