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Search results 5901 to 6000 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR046025
Name: Protein of unknown function DUF5983
Type: Family
Description: This family of proteins mostly found in proteobacteria are likely to be phage derived.
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Protein Domain
IPR046024
Name: Protein of unknown function DUF5982
Type: Domain
Description: This short domain of unknown function is found at the N terminus of PF01103.
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Protein Domain
IPR046023
Name: Protein of unknown function DUF5980
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000666) is described by MIBiG as an example of the following biosynthetic class, terpene.
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Protein Domain
IPR046021
Name: Protein of unknown function DUF5978
Type: Domain
Description: This presumed domain is found as highly identical tandem repeats in bacterial cell surface proteins associated with Bact_lectin.
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Protein Domain
IPR046020
Name: Protein of unknown function DUF5977
Type: Domain
Description: Domain found as tandem repeats in bacterial surface proteins, commonly associated with PA14 adhesive domain.
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Protein Domain
IPR022053
Name: Protein of unknown function DUF3613
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 126 amino acids in length.
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Protein Domain
IPR022055
Name: Protein of unknown function DUF3612
Type: Family
Description: This domain family is found in bacteria, and is approximately 180 amino acids in length. The family is found in association with .
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Protein Domain
IPR022054
Name: Protein of unknown function DUF3614
Type: Family
Description: This family of proteins is found in viruses. Proteins in this family are typically between 162 and 495 amino acids in length.
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Protein Domain
IPR022059
Name: Protein of unknown function DUF3615
Type: Family
Description: This domain family is found in bacteria and eukaryotes, and is typically between 86 and 97 amino acids in length. There is a conserved FAE sequence motif. There is a single completely conserved residue F that may be functionally important.
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Protein Domain
IPR046019
Name: Protein of unknown function DUF5976
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000624) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046018
Name: Protein of unknown function DUF5975
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000486) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046017
Name: Protein of unknown function DUF5974
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000576) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046016
Name: Protein of unknown function DUF5973
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001577) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046015
Name: Protein of unknown function DUF5972
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001634) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046014
Name: Protein of unknown function DUF5971
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001555) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046013
Name: Protein of unknown function DUF5970
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000616) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046012
Name: Protein of unknown function DUF5969
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000604) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046011
Name: Protein of unknown function DUF5967
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000571) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046010
Name: Protein of unknown function DUF5966
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000498) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046009
Name: Protein of unknown function DUF5965
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000561) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046008
Name: Protein of unknown function DUF5964
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000523) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046007
Name: Protein of unknown function DUF5963
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001171) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046006
Name: Protein of unknown function DUF5962
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000498) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046005
Name: Protein of unknown function DUF5961
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000573) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046004
Name: Protein of unknown function DUF5960
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000561) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046003
Name: Protein of unknown function DUF5959
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001707) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046002
Name: Protein of unknown function DUF5958
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001920) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
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Protein Domain
IPR046001
Name: Protein of unknown function DUF5957
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001062) is described by MIBiG as an example of the following biosynthetic class, polyketide.
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Protein Domain
IPR046000
Name: Protein of unknown function DUF5956
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001073) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide.
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Protein Domain
IPR046079
Name: Protein of unknown function DUF6097
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001796) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the tauramamide biosynthetic gene cluster from Brevibacillus laterosporus DSM 25 and appears to be predominantly found in bacteria [ ].
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Protein Domain
IPR046078
Name: Protein of unknown function DUF6096
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins of this family are found in bacteria and viruses.
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Protein Domain
IPR046077
Name: Protein of unknown function DUF6095
Type: Family
Description: This family of predicted integral membrane proteins is functionally uncharacterised. This family of proteins is found in Bacteroidetes.
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Protein Domain
IPR046075
Name: Protein of unknown function DUF6093
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus and appears to be predominantly found in Actinobacteria [ ].
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Protein Domain
IPR046074
Name: Protein of unknown function DUF6092
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001986) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a member from the purincyclamide biosynthetic gene cluster from Streptomyces chrestomyceticus and appears to be predominantly found in bacteria and archaea.
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Protein Domain
IPR046073
Name: Protein of unknown function DUF6032
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001410) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the polysaccharide A biosynthetic gene cluster from Bacteroides fragilis [ ].
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Protein Domain
IPR046072
Name: Protein of unknown function DUF6031
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This family (BGC0000919 in MIBiG) includes a protein from the phaseolotoxin biosynthetic gene cluster from Pseudomonas syringae and appears to be predominantly found in bacteria [ ].
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Protein Domain
IPR046071
Name: Protein of unknown function DUF6030
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000762) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the exopolysaccharide biosynthetic gene cluster from Rhizobium leguminosarum bv. viciae and appears to be predominantly found in proteobacteria [ ].
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Protein Domain
IPR046070
Name: Protein of unknown function DUF6029
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are typically between 531 and 570 amino acids in length. There is a conserved GGVCR sequence motif.
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Protein Domain
IPR046069
Name: Protein of unknown function DUF6027
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This family (BGC0001387 in MIBiG) includes a protein from the nucleocidin biosynthetic gene cluster from Streptomyces calvus and appear to be predominantly found in Actinobacteria and Chloroflexi [ ].
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Protein Domain
IPR046068
Name: Protein of unknown function DUF6026
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001285) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the pseudopyronine A biosynthetic gene cluster from Pseudomonas putida and appears to be predominantly found in Pseudomonas [ ].
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Protein Domain
IPR046067
Name: Protein of unknown function DUF6025
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000938) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the fosfomycin biosynthetic gene cluster from Streptomyces fradiae [ , ].
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Protein Domain
IPR046066
Name: Protein of unknown function DUF6024
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001992) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the thioguanine biosynthetic gene cluster from Erwinia amylovora CFBP1430 [ ].
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Protein Domain
IPR046065
Name: Protein of unknown function DUF6023
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001077) is described by MIBiG as an example of the following biosynthetic classes, polyketide and terpene. This family includes a protein from the alkyl-O-dihydrogeranyl- methoxyhydroquinones biosynthetic gene cluster from Actinoplanes missouriensis 431 and appears to be predominantly found in Actinobacteria [ ].
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Protein Domain
IPR046064
Name: Protein of unknown function DUF6022
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000693) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the butirosin A biosynthetic gene cluster from Bacillus circulans and appears to be predominantly found in Bacilli [ , ].
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Protein Domain
IPR046063
Name: Protein of unknown function DUF6021
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000399) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the orfamide A biosynthetic gene cluster from Pseudomonas protegens Pf-5 and appears to be predominantly found in Pseudomonadaceae [ ].
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Protein Domain
IPR046062
Name: Protein of unknown function DUF6020
Type: Family
Description: This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found mainly in Firmicutes and Actinobacteria. Proteins in this family are typically between 587 and 710 amino acids in length.
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Protein Domain
IPR046061
Name: Protein of unknown function DUF6019
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is predominantly found in Clostridia. Proteins in this family have a single transmembrane helix.
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Protein Domain
IPR046060
Name: Protein of unknown function DUF6018
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000320) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the cereulide biosynthetic gene cluster from Bacillus cereus and appears to be predominantly found in Bacilli [ , ].
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Protein Domain
IPR022090
Name: Protein of unknown function DUF3634
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.
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Protein Domain
IPR022095
Name: Rickettsia outer membrane protein B
Type: Family
Description: This domain family is found in bacteria, and is approximately 220 amino acids in length. The family is found in association with . This family is the middle region of one of the outer membrane proteins of Rickettsia which is involved in adhesion to eukaryotic cells for uptake.
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Protein Domain
IPR022098
Name: Protein of unknown function DUF3637
Type: Family
Description: This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with , .
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Protein Domain
IPR046057
Name: Protein of unknown function DUF6015
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found predominantly in archaea.
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Protein Domain
IPR034072
Name: DNA-binding protein SMUBP-2, R3H domain
Type: Domain
Description: This is the R3H domain of Smubp-2, also known as immunoglobulin mu-binding protein 2 (IGHMBP2) [ ]. Smubp-2 also contains a helicase and an AN1-like zinc finger domain and has been shown to bind single-stranded DNA [, ].The R3H domain is a conserved sequence motif found in proteins from a diverse range of organisms including eubacteria, green plants, fungi and various groups of metazoans, but not in archaea and Escherichia coli. The domain is named R3H because it contains an invariant arginine and a highly conserved histidine, that are separated by three residues. It also displays a conserved pattern of hydrophobic residues, prolines and glycines. It can be found alone, in association with AAA domain or with various DNA/RNA binding domains like DSRM, KH, G-patch, PHD, DEAD box, or RRM. The functions of these domains indicate that the R3H domain might be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA [ ].The 3D structure of the R3H domain has been solved. The fold presents a small motif, consisting of a three-stranded antiparallel β-sheet, against which two α-helices pack from one side. This fold is related to the structures of the YhhP protein and the C-terminal domain of the translational initiation factor IF3. Three conserved basic residues cluster on the same face of the R3H domain and could play a role in nucleic acid recognition. An extended hydrophobic area at a different site of the molecular surface could act as a protein-binding site [ ].
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Protein Domain
IPR046056
Name: Protein of unknown function DUF6014
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000332) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the cyanopeptolin biosynthetic gene cluster from Microcystis sp. NIVA-CYA 172/5 and appears to be predominantly found in Cyanobacteria [ ].
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Protein Domain
IPR046055
Name: Protein of unknown function DUF6013
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001120) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from the burkholderic acid biosynthetic gene cluster from Burkholderia thailandensis E264 and appears to be predominantly found in Burkholderiaceae [ , ].
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Protein Domain
IPR046054
Name: Protein of unknown function DUF6012
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000128) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein encoded by the pyoluteorin biosynthetic gene cluster from Pseudomonas sp. M18 [ , ].
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Protein Domain
IPR046053
Name: Protein of unknown function DUF6011
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000413) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein encoded by the pyoverdin biosynthetic gene cluster from Pseudomonas protegens Pf-5 [ , ].
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Protein Domain
IPR046052
Name: Protein of unknown function DUF6010
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001011) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from the meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748 [ ].
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Protein Domain
IPR034077
Name: FKBP12-associated protein 1, R3H domain
Type: Domain
Description: This R3H domain is found in yeast FKBP12-associated protein 1 (FAP1). FAP1 confers resistance to rapamycin by competing with the drug for binding to prolyl isomerase FKBP12. FAP1 encodes a putative transcription factor which belongs to a conserved family that includes human NF-X1 [ ].The R3H domain is a conserved sequence motif found in proteins from a diverse range of organisms including eubacteria, green plants, fungi and various groups of metazoans, but not in archaea and Escherichia coli. The domain is named R3H because it contains an invariant arginine and a highly conserved histidine, that are separated by three residues. It also displays a conserved pattern of hydrophobic residues, prolines and glycines. It can be found alone, in association with AAA domain or with various DNA/RNA binding domains like DSRM, KH, G-patch, PHD, DEAD box, or RRM. The functions of these domains indicate that the R3H domain might be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA [ ].The 3D structure of the R3H domain has been solved. The fold presents a small motif, consisting of a three-stranded antiparallel β-sheet, against which two α-helices pack from one side. This fold is related to the structures of the YhhP protein and the C-terminal domain of the translational initiation factor IF3. Three conserved basic residues cluster on the same face of the R3H domain and could play a role in nucleic acid recognition. An extended hydrophobic area at a different site of the molecular surface could act as a protein-binding site [ ].
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Protein Domain
IPR046051
Name: Protein of unknown function DUF6009
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000965) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the C-1027 biosynthetic gene cluster from Streptomyces globisporus [, ].
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Protein Domain
IPR046050
Name: Protein of unknown function DUF6008
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000112) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus subsp. neocarzinostaticus [ ] and appears to be restricted to Actinobacteria.
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Protein Domain
IPR034079
Name: RNA-binding protein KhpB, R3H domain
Type: Domain
Description: R3H domain found in proteins homologous to Bacillus subtilis RNA-binding protein KhpB (also known as Jag/EloR), which is associated with SpoIIIJ [ ]. SpoIIIJ is necessary for the third stage of sporulation [, ]. It forms a complex with KhpA which binds to cellular RNA and controls its expression. It also plays a role in peptidoglycan (PG) homeostasis and cell length regulation []. The R3H domain is a conserved sequence motif found in proteins from a diverse range of organisms including eubacteria, green plants, fungi and various groups of metazoans, but not in archaea and Escherichia coli. The domain is named R3H because it contains an invariant arginine and a highly conserved histidine, that are separated by three residues. It also displays a conserved pattern of hydrophobic residues, prolines and glycines. It can be found alone, in association with AAA domain or with various DNA/RNA binding domains like DSRM, KH, G-patch, PHD, DEAD box, or RRM. The functions of these domains indicate that the R3H domain might be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA [ ].The 3D structure of the R3H domain has been solved. The fold presents a small motif, consisting of a three-stranded antiparallel β-sheet, against which two α-helices pack from one side. This fold is related to the structures of the YhhP protein and the C-terminal domain of the translational initiation factor IF3. Three conserved basic residues cluster on the same face of the R3H domain and could play a role in nucleic acid recognition. An extended hydrophobic area at a different site of the molecular surface could act as a protein-binding site [ ].
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Protein Domain
IPR022080
Name: Protein of unknown function DUF3630
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue D that may be functionally important.
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Protein Domain
IPR022085
Name: Oxopyrrolidines biosynthesis cluster protein G
Type: Family
Description: This family includes oxopyrrolidines biosynthesis cluster protein G (OpdG) which is part of the gene cluster that mediates the biosynthesis of oxopyrrolidines, polyketide-amino acid hybrid compounds with feature structures of tetramic acid [ ].
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Protein Domain
IPR046049
Name: Protein of unknown function DUF6007
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000758) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the capsular polysaccharide biosynthetic gene cluster from Staphylococcus aureus [ ].
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Protein Domain
IPR046048
Name: Protein of unknown function DUF6006
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001016) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from then microcystin biosynthetic gene cluster from Anabaena sp. 90 [ ].
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Protein Domain
IPR046047
Name: Protein of unknown function DUF6005
Type: Family
Description: This entry represents a member of a bacterial biosynthetic gene cluster (BGC0000942 in the MIBiG database). This family includes a protein from the petrobactin biosynthetic gene cluster from Bacillus anthracis str. Ames [ ].
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Protein Domain
IPR046046
Name: Protein of unknown function DUF6004
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000033) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the calicheamicin biosynthetic gene cluster from Micromonospora echinospora [ ].
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Protein Domain
IPR046045
Name: Protein of unknown function DUF6003
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000100) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from monensin biosynthetic gene cluster from Streptomyces cinnamonensis [].
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Protein Domain
IPR046044
Name: Protein of unknown function DUF6002
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000833) is described by MIBiG as an example of the following biosynthetic classes, saccharide and other (unspecified). This family includes a protein from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis [ ].
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Protein Domain
IPR046043
Name: Protein of unknown function DUF6001
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000919) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the phaseolotoxin biosynthetic gene cluster from Pseudomonas syringae [ ].
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Protein Domain
IPR046042
Name: Protein of unknown function DUF6000
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000026) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the avilamycin A biosynthetic gene cluster from Streptomyces viridochromogenes Tue57 and appears to be predominantly found in bacteria [ ].
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Protein Domain
IPR046041
Name: Protein of unknown function DUF5999
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus [ ]. This family appears to be predominantly found in Actinobacteria.
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Protein Domain
IPR046040
Name: Protein of unknown function DUF5998
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001522) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the auroramycin biosynthetic gene cluster from Streptomyces filamentosus [ ]. Some members of this family have been identified as putative phosphodiesterases.
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Protein Domain
IPR046099
Name: Protein of unknown function DUF6035
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in Proteobacteria and Bacteroidetes. There is a conserved GVD sequence motif. This family contains a PD-(D/E)XK nuclease domain.
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Protein Domain
IPR046098
Name: Protein of unknown function DUF6034
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Clostridia.
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Protein Domain
IPR046097
Name: Protein of unknown function DUF6033
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is primarily found in Clostridia. Proteins in this family are typically between 212 and 271 amino acids in length.
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Protein Domain
IPR046096
Name: Protein of unknown function DUF6114
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000696) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the gentamicin biosynthetic gene cluster from Micromonospora echinospora and appears to be predominantly found in Actinobacteria and Firmicutes [ , ].
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Protein Domain
IPR046095
Name: Protein of unknown function DUF6113
Type: Family
Description: This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 154 amino acids in length.
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Protein Domain
IPR046094
Name: Protein of unknown function DUF6112
Type: Family
Description: This family of putative integral membrane proteins is functionally uncharacterised. Proteins of this family are mainly found in Actinobacteria.
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Protein Domain
IPR046093
Name: Protein of unknown function DUF6111
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins of this family are predominantly found in Alphaproteobacteria.
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Protein Domain
IPR046092
Name: Protein of unknown function DUF6110
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found primarily in Firmicute bacteria.
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Protein Domain
IPR046091
Name: Protein of unknown function DUF6109
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000069) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the gephyronic acid biosynthetic gene cluster from Archangium violaceum Cb vi76 and appears to be predominantly found in bacteria [ ].
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Protein Domain
IPR046090
Name: Protein of unknown function DUF6108
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Bacteroidetes.
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Protein Domain
IPR046089
Name: Protein of unknown function DUF6107
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Alphaproteobacteria.
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Protein Domain
IPR046088
Name: Protein of unknown function DUF6106
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is predominantly found in Firmicutes. This protein is distantly related to PF14256.
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Protein Domain
IPR046087
Name: Protein of unknown function DUF6105
Type: Family
Description: This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found predominantly in Alphaproteobacteria.
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Protein Domain
IPR046086
Name: Protein of unknown function DUF6104
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is predominantly found in Actinobacteria.
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Protein Domain
IPR046085
Name: Protein of unknown function DUF6103
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Firmicute bacteria.
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Protein Domain
IPR046084
Name: Protein of unknown function DUF6102
Type: Family
Description: This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found in Firmicute bacteria.
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Protein Domain
IPR046083
Name: Protein of unknown function DUF6101
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found primarily in Alphaproteobacteria.
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Protein Domain
IPR046082
Name: Protein of unknown function DUF6100
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in Firmicutes.
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Protein Domain
IPR046081
Name: Protein of unknown function DUF6099
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000222) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the FD-594 biosynthetic gene cluster from Streptomyces sp. TA-0256 and it appears to be predominantly found in Actinobacteria [ ].
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Protein Domain
IPR046080
Name: Protein of unknown function DUF6098
Type: Family
Description: This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000847) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the thienamycin biosynthetic gene cluster from Streptomyces cattleya and it appears to be predominantly found in Actinobacteria [ ].
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Protein Domain
IPR000968
Name: Influenza nuclear export protein NS2
Type: Family
Description: The Influenza A virus belongs to the class of ssRNA negative-strand viruses. Influenza virus NS2 protein (also known as NEP) has an important role in the nucleocytoplasmic transport of the viral ribonucleoprotein. The NS2 proteins perform this function in virus-infected cells by interacting with nuclear pore complex components of the host cell [ ]. It is also involved in important functions during influenza virus replication. Regulation of viral RNA transcription and replication by NS2 was shown to be an important factor in the adaptation of highly pathogenic avian H5N1 influenza viruses to the mammalian host [].
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Protein Domain
IPR009303
Name: Protein of unknown function DUF960
Type: Family
Description: This family consists of several hypothetical proteins from several species of bacteria. The function of this family is unknown.
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Protein Domain
IPR009306
Name: Protein of unknown function DUF963
Type: Repeat
Description: This family consists of a series of repeated sequences from one hypothetical protein ( ) found in Schizosaccharomyces pombe. The function of this family is unknown.
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Protein Domain
IPR009307
Name: Bacterial microcompartment shell protein EutS/PduU/CutR
Type: Family
Description: Bacterial microcompartments (BCMs) function as organelles by sequestering particular metabolic processes within the cell. The shells of varied microcompartments are built primarily from small proteins belonging to the BMC domain family.This family represents Bacterial microcompartment shell protein EutS, PduU and CutR, all of them components of the BMC.PduU is minor shell protein of the BMC dedicated to the coenzyme B12-dependent degradation of 1,2-propanediol (1,2-PD) [ , ]. This protein exists as a hexamer which might further assemble into the flat facets of the polyhedral outer shell of the pdu microcompartments []. The core of PduU is related to the typical bacterial BMC domain and its natural oligomeric state is a cyclic hexamer. Unlike other typical BMC domain proteins, the 3D topology of PduU reveals a circular permuted variation on the typical BMC fold which leads to several unique features. The exact functions related to those unique features are still not clear. Another difference is the presence of a deep cavity on one side of the hexamer as well as an intermolecular six-stranded beta barrel that seems to block the central pore that is present in other BMC domain proteins.EutS proteins included in this family are sequence homologues of PduU. They are encoded within eut operon and may be required for the formation of the outer shell of bacterial eut polyhedral organelles which are involved in the cobalamin-dependent degradation of ethanolamine [ , ].CutR is a minor shell protein of the choline degradation-specific BMC. It may play a key role in conferring heterogeneity and flexibility in this BMC [ ].
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Protein Domain
IPR036904
Name: Phycobilisome degradation protein NblA superfamily
Type: Homologous_superfamily
Description: In the cyanobacterium Synechococcus species PCC 7942 ( ), nblA triggers degradation of light-harvesting phycobiliproteins in response to deprivation nutrients including nitrogen, phosphorus and sulphur. The mechanism of nblA function is not known, but it has been hypothesised that nblA may act by disrupting phycobilisome structure, activating a protease or tagging phycobiliproteins for proteolysis. Members of this domain superfamily have also been identified in the chloroplasts of some red algae. The structure of the nblA domain is composed of four helices arranged as dimer of identical alpha-hairpin subunits with open bundle.
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Protein Domain
IPR024921
Name: Protein-export membrane protein SecF, archaeal
Type: Family
Description: Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocasepathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component []. From there, the mature proteins are either targeted to the outermembrane, or remain as periplasmic proteins. The translocase protein subunits are encoded on the bacterial chromosome. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integralmembrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF) []. The chaperone protein SecB [] is a highly acidic homotetrameric protein that exists as a "dimer of dimers"in the bacterial cytoplasm. SecB maintains preproteins in an unfolded state after translation, and targets these to the peripheral membraneprotein ATPase SecA for secretion [ ]. Together with SecY and SecG, SecE forms a multimericchannel through which preproteins are translocated, using both proton motive forces and ATP-driven secretion. The latter is mediated by SecA. The structure of theEscherichia coli SecYEG assembly revealed a sandwich of two membranes interacting through the extensive cytoplasmic domains []. Each membrane is composed of dimers of SecYEG. The monomeric complex contains 15transmembrane helices. The SecD and SecF equivalents of the Gram-positive bacterium Bacillus subtilis are jointly present in one polypeptide,denoted SecDF, that is required to maintain a high capacity for protein secretion. Unlike the SecD subunit of the pre-protein translocase of E. coli, SecDFof B. subtilis was not required for the release of a mature secretory protein from the membrane, indicating that SecDF is involved in earlier translocation steps [].Comparison with SecD and SecF proteins from other organisms revealed the presence of 10 conservedregions in SecDF, some of which appear to be important for SecDF function. Interestingly, the SecDF protein of B. subtilis has 12 putative transmembranedomains. Thus, SecDF does not only show sequence similarity but also structural similarity to secondary solute transporters [].This family consists of various archaeal SecF proteins. They show a high degree of structural and functional similarity to their bacterial homologues, despite the different composition of their translocation machineries [ ].
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