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Search results 6301 to 6400 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR022564
Name: Protein of unknown function DUF2678
Type: Family
Description: This family of proteins has no known function.
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Protein Domain
IPR022566
Name: Protein of unknown function DUF2613
Type: Family
Description: This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.
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Protein Domain
IPR046522
Name: Protein of unknown function DUF6699
Type: Family
Description: This entry represents a family of uncharacterised fungal proteins
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Protein Domain
IPR046521
Name: Protein of unknown function DUF6698
Type: Family
Description: This entry represents an uncharacterised family of fungal proteins.
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Protein Domain
IPR022568
Name: Protein of unknown function DUF2824
Type: Family
Description: This family of proteins has no known function. Members of the family are found in P22-like viruses and bacteria. Some of the phage members have been annotated as head assembly proteins, but this has not been confirmed.
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Protein Domain
IPR046520
Name: Protein of unknown function DUF6697
Type: Domain
Description: This entry represents a fungal domain of unknown function.
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Protein Domain
IPR010593
Name: Protein of unknown function DUF1159
Type: Family
Description: This entry consists of several hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR010590
Name: Protein of unknown function DUF1158
Type: Family
Description: This family consists of several enterobacterial YbdJ proteins. The function of this family is unknown
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Protein Domain
IPR034543
Name: Long chronological lifespan protein 2
Type: Family
Description: This family of yeast proteins has no known function. Mutants have a long chronological lifespan [ ] and genetic interactions suggest that LCL2/ YLR104W is a novel component of ERAD (endoplasmic reticulum-associated degradation pathway) [].
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Protein Domain
IPR010595
Name: Protein of unknown function DUF1161
Type: Family
Description: This family consists of several short, hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR046599
Name: Protein of unknown function DUF6658
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 198 amino acids in length.
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Protein Domain
IPR046598
Name: Protein of unknown function DUF6657
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
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Protein Domain
IPR046597
Name: Protein of unknown function DUF6656
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
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Protein Domain
IPR046596
Name: Protein of unknown function DUF6655
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 205 and 301 amino acids in length.
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Protein Domain
IPR046595
Name: Protein of unknown function DUF6653
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 149 and 172 amino acids in length.
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Protein Domain
IPR046594
Name: Protein of unknown function DUF6652
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 189 and 210 amino acids in length.
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Protein Domain
IPR046592
Name: Protein of unknown function DUF6650
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 150 and 175 amino acids in length.
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Protein Domain
IPR046591
Name: Protein of unknown function DUF6649
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 268 amino acids in length.
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Protein Domain
IPR046590
Name: Protein of unknown function DUF6648
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 180 amino acids in length.
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Protein Domain
IPR046589
Name: Protein of unknown function DUF6647
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 158 and 180 amino acids in length.
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Protein Domain
IPR046588
Name: Protein of unknown function DUF6646
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length.
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Protein Domain
IPR046585
Name: Protein of unknown function DUF6643
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 144 and 171 amino acids in length.
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Protein Domain
IPR046584
Name: Protein of unknown function DUF6642
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 186 and 200 amino acids in length.
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Protein Domain
IPR046583
Name: Protein of unknown function DUF6631
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 132 and 168 amino acids in length.
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Protein Domain
IPR046582
Name: Protein of unknown function DUF6630
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 168 and 270 amino acids in length.
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Protein Domain
IPR046581
Name: Protein of unknown function DUF6641
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.
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Protein Domain
IPR046580
Name: Protein of unknown function DUF6640
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 133 and 156 amino acids in length.
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Protein Domain
IPR046579
Name: Protein of unknown function DUF6639
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 218 and 231 amino acids in length.
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Protein Domain
IPR046578
Name: Protein of unknown function DUF6638
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 412 and 454 amino acids in length.
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Protein Domain
IPR046577
Name: Protein of unknown function DUF6637
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.
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Protein Domain
IPR046576
Name: Protein of unknown function DUF6636
Type: Family
Description: This bacterial family of proteins is functionally uncharacterised.
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Protein Domain
IPR046575
Name: Protein of unknown function DUF6635
Type: Family
Description: This entry represents a family of proteins that is functionally uncharacterised. This family of proteins is found in bacteria.
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Protein Domain
IPR046574
Name: Protein of unknown function DUF6634
Type: Family
Description: This entry represents a family of proteins predominantly found in Proteobacteria that is functionally uncharacterised.
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Protein Domain
IPR046573
Name: Protein of unknown function DUF6633
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Bacteroidetes. Proteins in this family are typically between 148 and 213 amino acids in length.
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Protein Domain
IPR046572
Name: Protein of unknown function DUF6632
Type: Family
Description: This entry represents a family of proteins that is functionally uncharacterised. This family of proteins is mainly found in bacteria. Proteins in this family are typically between 127 and 139 amino acids in length.
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Protein Domain
IPR046571
Name: Protein of unknown function DUF6725
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.
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Protein Domain
IPR046570
Name: Protein of unknown function DUF6724
Type: Family
Description: This entry represents a family of proteins predominantly found in Actinobacteria. Members are functionally uncharacterised.
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Protein Domain
IPR034596
Name: 39S ribosomal protein L52, mitochondrial
Type: Family
Description: Mitochondria contain 55S ribosomes, with a 28S subunit and a 39S subunit. These ribosomes resemble bacterial ribosomes and eukaryotic-cytoplasmic ribosomes in their main functional properties, but they differ in structure and physical chemical properties. Many of the mitochondrial ribosomal proteins (MRPs) are distinctive, having no closely related homologues in bacterial or eukaryotic-cytoplasmic ribosomes. MRPL52 is one of these [ ].
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Protein Domain
IPR046569
Name: Protein of unknown function DUF6723
Type: Family
Description: This entry represents a family of proteins found in bacteria that is functionally uncharacterised. Proteins in this family are typically between 81 and 125 amino acids in length.
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Protein Domain
IPR046568
Name: Protein of unknown function DUF6722
Type: Family
Description: This entry represents a family of proteins that is functionally uncharacterised. Members are predominantly found in bacteria.
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Protein Domain
IPR046566
Name: Protein of unknown function DUF6720
Type: Family
Description: This entry represents a family of proteins is functionally uncharacterised. This family of proteins is found in fungi.
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Protein Domain
IPR046565
Name: Protein of unknown function DUF6719
Type: Family
Description: This family is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are typically 74 amino acids in length.
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Protein Domain
IPR046564
Name: Protein of unknown function DUF6718
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
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Protein Domain
IPR046563
Name: Protein of unknown function DUF6715
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length. Members in this entry appear to belong to the NTF2 superfamily.
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Protein Domain
IPR046562
Name: Protein of unknown function DUF6717
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 115 amino acids in length.
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Protein Domain
IPR046561
Name: Protein of unknown function DUF6716
Type: Family
Description: This entry represents a group of uncharacterised proteins that belong to the GT- superfamily of glycosyltransferases.
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Protein Domain
IPR046560
Name: Protein of unknown function DUF6714
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 150 and 185 amino acids in length.
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Protein Domain
IPR034581
Name: Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12
Type: Family
Description: PTAC12, also known as HEMERA (HMR), has been shown in both rice and Arabidopsis to be involved in chloroplast development [ , ]. Furthermore, PTAC12/HMR has a function in the nucleus, where it acts specifically in phytochrome signalling []. It is essential for both phytochrome B localization to photobodies and PIF (phytochrome-interacting factor) degradation. Photoactivated phytochromes directly interact with HMR and promote HMR accumulation, which in turn mediates the formation of photobodies and the degradation of PIF transcription factors to trigger photomorphogenesis [].
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Protein Domain
IPR034584
Name: Testis, prostate and placenta-expressed protein
Type: Family
Description: TEPP is specifically expressed in testis, prostate, and placenta, and might have a role in reproductive biology [ ].
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Protein Domain
IPR010601
Name: Protein of unknown function DUF1182
Type: Family
Description: This family consists of several hypothetical proteins of around 360 residues in length and seems to be specific to Caenorhabditis elegans. The function of this family is unknown.
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Protein Domain
IPR010602
Name: Protein of unknown function DUF1186
Type: Family
Description: This family consists of several hypothetical bacterial proteins of around 250 residues in length and is found in several Chlamydia and Anabaena species. The function of this family is unknown.
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Protein Domain
IPR010607
Name: Protein of unknown function DUF1194
Type: Family
Description: This family consists of several hypothetical Rhizobiales specific proteins of around 270 residues in length. The function of this family is unknown.
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Protein Domain
IPR009625
Name: FeGP cofactor biosynthesis protein HcgF
Type: Family
Description: This archaeal family includes the iron guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF which catalyses the transesterification of AMP-GP to afford a Cys (HcgF)-S-GP thioester [ ].
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Protein Domain
IPR010610
Name: Erythromycin biosynthesis protein CIII-like, central
Type: Domain
Description: This entry represents a conserved region found in Erythromycin biosynthesis protein CIII (EryCIII) from Saccharopolyspora erythraea and similar bacterial proteins. EryCIII is organised into two domains, both of them with a Rossmann-like α/β fold [ ].
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Protein Domain
IPR009414
Name: Protein of unknown function DUF1064
Type: Family
Description: This entry includes Bacteriophage 92, Orf34. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.This family consists of several phage and bacterial proteins whose functions have not been experimentally determined. Computational analysis involving sequence, predicted structure and genomic context suggests that these proteins may be endonucleases which function in phage genome segregation, or the repair of double-stranded breaks introduced during either this process or DNA replication [ ].
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Protein Domain
IPR010406
Name: Protein of unknown function DUF1003
Type: Family
Description: This entry consists of several hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR009418
Name: Protein of unknown function DUF1067
Type: Family
Description: This family consists of several hypothetical Mycobacterium leprae specific proteins. The function of this family is unknown.
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Protein Domain
IPR009412
Name: Protein of unknown function DUF1062
Type: Family
Description: This entry consists of several hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR010413
Name: Intracellular heme transport protein HutX-like
Type: Family
Description: HutX is a member of the conserved heme utilization operon from pathogenic E. coli, and includes ChuS, HutX, HuvX, HugX, and ShuX in proteobacteria, among others. It forms a dimer which displays a very similar fold and organization to the monomeric structure of other heme utilization proteins such as HemS, ChuS, HmuS, PhuS; these latter occurring as duplicated domains. They all bind heme via a key conserved histidine. The genes encoded within these heme utilization operons enable the effective uptake and utilization of heme as an iron source in pathogenic microorganisms to enable multiplication and survival within hosts they invade [ ].In E. coli O157:H7, HutX forms a dimer with a very similar fold to the monomer structure of two other heme utilization proteins, ChuS and HemS, despite low sequence homology. ChuX has been shown to bind heme in a 1:1 manner, inferring that the ChuX homodimer could coordinate two heme molecules in contrast to only one heme molecule bound in ChuS and HemS [ , ]. In Vibrio cholera, HutX is an intracellular heme transport protein for the heme-degrading enzyme, HutZ. It forms a dimer, each domain binding heme that is transferred from HutX to HutZ via a specific protein-protein interaction [ , ]. This family also includes AGR_C_4470p from Agrobacterium tumefaciens and found to be a dimer, with each subunit having strong structural homology and organization to the heme utilization protein ChuS from Escherichia coli and HemS from Yersinia enterocolitica. However, the heme binding site is not conserved in AGR_C_4470p, suggesting a possible different function [ ].
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Protein Domain
IPR010416
Name: Protein of unknown function DUF1010
Type: Family
Description: This is a family of plasmid encoded proteins with unknown function.
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Protein Domain
IPR009403
Name: Protein of unknown function UPF0637
Type: Family
Description: This entry consists of several hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR009406
Name: Protein of unknown function DUF1056
Type: Family
Description: This family consists of several proteins of unknown function from tailed bacteriophages and Firmicutes, including putative head-tail joining bacteriophage proteins.
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Protein Domain
IPR009409
Name: Protein of unknown function DUF1059
Type: Family
Description: This entry consists of short hypothetical archaeal and bacterial proteins of unknown function.
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Protein Domain
IPR010441
Name: CH-like domain in sperm protein
Type: Domain
Description: This entry represents a domain known as Spef, which is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum [ ]. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear []. Transcription aberrations leading to a truncated protein result in immotile sperm [].
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Protein Domain
IPR009436
Name: Type-1 angiotensin II receptor-associated protein
Type: Family
Description: AGTRAP (type-1 angiotensin II receptor-associated protein) appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation [ ]. It plays an important role in cardiac hypertrophy [].
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Protein Domain
IPR010427
Name: Protein of unknown function DUF1023
Type: Family
Description: This is a family of uncharacterised proteins found in Actinobacteria. Computational analysis suggests that they may belong to the α-β hydrolase family of enzymes, as they are predicted to form the core secondary structures and catalytic machinery common to these proteins [ ]. Genomic context suggests that they may function as lipases, controlling the concentration of their putative phospholipid substrates.
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Protein Domain
IPR009432
Name: Protein of unknown function DUF1075
Type: Family
Description: This family consists of several eukaryotic proteins of unknown function.
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Protein Domain
IPR009446
Name: Mitochondrial genome maintenance protein Mgm101
Type: Family
Description: The Mgm101 is a Rad52-type single-stranded annealing protein (SSAP) required for mitochondrial DNA (mtDNA) repair and maintenance. Its C-terminal tail is required for single-stranded DNA binding [ ]. It may also play roles in the replication of the mitochondrial genome and the maintenance of its telomeres [].
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Protein Domain
IPR010434
Name: Protein of unknown function DUF1033
Type: Family
Description: This family consists of several hypothetical bacterial proteins.
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Protein Domain
IPR009443
Name: Nuclear pore complex interacting protein
Type: Family
Description: This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans [ ].
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Protein Domain
IPR010430
Name: Protein of unknown function DUF1028
Type: Family
Description: This is a family of bacterial and archaeal proteins with unknown function.
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Protein Domain
IPR009494
Name: Protein of unknown function DUF1108
Type: Family
Description: This entry includes Bacteriophage 92, Orf49. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.This family consists of several bacterial proteins from Staphylococcus aureus as well as a number of phage proteins. The function of this family is unknown.
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Protein Domain
IPR022475
Name: Uncharacterised protein family UPF0273, KaiC-like
Type: Family
Description: Members of this family contain a single copy of the KaiC domain that occurs in two copies of the circadian clock protein kinase KaiC itself. Members occur primarily in archaea and in Thermotogales.
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Protein Domain
IPR009499
Name: Protein of unknown function DUF1116
Type: Family
Description: This family contains hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR022465
Name: Terminal organelle assembly protein TopJ
Type: Family
Description: This entry describes TopJ (MG_200, CbpA), a DnaJ homologue and probable assembly protein of the Mycoplasma terminal organelle. The terminal organelle is involved in both cytadherence and gliding motility [ ].
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Protein Domain
IPR010466
Name: Protein of unknown function DUF1058
Type: Family
Description: SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [ , ]. They are found in a great variety of intracellular or membrane-associated proteins [, , ] for example, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin binding protein ABP-1.The SH3 domain has a characteristic fold which consists of five or six β-strands arranged as two tightly packed anti-parallel β-sheets. The linker regions may contain short helices. The surface of the SH3-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [ ].This family consists of several hypothetical bacterial proteins of unknown function, but that contain an SH-3 region.
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Protein Domain
IPR022451
Name: Conserved hypothetical protein CHP03829, YokU
Type: Family
Description: Members of this protein family occur in various species of the genus Bacillus, always next to the gene (kamA or ablA) for lysine 2,3-aminomutase. Members have a pair of CXXC motifs, and share homology to the amino-terminal region of a family of putative transcription factors for which the C-terminal is modeled by , a helix-turn-helix domain model. This family, however, is shorter and lacks the helix-turn-helix region. The function of this protein family is unknown, but a regulatory role in compatible solute biosynthesis is suggested by local genome context.
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Protein Domain
IPR009475
Name: Protein of unknown function DUF1096
Type: Family
Description: This family of unknown function consists of several proteins found in Caenorhabditis.
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Protein Domain
IPR009476
Name: Protein of unknown function DUF1097
Type: Family
Description: This family consists of several bacterial putative membrane proteins, including inner membrane protein YcdZ ( ) from Salmonella typhimurium.
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Protein Domain
IPR022455
Name: Methanol oxidation system protein MoxJ
Type: Family
Description: This entry represents a predicted periplasmic protein, called MoxJ or MxaJ and is required for methanol oxidation in Methylobacterium extorquens [ ].There are two differing opionions suggesting the role of this protein. The first is based on the homology of MoxJ, and suggests that it is the substrate-binding protein of an ABC transporter associated with methanol oxidation. The gene is also found in genomes with and only two or three genes away from a corresponding permease and ATP-binding cassette gene pair.The other opinion, is that MoxJ is an accessory factor or additional subunit of methanol dehydrogenase itself [ ]. Mutational studies show a dependence of MoxJ for the expression of the PQQ-dependent two-subunit methanol dehydrogenase (MxaF and MxaI) in Methylobacterium extorquens, possibly acting as a chaperone for enzyme assembly or a third subunit. A homologous N-terminal sequence was found in Acetobacter methanolicus as a 32Kd third subunit [].It is thought that MoxJ may in fact be both, a component of a periplasmic enzyme that converts methanol to formaldehyde and a component of an ABC transporter that delivers the resulting formaldehyde to the cells interior.
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Protein Domain
IPR010463
Name: Protein of unknown function DUF1057
Type: Family
Description: This entry consists of proteins of unknown function which have an alpha/beta hydrolase fold.
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Protein Domain
IPR009482
Name: Protein of unknown function DUF1102
Type: Family
Description: This family consists of proteins of unknown function.
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Protein Domain
IPR009484
Name: Protein of unknown function DUF1103
Type: Repeat
Description: This family consists of several repeats of around 30 residues in length which are found specifically in mature-parasite-infected erythrocyte surface antigen proteins from Plasmodium falciparum. This family often found in conjunction with .
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Protein Domain
IPR009488
Name: Protein of unknown function DUF1104
Type: Family
Description: This family consists of several hypothetical proteins of unknown function which appear to be found mainly in Helicobacter pylori. The structure of HP0721 protein consists of a bundle of four α-helices connected by loops and stabilised by hydrophobic interactions. It has been suggested that this protein might represent a novel H. pylori [ ].
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Protein Domain
IPR046402
Name: Fat storage-inducing transmembrane protein 1
Type: Family
Description: This family includes FIT1. Fat storage-inducing transmembrane protein family (FIT/FITM, also known as Acyl-coenzyme A diphosphatase ) plays an important role in lipid droplet accumulation. They are endoplasmic reticulum (ER) resident membrane proteins that induce lipid droplet accumulation in cell culture and when expressed in mouse liver [ ]; they hydrolyses fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate, with preference of unsaturated long-chain acyl-CoA substrates in the ER []. The ability to store fat in the form of cytoplasmic triglyceride droplets is conserved from yeast to humans, important for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis [, ]. The FIT family of proteins are not involved in triglyceride biosynthesis [].In mammals there are two FIT proteins, FIT1, which is muscle specific and FIT2, which is expressed in most other tissues [ , ]. Yeast has two FIT2 orthologues, called Scs3p and Yft2p but no FITM1. FIT1 and FIT2 proteins are six-transmembrane-domain containing proteins with both the N and C termini residing in the cytosol. FIT2 is the more ancient conserved homologue of the FIT family; this family of proteins do not share sequence similarity to known proteins or domains.
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Protein Domain
IPR046401
Name: Fat storage-inducing transmembrane protein 1/2
Type: Family
Description: This family includes FIT1 and FIT2 proteins. Fat storage-inducing transmembrane protein family (FIT/FITM, also known as Acyl-coenzyme A diphosphatase ) plays an important role in lipid droplet accumulation. They are endoplasmic reticulum (ER) resident membrane proteins that induce lipid droplet accumulation in cell culture and when expressed in mouse liver [ ]; they hydrolyses fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate, with preference of unsaturated long-chain acyl-CoA substrates in the ER []. The ability to store fat in the form of cytoplasmic triglyceride droplets is conserved from yeast to humans, important for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis [, ]. The FIT family of proteins are not involved in triglyceride biosynthesis [].In mammals there are two FIT proteins, FIT1, which is muscle specific and FIT2, which is expressed in most other tissues [ , ]. Yeast has two FIT2 orthologues, called Scs3p and Yft2p but no FITM1. FIT1 and FIT2 proteins are six-transmembrane-domain containing proteins with both the N and C termini residing in the cytosol. FIT2 is the more ancient conserved homologue of the FIT family; this family of proteins do not share sequence similarity to known proteins or domains.
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Protein Domain
IPR009490
Name: Protein of unknown function DUF1106
Type: Family
Description: This family consists of several hypothetical bacterial proteins found in Enterobacterales. The function of this family is unknown.
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Protein Domain
IPR009491
Name: Protein of unknown function DUF1107
Type: Family
Description: This family consists of several short, hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR046479
Name: Protein of unknown function DUF6800
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length and have conserved Arginine residues. This family may have an α-helical structure.
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Protein Domain
IPR046475
Name: Protein of unknown function DUF6796
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 220 and 250 amino acids in length.
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Protein Domain
IPR046474
Name: Protein of unknown function DUF6795
Type: Domain
Description: This domain, mainly found in bacteria, is functionally uncharacterised. This domain is approximately 100 amino acids in length and, based on structure prediction and overlaps with other families, belongs to the transthyretin superfamily. It is likely to have a seven stranded β-sandwich fold.
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Protein Domain
IPR022499
Name: ParB-related, ThiF-related cassette, protein A
Type: Family
Description: A novel genetic system characterised by six major proteins, included a ParB homologue and a ThiF homologue, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. This protein family is designated protein A.
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Protein Domain
IPR046498
Name: Protein of unknown function DUF6676
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in actinobacteria. Proteins in this family are typically between 172 and 197 amino acids in length.
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Protein Domain
IPR046495
Name: Protein of unknown function DUF6588
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 351 amino acids in length. There are several conserved Gly residues and two conserved motifs, AQ and GW.
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Protein Domain
IPR046494
Name: Protein of unknown function DUF6587
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in Proteobacteria. Proteins in this family are typically between 80 and 101 amino acids in length and contain four conserved cysteine residues at the C-terminal.
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Protein Domain
IPR046493
Name: Protein of unknown function DUF6586
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly in Proteobacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved motif NQ and a highly conserved Tryptophan residue.
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Protein Domain
IPR046492
Name: Protein of unknown function DUF6585
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 246 and 268 amino acids in length. There are seven highly conserved Gly residues.
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Protein Domain
IPR046491
Name: Protein of unknown function DUF6584
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly Actinobacteria and Firmicutes. Many members are thought to contain TPR regions. There are two conserved motifs, AxRL and LxxY.
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Protein Domain
IPR046490
Name: Protein of unknown function DUF6583
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly in Firmicutes. Proteins in this family are typically between 454 and 596 amino acids in length. There are two highly conserved residues, a Tyr and an Asp.
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Protein Domain
IPR046489
Name: Protein of unknown function DUF6582
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically around 100 amino acids in length. It includes two conserved motifs, FA and HVRxA.
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