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Search results 7401 to 7500 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR025133
Name: Poxvirus B22R protein N-terminal domain
Type: Domain
Description: This domain represents the highly conserved N-terminal region of poxvirus proteins from Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.
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Protein Domain
IPR039776
Name: Sister chromatid cohesion protein Pds5
Type: Family
Description: This entry includes sister chromatid cohesion protein Pds5 and its homologues. In budding yeasts, Pds5 is required for both sister chromatid cohesion and condensation [ ]. It forms the Pds5-Wapl complex that unloads cohesin from chromosomes [].
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Protein Domain
IPR039778
Name: Programmed cell death protein 4
Type: Family
Description: Programmed cell death protein 4 (PDCD4) binds to eukaryotic initiation factor 4A (eIF4A), inhibits translation initiation, and acts as a tumour suppressor. It contains two C-terminal MA3 domains that bind specifically to the eIF4A N-terminal domain (eIF4A-NTD) [ , , ].This entry also includes MRF1/2/3/4 from plants. They are involved in target of rapamycin (TOR)-egulated translation control, especially under energy-deficient conditions [ ].
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Protein Domain
IPR040755
Name: Interleukin receptor mimic protein A
Type: Family
Description: The E. coli interleukin [IL] receptor mimic protein A (IrmA), is a small (13kDa) Uropathogenic E. coli (UPEC) protein that was originally identified in a large reverse genetic screen as a broadly protective vaccine antigen. It has a fibronectin III (FNIII)-like fold that forms a domain-swapped dimer with structural mimicry to the binding domain of the IL-2 receptor (IL-2R), the IL-4 receptor (IL-4R) and, to a lesser extent, the IL-10 receptor (IL-10R). IrmA binds to all three cytokines, with the greatest affinity observed for IL-4. It is suggested that IrmA may contribute to manipulation of the innate immune response during UPEC infection [].
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Protein Domain
IPR025127
Name: Protein of unknown function DUF4054
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are found in bacteria and viruses.
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Protein Domain
IPR025128
Name: Poxvirus B22R protein C-terminal domain
Type: Domain
Description: This domain represents a highly conserved region towards the C terminus of poxvirus proteins from Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.
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Protein Domain
IPR040751
Name: S-layer protein SbsC, C-terminal domain
Type: Domain
Description: This domain is found in the crystalline bacterial cell-surface layer (S-layer) protein SbsC present in Geobacillus stearothermophilus. S-layers are a common feature of archaeal cell envelopes. SbsC is an oblique lattice forming protein. This domain, termed Domain 9, is located at the C-terminal region of SbsC. The C-terminal region comprises the self-assembly domain responsible for the formation of the crystalline array [ ].
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Protein Domain
IPR025126
Name: Protein of unknown function DUF4052
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR039762
Name: Nonsense-mediated mRNA decay protein Nmd2/UPF2
Type: Family
Description: This entry includes Nmd2 from yeasts and UPF2 from animals. They are involved in the nonsense-mediated mRNA decay (NMD) pathway [ , ]. In the human UPF complex (composed of UPF1/2/3), UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1 [].
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Protein Domain
IPR037107
Name: Putative outer membrane protein superfamily
Type: Homologous_superfamily
Description: This entry contains proteins that have no known function.
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Protein Domain
IPR025116
Name: Protein of unknown function DUF4035
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are found in bacteria and virus, and some are annotated as putative phage tail proteins.
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Protein Domain
IPR040740
Name: MglB-2, periplasmic binding protein domain
Type: Domain
Description: Treponema pallidum, the bacterium that causes syphilis, is an obligate human parasite. T. pallidum lacks the machinery for the de novo synthesis of many key nutrients therefore it acquires these nutrients from its human host. MglB-2 from T. pallidum has been shown to act as the ligand-binding element of an ABC transporter for D-glucose. The overall fold of MglB-2 resembles those of LBPs (Ligand-binding proteins sometimes called 'Periplasmic Binding Proteins') that serve as receptors for nutrients and cofactors in bacterial ABC transporters. Furthermore, structural analysis of MglB-2 found in Treponema pallidum shows it to be one of the founding member of a family of proteins related to the 'Type I' or 'Cluster B' LBPs [ ].
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Protein Domain
IPR025181
Name: Protein of unknown function DUF4108
Type: Family
Description: This family of putative proteins are found in Trichomonas vaginalis in large numbers. The function of this protein is unknown.
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Protein Domain
IPR025180
Name: Protein of unknown function DUF4107
Type: Family
Description: This family of putative proteins are found in Trichomonas vaginalis in large numbers. The function of this protein is unknown.
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Protein Domain
IPR025185
Name: Protein of unknown function DUF4120
Type: Family
Description: The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].
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Protein Domain
IPR025186
Name: Protein of unknown function DUF4119
Type: Family
Description: The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].
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Protein Domain
IPR025189
Name: Protein of unknown function DUF4121
Type: Family
Description: The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].
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Protein Domain
IPR025187
Name: Protein of unknown function DUF4112
Type: Family
Description: This uncharacterised protein family has several highly conserved GD sequence-motifs of unknown function.
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Protein Domain
IPR025170
Name: Protein of unknown function DUF3928
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are found in bacteria and are approximately 100 amino acids in length.
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Protein Domain
IPR025171
Name: Protein of unknown function DUF3929
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are approximately 70 amino acids in length and are found in bacteria.
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Protein Domain
IPR025174
Name: Protein of unknown function DUF3933
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are approximately 60 amino acids in length and are found in bacteria.
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Protein Domain
IPR025175
Name: Protein of unknown function DUF3934
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are approximately 40 amino acids in length and are found in bacteria. They contain two conserved sequence motifs: GTG and SKG.
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Protein Domain
IPR025172
Name: Protein of unknown function DUF3930
Type: Family
Description: This family consists of functionally uncharacterised bacterial proteins.
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Protein Domain
IPR025173
Name: Protein of unknown function DUF3932
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family are approximately 80 amino acids in length and are found in bacteria.
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Protein Domain
IPR025179
Name: Protein of unknown function DUF4106
Type: Family
Description: This family of proteins are found in large numbers in the Trichomonas vaginalis proteome. The function of this protein is unknown.
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Protein Domain
IPR025176
Name: Protein of unknown function DUF3935
Type: Family
Description: This family of bacterial proteins is functionally uncharacterised. Proteins in this family are approximately 90 amino acids in length and contain two conserved sequence motifs: FVF and LGV.
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Protein Domain
IPR025168
Name: Protein of unknown function DUF3925
Type: Family
Description: This family of bacterial proteins is functionally uncharacterised. Proteins in this family are approximately 70 amino acids in length.
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Protein Domain
IPR025165
Name: Protein of unknown function DUF4100
Type: Family
Description: This entry represents a family of uncharacterised proteins found in Physcomitrella.
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Protein Domain
IPR025169
Name: Protein of unknown function DUF3927
Type: Family
Description: This family of proteins is found in bacteria and viruses and is functionally uncharacterised. The proteins contain a conserved SVL sequence motif and a single completely conserved residue D that may be functionally important.
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Protein Domain
IPR040791
Name: Protein of unknown function DUF5555
Type: Family
Description: This is a family of unknown function found in mammals.
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Protein Domain
IPR013181
Name: Protein of unknown function DUF1719
Type: Family
Description: This is a group of proteins of unknown function from Gramineae (grasses).
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Protein Domain
IPR025190
Name: Protein of unknown function DUF4122
Type: Family
Description: The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].
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Protein Domain
IPR025191
Name: Protein of unknown function DUF4125
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR037172
Name: Flavivirus capsid protein C superfamily
Type: Homologous_superfamily
Description: The capsid protein C plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle [ , ].This superfamily represents the Flavivirus capsid protein C. Its core structure is composed of five helices with right-handed superhelix and swapped dimer with the two long C-terminal helices.
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Protein Domain
IPR013438
Name: Sporulation stage V, protein E
Type: Family
Description: Like FtsW, SpoVE proteins are encoded in a peptidoglycan operon context, but found only in endospore-forming bacteria such as Bacillus, Geobacillus and Oceanobacillus. In these genera they are part of a larger set of paralogs (not just the pair FtsW and RodA) and are required specifically for sporulation, not for viability.
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Protein Domain
IPR025421
Name: Protein of unknown function DUF4148
Type: Family
Description: This protein family is functionally uncharacterised.
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Protein Domain
IPR035553
Name: Cytokinesis protein 3, SH3 domain
Type: Domain
Description: Cytokinesis protein 3 (Cyk3) is a component of the actomyosin ring independent cytokinesis pathway in yeast. It interacts with Inn1 and facilitates its recruitment to the bud neck, thereby promoting cytokinesis [ , ]. Cyk3p contains an N-terminal SH3 domain and a C-terminal transglutaminase-like domain. This entry represents the SH3 domain of Cyk3. The Cyk3 SH3 domain binds to the C-terminal proline-rich region of Inn1 [ , ].
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Protein Domain
IPR025426
Name: Protein of unknown function DUF4305
Type: Family
Description: This family includes the Bacillus subtilis YdiK protein , which is functionally uncharacterised. This is not a homologue of Escherichia coli YdiK, which belongs to .
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Protein Domain
IPR025427
Name: Protein of unknown function DUF4160
Type: Family
Description: The function of these proteins is not known.
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Protein Domain
IPR013433
Name: Putative polyhydroxyalkanoic acid system protein
Type: Family
Description: Proteins in this entry are encoded by genes involved in either polyhydroxyalkanoic acid (PHA) biosynthesis or utilisation, including proteins at found at the surface of PHA granules. These proteins have so far been predominantly found in the Pseudomonadales, Xanthomonadales, and Vibrionales, all of which belong to the Gammaproteobacteria.
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Protein Domain
IPR025412
Name: Protein of unknown function DUF4304
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025415
Name: Protein of unknown function DUF4141
Type: Family
Description: This entry represents proteins of unknown function found primarily in Bacteroides species. The B. thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ].
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Protein Domain
IPR025401
Name: Protein of unknown function DUF4374
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025407
Name: Protein of unknown function DUF4133
Type: Family
Description: This entry represents proteins of unknown function found primarily in Bacteroides species. The B. thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ].
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Protein Domain
IPR025408
Name: Protein of unknown function DUF4134
Type: Domain
Description: This entry represents proteins of unknown function found primarily in Bacteroides species. The B. thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ].
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Protein Domain
IPR025409
Name: Protein of unknown function DUF4303
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR037449
Name: Formin-binding protein 1, F-BAR domain
Type: Domain
Description: Formin-binding protein 1 (FNBP1, also known as formin-binding protein 17) contains a N-terminal FER-CIP4 homology (FCH) domain and a C-terminal SH3 domain. It belongs to the CIP4 (Cdc42 interacting protein-4) subfamily of the F-BAR protein family. F-BAR proteins (F for FCH, Fer-CIP4 homology domain) are proteins with an extended CIP4-Fer domain. The F-BAR proteins have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis [ ]. FNBP1 was originally isolated as a molecule that binds to the proline-rich region of formin []. It induces tubular membrane invaginations and participates in endocytosis []. It interacts with sorting nexin, SNX2, and is linked to acute myelogeneous leukemia [].This entry represents the F-BAR domain of FNBP1. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [ ].
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Protein Domain
IPR025460
Name: Protein of unknown function DUF4280
Type: Family
Description: This family of proteins is functionally uncharacterised. There is a single completely conserved residue C that may be functionally important.
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Protein Domain
IPR025464
Name: Protein of unknown function DUF4315
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025462
Name: Protein of unknown function DUF4313
Type: Family
Description: The proteins in this family are functionally uncharacterised.
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Protein Domain
IPR025469
Name: Protein of unknown function DUF4320
Type: Family
Description: This family is functionally uncharacterised. There are two completely conserved residues (G and Y) that may be functionally important.
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Protein Domain
IPR025466
Name: Protein of unknown function DUF4317
Type: Family
Description: The proteins in this family are functionally uncharacterised. There is a single completely conserved residue P that may be functionally important.
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Protein Domain
IPR025467
Name: Protein of unknown function DUF4318
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family contain a single completely conserved residue F that may be functionally important.
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Protein Domain
IPR013478
Name: Methylamine dehydrogenase accessory protein MauD
Type: Family
Description: MauD appears critical to proper formation of the small subunit of methylamine dehydrogenase, which has both an unusual tryptophan tryptophylquinone cofactor and multiple disulphide bonds. MauD shares sequence similarity, including a CPxC motif, with a number of thiol:disulphide interchange proteins. In MauD mutants, the small subunit apparently does not form properly and is rapidly degraded [ ].
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Protein Domain
IPR037448
Name: Zwei Ig domain protein zig-8
Type: Family
Description: C. elegans Zig-8 is a immunoglobulin (Ig) domain-containing protein involved in maintaining neuronal soma and axon position [ ].
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Protein Domain
IPR025453
Name: Protein of unknown function DUF4309
Type: Family
Description: This family includes the Bacillus subtilis YjgB protein , which is functionally uncharacterised. This is not a homologue of Escherichia coli YjgB, . Expression of B. subtilis YjgB is regulated by the alternative transcription factor sigma-B [ ].
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Protein Domain
IPR025454
Name: Protein of unknown function DUF4275
Type: Family
Description: This protein family is functionally uncharacterised.
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Protein Domain
IPR025458
Name: Protein of unknown function DUF4278
Type: Family
Description: This family of proteins is functionally uncharacterised. There is a single completely conserved residue R that may be functionally important.
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Protein Domain
IPR025455
Name: Protein of unknown function DUF4276
Type: Family
Description: This family of proteins is functionally uncharacterised. There is a single completely conserved residue E that may be functionally important.
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Protein Domain
IPR025456
Name: Protein of unknown function DUF4310
Type: Family
Description: The proteins in this family are functionally uncharacterised.
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Protein Domain
IPR025459
Name: Protein of unknown function DUF4279
Type: Family
Description: This protein family is functionally uncharacterised.
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Protein Domain
IPR025443
Name: Protein of unknown function DUF4307
Type: Family
Description: This family of proteins is functionally uncharacterised Proteins in this family are typically between 132 and 153 amino acids in length and contain a single completely conserved residue C that may be functionally important.
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Protein Domain
IPR025441
Name: Protein of unknown function DUF4181
Type: Family
Description: This protein family is functionally uncharacterised.
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Protein Domain
IPR025447
Name: Protein of unknown function DUF4192
Type: Family
Description: This protein family is functionally uncharacterised.
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Protein Domain
IPR025445
Name: Protein of unknown function DUF4191
Type: Family
Description: This protein family is functionally uncharacterised.
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Protein Domain
IPR013455
Name: ABC transporter, D-xylose, ATP-binding protein
Type: Family
Description: ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.ABC transporters are involved in the export or import of a wide variety of substrates ranging from small ions to macromolecules. The major function of ABC import systems is to provide essential nutrients to bacteria. They are found only in prokaryotes and their four constitutive domains are usually encoded by independent polypeptides (two ABC proteins and two TMD proteins). Prokaryotic importers require additional extracytoplasmic binding proteins (one or more per systems) for function. In contrast, export systems are involved in the extrusion of noxious substances, the export of extracellular toxins and the targeting of membrane components. They are found in all living organisms and in general the TMD is fused to the ABC module in a variety of combinations. Some eukaryotic exporters encode the four domains on the same polypeptide chain [ ].The ABC module (approximately two hundred amino acid residues) is known to bind and hydrolyse ATP, thereby coupling transport to ATP hydrolysis in a large number of biological processes. The cassette is duplicated in several subfamilies. Its primary sequence is highly conserved, displaying a typical phosphate-binding loop: Walker A, and a magnesium binding site: Walker B. Besides these two regions, three other conserved motifs are present in the ABC cassette: the switch region which contains a histidine loop, postulated to polarise the attaching water molecule for hydrolysis, the signature conserved motif (LSGGQ) specific to the ABC transporter, and the Q-motif (between Walker A and the signature), which interacts with the gamma phosphate through a water bond. The Walker A, Walker B, Q-loop and switch region form the nucleotide binding site [, , ].The 3D structure of a monomeric ABC module adopts a stubby L-shape with two distinct arms. ArmI (mainly β-strand) contains Walker A and Walker B. The important residues for ATP hydrolysis and/or binding are located in the P-loop. The ATP-binding pocket is located at the extremity of armI. The perpendicular armII contains mostly the alpha helical subdomain with the signature motif. It only seems to be required for structural integrity of the ABC module. ArmII is in direct contact with the TMD. The hinge between armI and armII contains both the histidine loop and the Q-loop, making contact with the gamma phosphate of the ATP molecule. ATP hydrolysis leads to a conformational change that could facilitate ADP release. In the dimer the two ABC cassettes contact each other through hydrophobic interactions at the antiparallel β-sheet of armI by a two-fold axis [ , , , , , ].The ATP-Binding Cassette (ABC) superfamily forms one of the largest of all protein families with a diversity of physiological functions [ ]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [, ]. More than 50 subfamilies have been described based on a phylogenetic and functional classification [, , ].Several bacterial species use the enzymes xylose isomerase and xylulokinase for xylose utilisation. This entry represents the ATP-binding cassette (ABC) subunit of the known, or predicted, high-affinity xylose ABC transporter used for xylose import []. The genes encoding these proteins, which closely resemble other sugar transport ABC transporter genes, are typically found near xylose utilisation enzymes and regulatory proteins.
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Protein Domain
IPR025494
Name: Protein of unknown function DUF4385
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025492
Name: Protein of unknown function DUF4383
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025498
Name: Protein of unknown function DUF4389
Type: Family
Description: This family of proteins is functionally uncharacterised. There is a single completely conserved residue R that may be functionally important.
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Protein Domain
IPR025495
Name: Protein of unknown function DUF4386
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025496
Name: Protein of unknown function DUF4387
Type: Family
Description: This family of proteins is functionally uncharacterised. There is a conserved RSKN sequence motif.
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Protein Domain
IPR037474
Name: Sca1 complex scaffold protein ScaA
Type: Family
Description: ScaA/Sca1 is a component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (cAMP production) in Dictyostelium. The Sca1/RasGEF/PP2A complex controls the RasC-TORC2-PKB/PKBR1 pathway at the leading edge of chemotaxing cells. The Sca1 complex is recruited to the plasma membrane upon chemoattractant stimulation. ScaA acts as a molecular scaffold, bringing together GEFA, GEFH and PHR with PP2A [ ].
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Protein Domain
IPR025480
Name: Protein of unknown function DUF4330
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family have a single completely conserved residue G that may be functionally important.
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Protein Domain
IPR025488
Name: Protein of unknown function DUF4380
Type: Family
Description: This family of proteins is functionally uncharacterised. There are two completely conserved residues (G and E) that may be functionally important.
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Protein Domain
IPR025489
Name: Protein of unknown function (DUF4381
Type: Family
Description: This family of proteins is functionally uncharacterised.
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Protein Domain
IPR025470
Name: Protein of unknown function DUF4321
Type: Family
Description: The proteins in this family are functionally uncharacterised.
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Protein Domain
IPR025475
Name: Protein of unknown function DUF4326)
Type: Family
Description: This family of proteins is functionally uncharacterised. Proteins in this family have two completely conserved residues (P and C) that may be functionally important.
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Protein Domain
IPR025477
Name: Protein of unknown function DUF4327
Type: Family
Description: This family of bacterial proteins is functionally uncharacterised
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Protein Domain
IPR037497
Name: Protein PROTON GRADIENT REGULATION 5
Type: Family
Description: PGR5 is involved in the regulation of the cyclic electron flow around Photosystem I [ ]. Two types of electron transfer contribute to the proton concentration gradient across the thylakoid membrane: linear electron flow (LEF) and cyclic electron flow (CEF), which is divided into NDH- and PGR5-dependent pathways. The PGR5-PGRL1 complex mediates the second CET circuit, accepting electrons from ferrodoxin and reducing the plastoquinone pool. PGR5 is important to regulate and facilitate CET, and is essential for photoprotection in Arabidopsis [ , , ].
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Protein Domain
IPR003901
Name: Methyl-coenzyme M reductase, protein D
Type: Family
Description: Methyl-coenzyme M reductase (MCR) catalyses the reduction of methyl-coenzyme M (CH3-SCoM) and coenzyme B (HS-CoB) to methane and the corresponding heterosulphide CoM-S-S-CoB ( ), the final step in methane biosynthesis. This reaction proceeds under anaerobic conditions by methanogenic Archaea [ ], and requires a nickel-porphinoid prosthetic group, coenzyme F430, which is in the EPR-detectable Ni(I) oxidation state in the active enzyme. Studies on a catalytically inactive enzyme aerobically co-crystallized with coenzyme M displayed a fully occupied coenzyme M-binding site with no alternate conformations. The binding of coenzyme M appears to induce specific conformational changes that suggests a molecular mechanism by which the enzyme ensures that methyl-coenzyme M enters the substrate channel prior to coenzyme B, as required by the active-site geometry [].MCR is a hexamer composed of 2 alpha, 2 beta, and 2 gamma subunits with two identical nickel porphinoid active sites, which form two long active site channels with F430 embedded at the bottom [ , ]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits of MCR are separated by two open reading frames coding for two proteins C and D [ , ]. The function of proteins C and D is unknown. This entry represents protein D.
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Protein Domain
IPR027926
Name: Uncharacterised protein YqbF, N-terminal domain
Type: Domain
Description: This domain is found in N terminus of the uncharacterised protein YqbF from Bacillus subtilis. Its function is not known.
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Protein Domain
IPR027915
Name: Protein of unknown function DUF4452
Type: Family
Description: This fungal family has no known function. However, it is rich in paired, as CXXC, cysteines and histidines, but these do not fall in the conformation that might suggest zinc-binding.
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Protein Domain
IPR027913
Name: Protein of unknown function DUF4473
Type: Family
Description: This family is largely confined to Caenorhabditis proteins. Their function is not known. They have two well-conserved aspartate residues.
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Protein Domain
IPR027912
Name: Cilia- and flagella-associated protein 54
Type: Family
Description: CFAP54 is required for assembly and function of cilia and flagella [ ].
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Protein Domain
IPR027919
Name: Protein of unknown function DUF4568
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.
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Protein Domain
IPR027917
Name: Small integral membrane protein 20
Type: Family
Description: SMIM20, also known as MITRAC7, acts as a COX1-specific chaperone and is required for cytochrome c oxidase biogenesis [ ].
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Protein Domain
IPR027903
Name: Protein of unknown function DUF4566
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes and includes human protein C6orf62.
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Protein Domain
IPR027901
Name: Protein of unknown function DUF4541
Type: Family
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 100 and 163 amino acids in length. There is a conserved KLHRDDR sequence motif and a single completely conserved residue Y that may be functionally important. In humans, the gene is found in the chromosomal location, C5orf49.
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Protein Domain
IPR027908
Name: Protein of unknown function DUF4640
Type: Family
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 306 amino acids in length.
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Protein Domain
IPR027907
Name: BTB/POZ domain-containing protein 8, C-terminal
Type: Domain
Description: This domain is found in vertebrates. It is found at the C terminus of BTB/POZ domain-containing protein 8 (BTBD8, also known as AP2-interacting clathrin-endocytosis protein). BTBD8 is involved in clathrin-mediated endocytosis at the synapse and plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission [ ]. This domain contains a conserved ELET sequence motif and two completely conserved residues (S and E) that may be functionally important.
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Protein Domain
IPR027906
Name: Protein of unknown function DUF4567
Type: Family
Description: This family of proteins is functionally uncharacterised. It is found in some mammals.
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Protein Domain
IPR027905
Name: Cilia- and flagella-associated protein 95
Type: Family
Description: This family includes CFAP95, a microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating [ ].
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Protein Domain
IPR027909
Name: Protein of unknown function DUF4447
Type: Family
Description: This family of proteins is found in Shewanella species. Proteins in this family are approximately 170 amino acids in length.
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Protein Domain
IPR027960
Name: Protein of unknown function DUF4519
Type: Family
Description: Proteins in this family contain two conserved sequence motifs, KET and VLP, and a single completely conserved residue P that may be functionally important.
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Protein Domain
IPR003996
Name: RTX toxin-activating protein C, bacteria
Type: Family
Description: Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ ]. Four principal exotoxin secretion systems have been described. In the type II and IV secretion systems, toxins are first exported to the periplasm by way of a cleaved N-terminal signal sequence; a second set of proteins is used for extracellular transport (type II), or the C terminus of the exotoxin itself is used (type IV). Type III secretion involves at least 20 molecules that assemble into a needle; effector proteins are then translocated through this without need of a signal sequence. In the Type I system, a complete channel is formed through both membranes, and the secretion signal is carried on the C terminus of the exotoxin. The RTX (repeats in toxin) family of cytolytic toxins belong to the Type I secretion system, and are important virulence factors in Gram-negative bacteria. As well as the C-terminal signal sequence, several glycine-richrepeats are also found. These are essential for binding calcium, and are critical for the biological activity of the secreted toxins [ ]. All RTX toxin operons exist in the order rtxCABD, RtxA protein being the structuralcomponent of the exotoxin, both RtxB and D being required for its export from the bacterial cell; RtxC is an acyl-carrier-protein-dependent acyl- modification enzyme, required to convert RtxA to its active form [ ].Escherichia coli haemolysin (HlyA) is often quoted as the model for RTX toxins. Recent work on its relative rtxC gene product HlyC [] has revealed that it provides the acylation aspect for post-translational modification of two internal lysine residues in the HlyA protein. Other residues, including His23 and two conserved tyrosine residues, also appear to be important [].
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Protein Domain
IPR027965
Name: Protein of unknown function DUF4513
Type: Family
Description: This family of uncharacterised proteins is found in metazoans.
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Protein Domain
IPR027963
Name: Meiosis-specific coiled-coil domain-containing protein MEIOC
Type: Family
Description: In mice, MEIOC is required for meiosis completion in both male and female germ cells [ ]. It interacts with YTHDC2 and maintains an extended meiotic prophase I in mice []. In humans, it is encoded for on the chromosomal position C17orf104.
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Protein Domain
IPR027969
Name: Small membrane A-kinase anchor protein
Type: Family
Description: Small membrane A-kinase anchor protein (sm) AKAP binds to type I regulatory subunits of protein kinase A (PKA-RI) and anchors them to the plasma membrane. This way provides spatio-temporal specificity for cAMP-dependent protein kinase (PKA) signalling [ ]. Small membrane AKAP is localised at the plasma membrane via potential myristoylation/palmitoylation anchors.
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Protein Domain
IPR027967
Name: Protein of unknown function DUF4612
Type: Family
Description: This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 109 and 323 amino acids in length.
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Protein Domain
IPR001337
Name: Tobacco mosaic virus-like, coat protein
Type: Family
Description: This family contains virus coat proteins. Examples include those from Tobacco mosaic virus (TMV), Cucumber green mottle mosaic virus and Ribgrass mosaic virus (RMV).In order to establish infections, viruses must be delivered to the cells of potential hosts and must then engage in activities that enable their genomes to be expressed and replicated. With most viruses, the events that precede the onset of production of progeny virus particles are referred to as the early events and, in the case of positive-strand RNA viruses, they include the initial interaction with and entry of host cells and the release (uncoating) of the genome from the virus particles. The uncoating process in TMV may involve the bidirectional release of coat protein subunits from the viral RNA which may be mediated by cotranslational and coreplicational disassembly mechanisms [].The TMV particle is assembled from its constituent coat protein and RNA by a complex process. The protein forms an obligatory intermediate (a cylindrical disk composed of two layers of protein units), which recognises a specific RNA hairpin sequence. This mechanism simultaneously fulfils the physical requirement for nucleating the growth of the helical particle and the biological requirement for specific recognition of the viral DNA [ ].
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