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Search results 9001 to 9100 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
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Type Details Score
Protein Domain
IPR031958
Name: Protein of unknown function DUF4778
Type: Family
Description: This family of insect proteins is functionally uncharacterised. Proteins in this family are typically between 321 and 791 amino acids in length. There is a single completely conserved residue P that may be functionally important.
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Protein Domain
IPR018994
Name: Protein of unknown function DUF2002
Type: Family
Description: This entry represents a group of putative cytoplasmic proteins. The structure of these proteins form an antiparallel beta sheet and contain some alpha helical regions.
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Protein Domain
IPR018995
Name: RNA synthesis protein NSP10, coronavirus
Type: Domain
Description: Non-structural protein NSP10 is involved in RNA synthesis. It is synthesised as part of a replicase polyprotein, whose cleavage generates many non-structural proteins [ ]. NSP10 has a mixed α/β fold comprised of five α-helices contains, one 3(10)-helix, and three β-strands () and it is rich in cysteines, featuring two zinc fingers with Cx(2)-C-x(5)-H-x(6)-C and C-x(2)-C-x(7)-C-x-C motifs [ , ]. Twelve identical subunits assemble to form a unique spherical dodecameric architecture, which is proposed to be a functional form of the ExoN/MTase coactivator domainThe small NSP10 protein is among the more conserved coronavirus proteins and a critical cofactor for activation of multiple replicative enzymes. It interacts with NSP14 and NSP16 acting as a scaffolding protein and regulating their respective exonuclease (ExoN) and ribose-2'-O-MTase (2'-O-MTase) activities [ , ], mediating the stabilization of the SAM binding pockets of NSP16 and NSP14. When binding to the N-terminal of NSP14, NSP10 allows the ExoN active site to adopt a stably closed conformation, allowing efficient hydrolysis of dsRNA []. Efficient catalytic activity of NSP16 depends on heterodimerization with NSP10. The structure of the SARS-CoV-2 NSP10/NSP16 heterodimer revealed that it is extremely similar to that of its SARS-CoV-1 homologue [].One NSP10 residue, Tyr-96, is of particular interest. The aromatic nature of Tyr-96 plays a crucial role in the NSP10-NSP16 interaction and in the activation of the NSP16 2'-O-MTase activity as well as in the NSP10-NSP14 interaction. This residue is specific for SARS-CoV NSP10, and is a phenylalanine in other coronavirus homologues [ ].
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Protein Domain
IPR028366
Name: Phosphate transport system protein PhoU
Type: Family
Description: PhoU is a negative regulator in Pho regulon which plays a key role in phosphate homeostasis [ , ]. Members of the Pho regulon include alkaline phosphatase (AP), the PhoB-PhoR proteins and the PstSCAB and PhoU proteins. PhoU is encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions by a mechanism which is not fully understood. It has been proposed that PhoU may not only control the abundance of the PstSCAB2 transporter through the PhoBR two-component signaling pathway, but also control its activity []. PhoU is known to interact with PhoR and PstB, and it may be involved in the formation of a signaling complex at the cytoplasmic membrane that responds to environmental Pi levels [].
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Protein Domain
IPR016395
Name: Cytoplasmic envelopment protein 3, Simplexvirus
Type: Family
Description: Cytoplasmic envelopment protein 3 (UL11) is conserved throughout the herpesvirus family. It is a membrane-associated tegument protein that is incorporated into the HSV virion. UL11 and UL51, either singly or in combination, are involved in virion envelopment and/or egress. Both proteins are fatty acylated. UL11 is both acylated by myristoic and palmitoic acids while UL51 is mono-acylated by palmitoic acid [ , , , ].]. UL11 participates also in viral entry at the fusion step probably by regulating the core fusion machinery [ ]. It binds to either to gE or gI, promote the transport of virus particles in neuronal axons [].
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Protein Domain
IPR031991
Name: DNA repair protein Rev1, C-terminal
Type: Domain
Description: This entry represents the C-terminal domain of DNA repair protein Rev1, an enzyme which allows DNA synthesis to proceed even in the presence of DNA damage. Rev1 belongs to the Y-family of TLS polymerases. Rev1 possess a limited catalytic activity but it has a second and more important function which involved the recruitment and coordination of other Y-family TLS polymerases and the regulatory subunit Rev7 of the B-family polymerase pol. This interaction is mediated by its C-terminal domain which therefore serves as a scaffold that allows access of the Y-family polymerases to their cognate DNA lesions and the subsequent exchange to pol, which then extends the distorted DNA primer terminus opposite the lesion [, ]. This domain adopts a four-helix bundle that interacts with Rev7, Polkappa and Poleta. However, the Rev7-binding interface is distinct from the binding site of DNA polymerase eta or kappa [, ].
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Protein Domain
IPR031990
Name: Protein of unknown function DUF5066
Type: Family
Description: The function of DUF5066 is not clear.
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Protein Domain
IPR041319
Name: Protein of unknown function DUF5543
Type: Family
Description: This is a family of unknown function found in primates.
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Protein Domain
IPR043977
Name: Protein of unknown function DUF5759
Type: Family
Description: This is a family of uncharacterised proteins of unknown function found mostly in viruses.
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Protein Domain
IPR031999
Name: Pathogenicity island protein gp6, Staphylococcus
Type: Family
Description: Gp6, a Staphylococcus aureus pathogenicity island 1 protein, is a mobile genetic element that carries genes for several superantigen toxins. It is a dimeric protein produced from the pathogenicity island with a helix-loop-helix motif similar to that of bacteriophage scaffolding proteins. It is thought to determine the size of the capsids of distribution of the SAPI1 genome as it acts as an internal scaffolding protein during capsid size determination [ ].
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Protein Domain
IPR031998
Name: Protein of unknown function DUF5065
Type: Family
Description: This family is found in found in Bacillus species. The function is not known.
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Protein Domain
IPR028162
Name: Siroheme biosynthesis protein Met8, C-terminal
Type: Domain
Description: This entry represents the C-terminal domain of the siroheme biosynthesis protein Met8. In Saccharomyces cerevisiae, Met8 is a bifunctional dehydrogenase () and ferrochelatase ( ) [ ]. It catalyses the final two steps in the biosynthesis of sirohaem, involving a NAD(+)-dependent dehydrogenation of precorrin-2 to generate sirohydrochlorin followed by ferrochelation to yield sirohaem [].
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Protein Domain
IPR041139
Name: Major vault protein repeat domain
Type: Domain
Description: The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function [ ]. This entry corresponds to a repeated domain found in the amino terminal half of the major vault protein.
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Protein Domain
IPR037823
Name: Myotubularin-related protein 13, PH-GRAM domain
Type: Domain
Description: Myotubularin-related protein 13 (MTMR13), also known as SET-binding factor 2 (SBF2), belongs to the myotubularin family. It may function as a guanine nucleotide exchange factor (GEF) that activates Rab28 (a Rab GTPase) [ ]. Loss of MTMR13 leads to the Charcot-Marie-Tooth 4B (CMT4B) peripheral neuropathy, which is a recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system [, ].The family of myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, which contain inactivating substitutions in the phosphatase domain. MTMR13 is one of them. MTMR13 exists in cells independently as a homodimer, as well as in complex with a homodimer of MTMR2. Association with MTMR2 dramatically increases MTMR2 enzymatic activity [ ]. MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. This entry represents the PH-GRAM domain of MTMR13.
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Protein Domain
IPR031793
Name: Integrin-alpha FG-GAP repeat-containing protein 2
Type: Family
Description: Integrin-alpha FG-GAP repeat-containing protein 2 (ITFG2) may play a critical role in B cell differentiation and development of autoimmunity [ ]. It is a component of protein complex KICSTOR, also composed of KPTN, C12orf66 and SZT2, which is required for inhibition of mTORC1 as a result of amino acid or glucose deprivation [].
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Protein Domain
IPR043779
Name: Protein of unknown function DUF5721
Type: Family
Description: This is a family of unknown function, mostly found in Firmicutes.
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Protein Domain
IPR043776
Name: Protein of unknown function DUF5718
Type: Family
Description: This is a family of unknown function, mostly found in bacteria.
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Protein Domain
IPR043777
Name: Protein of unknown function DUF5719
Type: Family
Description: The function of DUF5719 is not clear.
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Protein Domain
IPR031796
Name: Protein of unknown function DUF5076
Type: Family
Description: This entry represents a group of uncharacterised bacterial proteins.
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Protein Domain
IPR028193
Name: Testis-expressed sequence 13 protein family
Type: Family
Description: The function of this family of proteins has not, as yet, been determined. However, members are thought to be encoded for by spermatogonially-expressed, germ-cell-specific genes [ ]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 177 and 384 amino acids in length. There are two conserved sequence motifs: FIN and LAL.
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Protein Domain
IPR028183
Name: Small integral membrane protein 4-like
Type: Family
Description: This entry represents a family of proteins from animals, including Small integral membrane protein 4 (Smim4) from humans. Smim4 is a mitochondrial ribosome-associated protein involved in the first steps of cytochrome c oxidase complex (complex IV) assembly [ ].
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Protein Domain
IPR028184
Name: Transcription cofactor vestigial-like protein 4
Type: Family
Description: Transcription cofactor vestigial-like protein 4 (Vgl-4) is a member of the Vgl family of TEF-1 (transcriptional enhancer factor-1) cofactors. Vgl-4 has two TDU motifs and is the only Vgl member expressed in the heart [ ]. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes [].
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Protein Domain
IPR041156
Name: Protein of unknown function DUF5533
Type: Family
Description: This is a family of unknown function found in chordata. Family members have multiple predicted transmembrane regions.
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Protein Domain
IPR018809
Name: Protein of unknown function DUF2406
Type: Family
Description: This entry represents a family of small proteins conserved in fungi. The function is not known.
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Protein Domain
IPR018807
Name: Cell wall protein YJL171C/Tos1, N-terminal
Type: Domain
Description: This entry represents a domain found in a group of fungal cell wall proteins, including Tos1 and YJL171C from budding yeasts. The function of this glycine-rich domain is unknown.
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Protein Domain
IPR018805
Name: Cell wall protein YJL171C/Tos1, C-terminal
Type: Domain
Description: This entry represents a domain found in a group of fungal cell wall proteins, including Tos1 and YJL171C from budding yeasts [ ]. They contain 5 highly conserved cysteines, two of which form a characteristic CGC sequence motif. Their function is not clear; this proteins are related to glycosyl hydrolases [].
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Protein Domain
IPR006836
Name: Protein of unknown function DUF612
Type: Family
Description: This family includes several uncharacterised proteins from Caenorhabditis elegans.
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Protein Domain
IPR018814
Name: Protein of unknown function DUF5427
Type: Family
Description: In Saccharomyces cerevisiae, maintenance of telomere capping protein 1 (Mtc1) may interact with ribosomes [ ] and is synthetically lethal with cdc13-1 [].
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Protein Domain
IPR043808
Name: Protein of unknown function DUF5790
Type: Family
Description: This is a family of proteins of unknown function found, predominantly, in Halobacteria.
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Protein Domain
IPR043809
Name: Protein of unknown function DUF5791
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043806
Name: Protein of unknown function DUF5870
Type: Family
Description: This entry represents uncharacterised proteins of unknown function found in Pandoraviruses.
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Protein Domain
IPR043804
Name: Protein of unknown function DUF5871
Type: Family
Description: This is a family of uncharacterised proteins of unknown function predominantly found in Phycodnaviridae.
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Protein Domain
IPR000256
Name: Influenza A virus NS1 protein
Type: Family
Description: NS1 is a homodimeric RNA-binding protein found in influenza virus that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA [ ].
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Protein Domain
IPR031820
Name: CRISPR-associated protein Csn2 subfamily St
Type: Family
Description: This is a family of Csn2 CRISPR-associated (Cas) proteins found in Firmicutes, largely Streptococcus and Enterococcus. CRISPR-associated (Cas) proteins are the main executioners of the process whereby prokaryotes acquire immunity against foreign genetic material. Cas allow short segments of this DNA, called spacer, to become incorporated into chromosomal loci as clustered regularly interspaced short palindromic repeats or CRISPRs; the resulting encoded RNAs are then processed into small fragments that guide the silencing of the invading genetic elements. Thus Cas are involved in the acquisition of new spacers.Proteins in this family are usually longer than the canonical Csn2 ( ) through the addition of a large C-terminal domain. The central domain present in both families appears to be a channel that selectively interacts with dsDNA [ ].
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Protein Domain
IPR018840
Name: Protein of unknown function DUF2441
Type: Family
Description: This is a family of highly conserved predicted proteins primarily found in Bacillus species. Structurally they form homo-dimers, but their function is unknown.
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Protein Domain
IPR018841
Name: Protein of unknown function DUF2442
Type: Family
Description: Several proteins in this family are annotated as being putative molybdopterin-guanine dinucleotide biosynthesis proteins, but this has not been confirmed. Members of this family also include proteins containing the N-terminal domain of the bacteria NE0471 protein. The function of these proteins is not known.
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Protein Domain
IPR017836
Name: Hopanoid biosynthesis associated protein HpnK
Type: Family
Description: This entry represents a subset of the YdjC-like family of uncharacterised proteins. The Acidithiobacillus ferrooxidans ATCC 23270 protein (AFE_0976) is encoded in the same locus as the genes for squalene-hopene cyclase (SHC, ) and other proteins associated with the biosynthesis of hopanoid natural products. Similarly, in Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) this protein (Reut_B4902) is encoded adjacent to the genes for HpnAB, IspH and HpnH ( ), although SHC itself is encoded elsewhere in the genome. Notably, this protein (here named HpnK) and three others form a conserved set (HpnIJKL) which occurs in a subset of all genomes containing the SHC enzyme. This relationship was discerned using the method of partial phylogenetic profiling [ ]. This group includes Zymomonas mobilis, the organism where the initial hopanoid biosynthesis locus was described consisting of the genes for HpnA-E and SHC (HpnF) []. Continuing past SHC are found genes encoding a phosphorylase enzyme (ZMO0873, i.e. HpnG, ) and a radical SAM enzyme (ZMO0874), HpnH. Although discontinuous in Z. mobilis, we continue the gene symbol sequence with HpnIJKL.
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Protein Domain
IPR006874
Name: Protein of unknown function DUF621
Type: Family
Description: This is a conserved region found in uncharacterised proteins from Caenorhabditis elegans, and is noted to have possible G-protein-coupled receptor-like activity.
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Protein Domain
IPR018850
Name: Mitochondrial escape protein 2, C-terminal
Type: Domain
Description: Mitochondrial escape protein 2 (also known as RNA12) plays a role in maintaining the mitochondrial genome and in controlling mtDNA escape [ , ]. It is also involved in the regulation of mtDNA nucleotide structure and number []. Additionally, this protein have a dispensable role in the early maturation of pre-rRNA []. This domain is C-terminal to the RRM domain and includes a P-loop motif suggesting this domain may bind to NTP.
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Protein Domain
IPR031816
Name: Protein of unknown function DUF5073
Type: Family
Description: This family of unknown function consists of membrane proteins from Mycobacterium [ ].
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Protein Domain
IPR031815
Name: Protein of unknown function DUF5074
Type: Family
Description: This family of proteins from Bacteroidetes has a PKD domain at the N terminus. Several members are annotated as putative quinonprotein alcohol dehydrogenase-like proteins but this could not be confirmed.
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Protein Domain
IPR018858
Name: Protein of unknown function DUF2458
Type: Family
Description: This entry represents a family of uncharacterised proteins.
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Protein Domain
IPR034655
Name: Alginate biosynthesis protein AlgX, N-terminal
Type: Domain
Description: The alginate biosynthesis protein AlgX appears to be directly involved in the O-acetylation of alginate, an exopolysaccharide that is associated with the formation of persistent biofilms, such as those by mucoid strains of Pseudomonas aeruginosa that affect patients suffering from cystic fibrosis [ , ]. This N-terminal catalytic domain resembles SGNH hydrolases, though with a permuted topology. The active site matches that of the SGNH hydrolases, is well conserved, and has been verified experimentally [, ]. AlgX also contains a C-terminal carbohydrate binding domain.
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Protein Domain
IPR018853
Name: Protein of unknown function DUF2457
Type: Family
Description: This entry represents a family of uncharacterised proteins.
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Protein Domain
IPR018852
Name: Protein of unknown function DUF2456
Type: Family
Description: This entry represents a family of uncharacterised proteins.
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Protein Domain
IPR031806
Name: Protein of unknown function DUF4744
Type: Family
Description: This family of proteins from Drosophila is functionally uncharacterised. Proteins in this family are typically between 81 and 415 amino acids in length.
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Protein Domain
IPR006851
Name: Protein of unknown function DUF613
Type: Family
Description: This is a family of chloroplast proteins of unknown function. Some members have two copies of the conserved region.
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Protein Domain
IPR006859
Name: Influenza B matrix protein 2
Type: Family
Description: BM2 is integral membrane protein that displays H(+) ion channel activity that plays critical roles in production of infectious virus. It is synthesised in the late phase of infection and incorporated into the virion. The cytoplasmic domain of the BM2 protein is required for firm association of the M1 protein with lipid membranes, vRNP complex incorporation into virions, and virion morphology [ ].
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Protein Domain
IPR006858
Name: Chicken anaemia virus VP-3 protein
Type: Family
Description: Chicken anaemia virus (CAV) is a circovirus which can cause severe depletion of some cell types, such as lymphocytes, by the induction of apoptosis [ ]. Studies indicate that expression of the viral VP3 protein, also known as apoptin, is sufficient to induce apoptosis in susceptible cells and to produce the doughnut-shaped apoptosis body formations observed in cells during CAV infections. This protein induces apoptosis in tumor cells and transformed cells, but is incapable of inducing apoptosis in normal cells unless tranforming signals are supplied which induce its phosphorylation. Cell death occurs in a p53- and Bcl-2-independent manner []. Apoptin contains putative nuclear localisation and nuclear export domains, and has a positively charged C terminus which is thought to allow direct interaction with nucleic acids. Localisation to the nucleus appears to be necessary for apoptosis, but is not sufficient on its own. The biologically active form of the protein appears to be large complexes of 30-40 molecules which form distinct superstructures upon DNA binding. A number of cellular factors including Nmi, and several death domain superfamily proteins, have been shown to interact apoptin. It has been suggested that in the nucleus, it this binding of phosphorylated apoptin to DNA and other factors which starts the apoptotic machinery, triggering cell death.
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Protein Domain
IPR018830
Name: Protein of unknown function DUF2434
Type: Family
Description: This entry represents a family of proteins conserved in fungi. Their function is not known.
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Protein Domain
IPR031860
Name: Protein of unknown function DUF4754
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
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Protein Domain
IPR043849
Name: Protein of unknown function DUF5859
Type: Family
Description: This family of proteins represents uncharacterised proteins of unknown function predominantly found in Mimiviridae.
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Protein Domain
IPR043846
Name: Protein of unknown function DUF5863
Type: Family
Description: This entry represents proteins of unknown function predominantly found in Betabaculoviruses.
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Protein Domain
IPR043845
Name: Protein of unknown function DUF5864
Type: Family
Description: This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
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Protein Domain
IPR004245
Name: Protein of unknown function DUF229
Type: Family
Description: Members of this family are uncharacterised with a long conserved region that may contain several domains.
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Protein Domain
IPR043840
Name: Protein of unknown function DUF5868
Type: Family
Description: This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
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Protein Domain
IPR031864
Name: Protein of unknown function DUF4756
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.
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Protein Domain
IPR031863
Name: Protein of unknown function DUF4755
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.
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Protein Domain
IPR043835
Name: Protein of unknown function DUF5811
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043833
Name: Protein of unknown function DUF5810
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043832
Name: Protein of unknown function DUF5809
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043830
Name: Protein of unknown function DUF5807
Type: Family
Description: This is a family of proteins of unknown function found in Halobacteria.
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Protein Domain
IPR018894
Name: Protein of unknown function DUF2471
Type: Family
Description: The function of this family is unknown. Members all come from Burkholderia spp. A number of proteins in this entry, including , are annotated as serine/threonine-protein kinases.
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Protein Domain
IPR031858
Name: Protein of unknown function DUF4752
Type: Family
Description: This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 90 and 105 amino acids in length. There is a conserved GLA sequence motif.
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Protein Domain
IPR031855
Name: Protein of unknown function DUF4751
Type: Family
Description: This family of uncharacterised proteins is found in bacteria.
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Protein Domain
IPR016239
Name: Ribosomal protein S6 kinase II
Type: Family
Description: This entry represents ribosomal protein S6 kinase II [ ]. This enzyme acts as a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). It plays an essential role in the control of RELA transcriptional activity in response to TNF. It directly represses transcription via phosphorylation of Ser-1 of histone H2A. It phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. It mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). It requires magnesium ions as a cofactor.
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Protein Domain
IPR018897
Name: Plasmid conjugative transfer protein PilI
Type: Family
Description: The thin pilus of plasmid R64 belongs to the type IV family and is required for liquid matings. PilI is one of 14 genes that have been identified as being involved in biogenesis of the R64 thin pilus [ ].
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Protein Domain
IPR018895
Name: Protein of unknown function DUF2474
Type: Family
Description: This family of short proteins has no known function.
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Protein Domain
IPR031851
Name: Protein of unknown function DUF4750
Type: Family
Description: This family of uncharacterised proteins includes proteins described as small integral membrane protein 13. This family of proteins is found in eukaryotes. There are two completely conserved W residues that may be functionally important.
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Protein Domain
IPR043828
Name: Protein of unknown function DUF5805
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043829
Name: Protein of unknown function DUF5806
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria and Methanomicrobia.
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Protein Domain
IPR043826
Name: Protein of unknown function DUF5803
Type: Family
Description: DUF5803 is a family of unknown function predominantly found in Halobacteria and Methanomicrobia.
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Protein Domain
IPR043827
Name: Protein of unknown function DUF5804
Type: Family
Description: This is a family of unknown function predominantly found in Halobacteria and Methanomicrobia.
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Protein Domain
IPR043825
Name: Protein of unknown function DUF5802
Type: Family
Description: DUF5802 is a family of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043823
Name: Protein of unknown function DUF5800
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043821
Name: Protein of unknown function DUF5799
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR031840
Name: Protein male-specific lethal-1, dimerisation domain
Type: Domain
Description: This entry represents the short coiled dimerisation domain of higher eukaryotic MSL1, part of the MSL or Male-Specific Lethal complex. This complex regulates the dosage compensation of the male X chromosome in Drosophila and other eukaryotes. The structure of the MSL1/MSL2 core shows that two MSL2 subunits bind to a dimer formed by two molecules of MSL1. MSL1 is a substrate for MSL2 E3 ubiquitin ligase activity [ ].
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Protein Domain
IPR004230
Name: DNA mismatch repair protein MutH
Type: Family
Description: MutS, MutL and MutH are the three essential proteins for initiation of methyl-directed DNA mismatch repair to correct mistakes made during DNA replication in Escherichia coli. MutH cleaves a newly synthesized and unmethylated daughter strand 5' to the sequence d(GATC) in a hemi-methylated duplex. Activation of MutH requires the recognition of a DNA mismatch by MutS and MutL [ ].
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Protein Domain
IPR006893
Name: Citrus tristeza virus P23 protein
Type: Family
Description: This family of proteins contains p23 from the citrus tristeza virus, which is a member of the Closteroviridae. CTV produces more positive than negative RNA strands, and p23 controls this asymmetrical RNA accumulation. Amino acids 42-180 are essential for function and are thought to contain RNA-binding and zinc finger domains [ ].
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Protein Domain
IPR006891
Name: Type III secretion protein EspF
Type: Repeat
Description: Enteropathogenic Escherichia coli O127:H6 attaches to the intestinal mucosa through actin pedestals that are created after it has injected the Type III secretion protein EspF (E. coli secreted protein F-like protein from prophage U) into the cells. EspF recruits the actin machinery by activating the WASP (Wiscott-Aldrich syndrome protein) family of actin nucleating factors [ ]. Subsequent cell-death (apoptosis) is caused by EspF being targeted to the mitochondria as a consequence of its mitochondrial targeting sequence. Import into mitochondria leads to a loss of membrane potential, leakage of cytochrome c and activation of the apoptotic caspase cascade. Mutation of leucine to glutamic at position 16 of EspF (L16E) resulted in the failure of EspF import into mitochondria; mitochondrial membrane potential was not affected and cell death abolished. This suggests that the targeting of EspF to mitochondria is essential for bacterial pathogenesis and apoptosis [, ].
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Protein Domain
IPR043815
Name: Protein of unknown function DUF5797
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043816
Name: Protein of unknown function DUF5798
Type: Family
Description: DUF5798 is a family of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043813
Name: Protein of unknown function DUF5795
Type: Family
Description: Proteins in this family are predominantly found in Halobacteria.
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Protein Domain
IPR004239
Name: Protein of unknown function DUF228
Type: Family
Description: This group comprises proteins of unknown function from Borrelia burgdorferi, the causitive organism of Lyme disease.
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Protein Domain
IPR043814
Name: Protein of unknown function DUF5796
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043811
Name: Protein of unknown function DUF5793
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043812
Name: Protein of unknown function DUF5794
Type: Family
Description: This is a family of proteins of unknown function predominantly found in Halobacteria.
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Protein Domain
IPR043810
Name: Protein of unknown function DUF5792
Type: Family
Description: Proteins in this family can be found in prasinoviruses.
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Protein Domain
IPR031839
Name: Protein of unknown function DUF5070
Type: Family
Description: This protein family is specific to Chlamydia. Members of this group had initially been related to a divalent cation transcription repressor [ ]. However, protein CT296 from Chlamydia trachomatis , which show structural features typical of non-heme Fe(II) 2-oxoglutarate-dependent enzymes, contradicts this statement []. The specific function of these proteins is not known.
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Protein Domain
IPR031833
Name: Protein of unknown function DUF4748
Type: Family
Description: This family of proteins is functionally uncharacterised and is found in eukaryotes.
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Protein Domain
IPR031832
Name: Protein of unknown function DUF4747
Type: Family
Description: This family of proteins is found in bacteria. Proteins in this family are typically between 263 and 305 amino acids in length.
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Protein Domain
IPR043888
Name: Protein of unknown function DUF5844
Type: Family
Description: This is a family of uncharacterised proteins found in Iridoviridae. Its function is unknown.
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Protein Domain
IPR043889
Name: Protein of unknown function DUF5843
Type: Family
Description: This is a family of uncharacterised proteins predominantly found in viruses.
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Protein Domain
IPR043886
Name: Protein of unknown function DUF5846
Type: Family
Description: This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
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Protein Domain
IPR043887
Name: Protein of unknown function DUF5845
Type: Family
Description: This family of uncharacterised proteins of unknown function is mainly found in Mimiviridae and Marseilleviridae.
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Protein Domain
IPR043885
Name: Protein of unknown function DUF5847
Type: Family
Description: This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
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Protein Domain
IPR043882
Name: Protein of unknown function DUF5850
Type: Family
Description: This is a family of uncharacterised proteins found in Iridoviridae. These proteins possess a conserved motif towards the C-terminal, containing a central RGD sequence, which suggests that these viral proteins may bind to integrins.
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Protein Domain
IPR043883
Name: Protein of unknown function DUF5849
Type: Family
Description: This is a family of uncharacterised proteins of unknown function found in pandoraviruses.
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Protein Domain
IPR043880
Name: Protein of unknown function DUF5852
Type: Family
Description: This is a family of uncharacterised proteins of unknown function found in ranaviruses.
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Protein Domain
IPR043881
Name: Protein of unknown function DUF5851
Type: Family
Description: This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
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