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Search results 9201 to 9300 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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0.032s

Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR019658
Name: Protein of unknown function DUF2515
Type: Family
Description: This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.
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Protein Domain
IPR019659
Name: Protein of unknown function DUF2514
Type: Family
Description: This protein family is conserved in bacteria and some viruses. The function is not known. This entry includes the protein gp55 from Enterobacteria phage N15.
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Protein Domain
IPR019657
Name: Late competence development protein ComFB
Type: Family
Description: Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use components of extracellular filaments called type 4 pili to create pores in their membranes and pull DNA through the pores into the cytoplasm. This process, including the development of competence and the expression of the uptake machinery, is regulated in response to cell-cell signalling and/or nutritional conditions [ ].The development of genetic competence in Bacillus subtilis is a highly regulated adaptive response to stationary-phase stress. For competence to develop, the transcriptional regulator, ComK, must be activated. ComK is required for the expression of genes encoding proteins that function in DNA uptake. In log-phase cultures, ComK is inactive in a complex with MecA and ClpC. The comS gene is induced in response to high culture cell density and nutritional stress and its product functions to release active ComK from the complex. ComK then stimulates the transcription initiation of its own gene as well as that of the late competence operons [ ].The comF locus has three open reading frames and is driven by a single sigma A-like promoter in front of comFORF1. It is dependent on early regulatory competence genes and is only expressed in competence medium. ComFORF1 is similar to an extensive family of ATP-dependent RNA/DNA helicases with closer similarity to the DEAD protein subfamily and to the PriA protein in Escherichia coli. ComFORF1 late gene product plays an essential role during the binding and uptake events involved in B. subtilis transformation [ ]. ComFB is the second protein encoded within the late competence locus ComF []. The function of ComFB within late competence development is not known.
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Protein Domain
IPR019662
Name: Protein of unknown function DUF2516
Type: Family
Description: This entry represents a conserved protein in Actinobacteria. The function is not known.
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Protein Domain
IPR032627
Name: Protein of unknown function DUF4876
Type: Family
Description: This entry represents a group of uncharacterised proteins from bacteria. Proteins in this entry contain a conserved NNS sequence motif.
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Protein Domain
IPR019669
Name: Uncharacterised bacterial stress protein YodD
Type: Family
Description: This entry represents the uncharacterised protein family YodD which appear to be restricted to Enterobacteriaceae, and are thought to be stress-related proteins [ ].
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Protein Domain
IPR032624
Name: Protein of unknown function DUF4879
Type: Family
Description: This entry represent a family of bacterial proteins with phage origin, exemplified by protein SPBc2p013 from Bacillus phage SPBc2. This entry also includes SPbeta prophage-derived uncharacterized protein YolA from Bacillus subtilis. The function of this family is not clear.
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Protein Domain
IPR017004
Name: Uncharacterised conserved protein UCP032676, PqqC
Type: Family
Description: This group represents an uncharacterised protein with PqqC domain.
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Protein Domain
IPR032621
Name: Protein of unknown function DUF4881
Type: Family
Description: This small family consists of several uncharacterised proteins around 200 residues in length and is mainly found in Desulfovibrio species. The function of this protein is unknown.
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Protein Domain
IPR032620
Name: Protein of unknown function DUF4882
Type: Family
Description: This entry represents a family of several uncharacterised proteins around 325 residues in length and is mainly found in various Acinetobacter species. The function of this family is unknown.
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Protein Domain
IPR032619
Name: Protein of unknown function DUF4883
Type: Family
Description: This family consists of several uncharacterised proteins around 160 residues in length and is mainly found in Clostridium species. The function of this family is unknown.
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Protein Domain
IPR032618
Name: Protein of unknown function DUF4884
Type: Family
Description: This family consists of several uncharacterised proteins around 90 residues in length and is mainly found in bacteria. The function of this family is unknown.
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Protein Domain
IPR032617
Name: Protein of unknown function DUF4885
Type: Family
Description: This family consists of several uncharacterised proteins around 390 residues in length and is mainly found in Bacillus species. The function of this family is not clear.
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Protein Domain
IPR019638
Name: Protein of unknown function DUF2502
Type: Family
Description: This entry represents proteins mainly found in Gammaproteobacteria. The function is not known.
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Protein Domain
IPR019639
Name: Protein of unknown function DUF2505
Type: Family
Description: This entry represents proteins found Actinobacteria and Proteobacteria. The function is not known.
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Protein Domain
IPR032615
Name: Protein of unknown function DUF4887
Type: Family
Description: This family consists of uncharacterised proteins around 210 residues in length and is mainly found in various Staphylococcus species. The function of this family is unknown.
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Protein Domain
IPR032614
Name: Protein of unknown function DUF4888
Type: Family
Description: This family consists of uncharacterised proteins around 190 residues in length and is mainly found in various Staphylococcus species. The function of this family is unknown.
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Protein Domain
IPR019637
Name: Protein of unknown function DUF2501
Type: Family
Description: This entry represents proteins that are found in Proteobacteria. Several are annotated as being YjjA or YjjA-like, but this protein is uncharacterised.
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Protein Domain
IPR032613
Name: Protein of unknown function DUF4889
Type: Family
Description: This family consists of uncharacterised proteins around 110 residues in length and is mainly found in various Staphylococcus species. The function of this family is unknown.
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Protein Domain
IPR032612
Name: Protein of unknown function DUF4890
Type: Family
Description: This family consists of uncharacterised proteins around 200 residues in length and is mainly found in various Bacteroides and Prevotella species. The function of this family is unknown.
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Protein Domain
IPR019635
Name: Protein of unknown function DUF2500
Type: Family
Description: This entry represents a group of proteins that is largely confined to the Gammaproteobacteria. The function is not known.
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Protein Domain
IPR032611
Name: Protein of unknown function DUF4891
Type: Family
Description: This family consists of uncharacterised proteins around 140 residues in length and is mainly found in various Bacteroides species. The function of this family is unknown.
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Protein Domain
IPR019632
Name: Protein of unknown function DUF2497
Type: Family
Description: Members of this family belong to the Alphaproteobacteria. The function of the family is not known.
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Protein Domain
IPR019633
Name: Protein of unknown function DUF2498
Type: Family
Description: This entry represents proteins found in gammaproteobacteria, including YciN from Escherichia coli. Their function is not known.
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Protein Domain
IPR019642
Name: Protein of unknown function DUF2507
Type: Family
Description: This entry represents a family of conserved proteins found primarily in Firmicutes. The function is not known.
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Protein Domain
IPR032609
Name: Protein of unknown function DUF4893
Type: Family
Description: This family consists of uncharacterised proteins around 200 residues in length and is mainly found in Proteobacteria. The function of this family is unknown.
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Protein Domain
IPR032608
Name: Protein of unknown function DUF4892
Type: Family
Description: This family consists of uncharacterised proteins mainly found in Proteobacteria. This entry includes PA1624, an hypothetical periplasmic protein from Pseudomonas aeruginosa that may be a potential drug target [ ].
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Protein Domain
IPR032607
Name: Protein of unknown function DUF4894
Type: Family
Description: This entry represents a family of uncharacterised proteins around 180 residues in length and found in Thermotogae. The function of this family is unknown.
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Protein Domain
IPR032606
Name: Protein of unknown function DUF4895
Type: Family
Description: This entry represents a family of uncharacterised proteins around 250 residues in length and found in various Thermotoga species. The function of this family is unknown.
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Protein Domain
IPR019649
Name: Protein of unknown function DUF2512
Type: Family
Description: Proteins in this entry are predicted to be integral membrane proteins, and many of them are annotated as being YndM protein. They are all found in Firmicutes. The true function is not known.
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Protein Domain
IPR032604
Name: Protein of unknown function DUF4897
Type: Family
Description: This is a small family of uncharacterised proteins around 200 residues in length found in Thermotogae and Halobacteria. The function of this family is unknown.
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Protein Domain
IPR019647
Name: PhoP regulatory network protein YrbL
Type: Family
Description: This entry represents proteins that are activated by the protein PhoP. PhoP controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multi-component loop in Salmonella sp., where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner [ ].
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Protein Domain
IPR032603
Name: Protein of unknown function DUF4898
Type: Family
Description: This entry represents a family of uncharacterised proteins around 100 residues in length and found in Sulfolobaceae. The function of this family is unknown.
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Protein Domain
IPR032602
Name: Protein of unknown function DUF4899
Type: Family
Description: A small family of uncharacterised proteins around 340 residues in length and found in bacteria. The function of this family is unknown.
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Protein Domain
IPR032601
Name: Protein of unknown function DUF4900
Type: Family
Description: This family consists of uncharacterised proteins around 600 residues in length and is found in bacteria. The function of this family is unknown.
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Protein Domain
IPR019644
Name: Protein of unknown function DUF2508
Type: Family
Description: This entry represents a protein family of unknown function that is conserved in the firmicutes.
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Protein Domain
IPR007480
Name: Protein of unknown function DUF529
Type: Repeat
Description: This entry represents a repeated region found in several Theileria parva proteins.The repeat is normally about 70 residues long and contains a conserved aromatic residue in the middle.
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Protein Domain
IPR011983
Name: 4-hydroxyphenylacetate catabolism regulatory protein HpaA
Type: Family
Description: This putative transcriptional regulator, which contains both the substrate-binding, dimerisation domain and the helix-turn-helix DNA-binding domain of the AraC famil, is located proximal to genes of the 4-hydroxyphenylacetate catabolism pathway [ ].
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Protein Domain
IPR019469
Name: Protein of unknown function DUF2443
Type: Family
Description: This entry represents a small group of highly conserved proteins from bacteria, in particular Helicobacter species. The structure is a bundle of alpha helices. The function is not known.
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Protein Domain
IPR032422
Name: Huntingtin-interacting protein 1, clathrin-binding domain
Type: Domain
Description: This entry represents the coiled-coil region of Huntingtin-interacting protein 1 (HIP1). It carries a highly conserved HADLLRKN sequence motif at its N terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. This binding then stimulates clathrin lattice assembly. HIP1 is an obligate binding partner for Huntingtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Huntington's disease [ ]. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding [].
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Protein Domain
IPR007451
Name: High frequency lysogenization protein HflD
Type: Family
Description: When bacteriophage lambda infects to the Escherichia coli cell, it undergoes either lytic growth or lysogenization. The lambda CII protein is a key determinant in the lysis-lysogeny decision. Escherichia coli HflD is a factor that may sequesters CII from the target promoters and recruits it to the membrane where the FtsH protease is localized [ ].
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Protein Domain
IPR007458
Name: Protein of unknown function DUF496
Type: Family
Description: Members of this family are uncharacterised proteins.
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Protein Domain
IPR019431
Name: Protein of unknown function DUF2417
Type: Family
Description: This entry represents a family of fungal proteins with no known function. In some cases these proteins also contain an alpha/beta hydrolase fold ( ).
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Protein Domain
IPR007465
Name: Protein of unknown function DUF508
Type: Family
Description: This is a family of uncharacterised proteins from Caenorhabditis elegans.
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Protein Domain
IPR007463
Name: Protein of unknown function DUF507
Type: Family
Description: This entry represents a bacterial protein of unknown function.
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Protein Domain
IPR020497
Name: Protein of unknown function DUF5440
Type: Family
Description: This is a family of unknown function found in Proteobacteria.
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Protein Domain
IPR032479
Name: Protein of unknown function DUF5058
Type: Family
Description: This family consists of uncharacteried proteins around 250 residues in length and is mainly found in various Firmicutes species. The function of this family is unknown.
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Protein Domain
IPR020484
Name: Protein of unknown function DUF5503
Type: Family
Description: This is a family of unknown function found in Enterobacteriaceae. This family includes uncharacterised protein YedM.
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Protein Domain
IPR032440
Name: 40S ribosomal protein S11, N-terminal
Type: Domain
Description: This short N-terminal region is found in a number of eukaryotic ribosomal subunit 11 proteins [ ].
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Protein Domain
IPR032494
Name: Lambda phage tail tube protein
Type: Family
Description: This family represents the phage-tail-tube protein from a set of Siphoviridae from Gammaproteobacteria. Tail tube proteins (TTPs) polymerise with the assistance of the Tail-tip complex, a tape measure protein and two chaperones. Infectivity of host is delivered through the tube [ ].
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Protein Domain
IPR032493
Name: Phage tail tube protein family
Type: Family
Description: This is a small family of Siphoviridae phage tail tube proteins. The tube protein polymerises to form the shaft through which the infecting DNA passes into the host [ ].
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Protein Domain
IPR032484
Name: Protein of unknown function DUF5052
Type: Family
Description: This family consists of uncharacterised proteins around 200 residues in length and is mainly found in various Firmicutes species. The function of this family is unknown.
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Protein Domain
IPR032483
Name: Protein of unknown function DUF5053
Type: Family
Description: This family consists of uncharacterised proteins mainly from Bacteroides and Prevotella spp. The function of this family is unknown.
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Protein Domain
IPR032482
Name: Protein of unknown function DUF5054
Type: Family
Description: This family consists of Glycosyl hydrolase family 38 proteins around 700 residues in length. The function of this family is unknown.
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Protein Domain
IPR032481
Name: Protein of unknown function DUF5055
Type: Family
Description: This family consists of several uncharacterised proteins around 100 residues in length and is mainly found in butyrate-producing bacteria. This family also includes sequences from phages. The function of this family is unknown.
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Protein Domain
IPR032488
Name: Protein of unknown function DUF5049
Type: Family
Description: This family consists of some uncharacterised proteins around 60 residues in length. The function of this family is unknown.
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Protein Domain
IPR007511
Name: Protein of unknown function DUF501
Type: Family
Description: This is a family of uncharacterised bacterial proteins.
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Protein Domain
IPR007501
Name: Protein of unknown function DUF531
Type: Family
Description: This is a family of hypothetical archaeal proteins.
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Protein Domain
IPR007509
Name: Protein of unknown function DUF515
Type: Family
Description: This is a family of hypothetical archaeal proteins.
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Protein Domain
IPR007556
Name: Protein of unknown function DUF483
Type: Family
Description: This is a family of uncharacterised prokaryotic proteins.
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Protein Domain
IPR007555
Name: Protein of unknown function DUF499
Type: Family
Description: This is a family of uncharacterised hypothetical prokaryotic proteins.
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Protein Domain
IPR019536
Name: Harmonin-binding protein USHBP1, PDZ-binding domain
Type: Domain
Description: The entry represents the PDZ-binding domain of Harmonin-binding protein USHBP1 (also known as MCC2, mutated in colon cancer-2). USHBP1 has high homology to tumour suppressor MCC1 (mutated in colon cancer-1).MCC2 protein binds the first PDZ domain of AIE-75 (also known as Harmonin) with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumour suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75 [ , ].
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Protein Domain
IPR032511
Name: Protein of unknown function DUF4971
Type: Family
Description: This small family consists of uncharacterised proteins mainly found in various Bacteroides species. The function of this protein is unknown.
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Protein Domain
IPR019534
Name: Protein of unknown function DUF2452
Type: Family
Description: This entry contains proteins that have no known function.
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Protein Domain
IPR032510
Name: Protein of unknown function DUF4972
Type: Family
Description: This family consists of uncharacterised proteins around 490 residues in length from various Bacteroides specie. The function of this protein is unknown.
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Protein Domain
IPR007563
Name: Protein of unknown function DUF554
Type: Family
Description: This is a family of uncharacterised prokaryotic proteins. Multiple predicted transmembrane regions suggest that the protein is membrane associated.
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Protein Domain
IPR032505
Name: Non-structural protein NSP4, C-terminal, coronavirus
Type: Domain
Description: This is the C-terminal domain of the coronavirus non-structural protein NSP4. NSP4 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. It is a membrane-spanning protein which is thought to anchor the viral replication-transcription complex (RTC) to modified endoplasmic reticulum membranes [ ]. This predominantly α-helical domain is involved in protein-protein interactions []. It has been shown that in betacoronavirus, the coexpression of NSP3 and NSP4 results in a membrane rearrangement to induce double-membrane vesicles (DMVs) and convoluted membranes (CMs), playing a critical role in SARS-CoV replication. There are two well conserved amino acid residues (H120 and F121) in NSP4 among betacoronavirus, which were demonstrated to be essential for membrane rearrangements during interaction with NSP3. This suggests that the specific details of the interaction between these two proteins varies among different coronavirus [, ].
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Protein Domain
IPR032502
Name: Protein of unknown function DUF4979
Type: Family
Description: This family consists of uncharacterised proteins around 450 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.
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Protein Domain
IPR020519
Name: Divergent protein kinase domain 2A/B
Type: Family
Description: DIPK2A, also known as DIA1 (deleted in autism protein 1), may play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade [ ]. This entry also includes DIPK2B, whose function is not clear.
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Protein Domain
IPR007548
Name: Protein of unknown function DUF505
Type: Family
Description: This is a family of uncharacterised prokaryotic proteins.
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Protein Domain
IPR007546
Name: Protein of unknown function DUF503
Type: Family
Description: This is a family of conserved hypothetical bacterial proteins, including TT1725 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579), which has a ferredoxin-like alpha+β-sandwich fold [ ].
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Protein Domain
IPR007544
Name: Type 1 encapsulin shell protein
Type: Family
Description: This protein family includes Type 1 encapsulin shell proteins found in prokaryotes. These proteins form nanocompartments within the bacterium which contain ferritin-like proteins or peroxidases, enzymes involved in oxidative-stress response. These enzymes are targeted to the interior of encapsulins via unique C-terminal extensions [ ].
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Protein Domain
IPR020500
Name: Anti-RecBCD protein 2, bacteriophage P22
Type: Family
Description: This phage protein modulates the activity of the host recBCD nuclease promoting phage growth and recombination and protects the linear double stranded DNA from exonuclease degradation [ , ].
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Protein Domain
IPR020504
Name: Protein of unknown function DUF5500
Type: Family
Description: This is a family of unknown function found in Herpesvirus. The family includes uncharacterized protein UL19.
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Protein Domain
IPR020507
Name: Protein of unknown function DUF5517
Type: Family
Description: This is a family of unknown function found in Fuselloviridae. Structure analysis suggest a role in viral assembly.
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Protein Domain
IPR029143
Name: Protein of unknown function, YrpD
Type: Family
Description: This entry represents bacterial proteins that are typically between 236 and 351 amino acids in length. The member from Bacillus subtilis is named YrpD (UniProtKB: ).
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Protein Domain
IPR032791
Name: Uncharacterised protein YhfZ, C-terminal domain
Type: Domain
Description: This domain is found in YhfZ proteins from Escherichia coli and Shigella flexneri. The crystal structure of this proteins is known ( ). This domain is often found in association with a helix-turn-helix domain.
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Protein Domain
IPR029147
Name: Cilia- and flagella-associated protein 77
Type: Family
Description: Proteins in this entry have been found in flagella [ ].
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Protein Domain
IPR005187
Name: Influenza C non-structural protein NS1
Type: Domain
Description: The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment encodes a 286 amino acid non-structural protein NS1 [ ]. This protein contains 6 conserved cysteines that may be functionally important, perhaps binding to a metal ion.
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Protein Domain
IPR005188
Name: Influenza C non-structural protein NS2
Type: Domain
Description: The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment encodes a 286 amino acid non-structural protein NS1 as well as the NS2 protein. The NS2 protein is only about 60 amino acids in length and of unknown function.
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Protein Domain
IPR029134
Name: Protein of unknown function DUF4647
Type: Family
Description: This entry represent a group of uncharacterised eukaryotic proteins. They are typically between 282 and 480 amino acids in length.
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Protein Domain
IPR029138
Name: snRNA-activating protein complex subunit 5
Type: Family
Description: snRNA-activating protein complex subunit 5 (also known as SNAPC5 or SNAPc19) is part of the core components of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes [ ]. The RNA polymerase II snRNA promoters consist of a proximal sequence element (PSE), while the RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. SNAPc binds to the PSE in both RNA polymerases and other PSE sequences in other snRNA genes. Therefore, SNAPc is also called the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAPc19 and SNAPc45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAPc190, SNAPc43 and SNAPc50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialised regulatory roles for snRNA gene transcription [ ].
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Protein Domain
IPR017167
Name: Uncharacterised conserved protein UCP037291, glutaredoxin-related
Type: Family
Description: This group represents a glutaredoxin-related protein, HI0926 type.
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Protein Domain
IPR030127
Name: I-BAR domain containing protein MTSS1/MTSS2
Type: Family
Description: This entry represents a subgroup of I-BAR (Bin/amphipysin/Rvs) domain-containing proteins, including MIM (MTSS1) and MTSS2 (also known as ABBA or MTSS1-like). BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [ ]. Most I-BAR proteins, including MIM and MTSS2, have an additional C-terminal WH2 domain, which binds G-actin [, , ].
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Protein Domain
IPR032771
Name: Protein of unknown function DUF4527
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates.
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Protein Domain
IPR029188
Name: Ribosomal RNA-processing protein 14, N-terminal
Type: Domain
Description: This entry represents the N-terminal domain of the Rrp14 (ribosomal RNA-processing protein 14) protein. Saccharomyces cerevisiae Rrp14 interacts with proteins involved in ribosomal biogenesis and cell polarity [ ]. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [, ].
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Protein Domain
IPR042158
Name: PI-PLC X domain-containing protein 1/2/3
Type: Family
Description: This entry includes phosphatidylinositol-specific phospholipase C X domain containing 1 (PI-PLCXD1), 2 (PI-PLCXD2) and 3 (PI-PLCXD3), which are bacterial phosphatidylinositol-specific phospholipase C (PI-PLC, ) sequence homologs found in animals. The typical eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, ) has a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. The catalytic core domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. In contrast, members in this group contain a single TIM-barrel type catalytic domain, X domain, and are more closely related to bacterial PI-PLCs, which participate in Ca2+-independent PI metabolism, hydrolyzing the membrane lipid phosphatidylinositol (PI) to produce phosphorylated myo-inositol and diacylglycerol (DAG). Although the biological function of eukaryotic PI-PLCXDs still remains unclear, it may distinct from that of typical eukaryotic PI-PLCs [ , , , ].
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Protein Domain
IPR029191
Name: Up-regulated during septation protein 1
Type: Domain
Description: This entry represents a domain found in fungal proteins, including Uds1 (Up-regulated During Septation 1) from Schizosaccharomyces pombe. Uds1 is involved in septation [ ]. Many of the uncharacterised proteins with this domain are listed as being involucrin repeat proteins, but this can not be substantiated.
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Protein Domain
IPR029178
Name: Extracellular mutant protein 11, C-terminal
Type: Domain
Description: This entry represents the C-terminal domain of Ecm11 (extracellular mutant protein 11). Ecm11 is a family of largely fungal proteins. Ecm11 is a component of the synaptonemal complex (SC), which is a protein structure that forms between homologous chromosomes during meiosis [ ]. It is required for efficient meiotic crossover and for the efficient assembly of the transverse filament protein, Zip1. Ecm11 is SUMOylated during meiosis. The SUMOylation of Ecm11 almost completely requires Gmc2 (another SC subunit), and is also dependent, to a lesser extent, on Zip1, Zip2, Zip4 and Spo16 [].
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Protein Domain
IPR029167
Name: Meiotically up-regulated gene 117 protein
Type: Family
Description: This protein was identified as being up-regulated during meiosis in Schizosaccharomyces pombe, where it is required for correct meiotic chromosome segregation [ ]. This family of proteins is found in largely in plants and fungi. Proteins in this family are typically between 128 and 920 amino acids in length.
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Protein Domain
IPR029169
Name: PEST proteolytic signal-containing nuclear protein
Type: Family
Description: PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein probably involved in cell cycle regulation [ ]. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation []. NIRF and PCNP may constitute a novel signaling pathway with some relation to cell proliferation.
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Protein Domain
IPR017173
Name: Nuclear mRNA export protein Sac3
Type: Family
Description: This entry represents a mRNA export factor Sac3 from budding yeasts. Sac3 is a component of the TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p), which functions in transcription elongation and transcription-coupled mRNA export from the nucleus to the cytoplasm [ , , ]. Its N terminus associates with Thp1 and Sem1 to form an mRNA-binding module, as well as with the export receptor Mex67, its C terminus interacts with Sus1, Cdc31 and the Nup1 nucleoporin, providing anchoring to the nuclear pore complex [ ].
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Protein Domain
IPR029171
Name: Protein of unknown function DUF4638
Type: Family
Description: This entry represents a group of eukaryotic proteins that are typically between 240 and 272 amino acids in length. Their function is not known.
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Protein Domain
IPR029158
Name: Stimulator of interferon genes protein
Type: Family
Description: Transmembrane protein 173, also known as stimulator of interferon genes protein (STING) or endoplasmic reticulum interferon stimulator (ERIS), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA [ , , , ]. In addition to promote the production of type I interferons, members of this family play a direct role in autophagy [, ].
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Protein Domain
IPR042125
Name: Small integral membrane protein 11
Type: Family
Description: This entry includes small integral membrane protein 11A and 11B from vertebrates. The function of these proteins is not clear.
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Protein Domain
IPR044784
Name: BTB/POZ domain containing protein At1g01640-like
Type: Family
Description: This is a group of plant BTB/POZ domain-containing proteins including At1g01640, At5g48510 and At3g56230 from Arabidopsis. They may act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [ ].
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Protein Domain
IPR029194
Name: Lens epithelial cell protein LEP503
Type: Family
Description: This protein may be involved in lens epithelial cell differentiation [ , ].
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Protein Domain
IPR029196
Name: HUWE1-associated protein modifying stress responses-like
Type: Family
Description: This entry represents the HUWE1-associated protein modifying stress responses (HAPSTR1, also known as telomere attrition and p53 response 1 protein (TAPR1) from eukaryotes, including TAPR1 from human, which is a key multistress-responsive protein that functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. It functions in cooperation with the E3 ubiquitin ligase HUWE1 which also promotes TAPR1's degradation [ , ]. This family also includes the uncharacterised proteins from fungi, such as YJR056C from yeast.
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Protein Domain
IPR040308
Name: HUWE1-associated protein modifying stress responses
Type: Family
Description: This entry represents the HUWE1-associated protein modifying stress responses (HAPR1, also known as TAPR1, telomere attrition and p53 response 1 protein) from animals, including HAPSTR1 (also known as C16orf72/TAPR1) from human, which functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. It may attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 [ , ].
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Protein Domain
IPR007800
Name: Protein of unknown function DUF693
Type: Family
Description: This family consists of uncharacterised proteins from Borrelia burgdorferi.
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