GO Term : GO:0008385 IkappaB kinase complex Gene Ontology

Description  A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Namespace  cellular_component
Obsolete  false

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0 Data Sets

1 Ontology

Trail: GOTerm

0 Ontology Annotations

12 Parents

Trail: GOTerm

12 Relations

Trail: GOTerm

3 Synonyms

Trail: GOTerm
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