GO Term : GO:0070765 gamma-secretase complex Gene Ontology
Description  A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the amyloid-beta precursor protein.
Namespace  cellular_component
Obsolete  false
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1 Ontology

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