GO Term : GO:1990306 RSP5-BUL ubiquitin ligase complex Gene Ontology
Description  A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation.
Namespace  cellular_component
Obsolete  false
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Trail: GOTerm

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