Protein Domain : Mitochondria-eating protein IPR026169

Type  Family
Description  Mitochondria-eating protein (MIEAP, also known as spermatogenesis-associated protein 18), a p53-inducible protein, is a key regulator of mitochondrial quality that mediates the repair or degradation of unhealthy mitochondria in response to mitochondrial damage [ ]. It induces intra-mitochondrial lysosome-like organella that eliminate oxidised mitochondrial proteins without destroying the mitochondrial structure, leading to improvement in mitochondrial function []. It is also involved in degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade the mitochondria by accumulating lysosomes [].
Short Name  MIEAP

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

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USDA
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