LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic- metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group,these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen,sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds. Five mammalian forms of FMO are now known and have been designatedFMO1-FMO5 [ , , , , ].FMO4 mRNA is present in low abundance in several foetal and adult tissues and the corresponding gene thus appears to be expressed constitutively [].Sequence analysis reveals that FMO4 is 56% identical to FMO3; each is encoded by a single gene []. The deduced amino acid sequence of human FM04 includes the putative FAD- (GxGxxG) and NADP +pyrophosphate-binding (GxGxxA) sites characteristic of mammalian FMOs, a 'FATGY' motif that has also beenobserved in a range of siderphore biosynthetic enzymes [ ], and a C-terminalhydrophobic segment that is believed to anchor the monooxygenase to the microsomal membrane []. |
| Short Name | Flavin_mOase_4 |
