Protein Domain : Misato Segment II tubulin-like domain IPR019605

Type  Domain
Description  The misato protein contains three distinct, conserved domains, segments I, II and III and is involved in the regulation of mitochondrial distribution and morphology [ ]. This entry represents misato segment II.Segments I and III are common to tubulins ( ), but segment II aligns with myosin heavy chain sequences from Drosophila melanogaster (Fruit fly, ), rabbit ( ), and human. Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it shares homology with a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail α-helical coiled-coils [ ].
Short Name  Misato_II_tubulin-like

0 Child Features

1 Gene Families

6 Genes

0 Ontology Annotations

0 Parent Features

4 Publications

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