GO Term : GO:0086095 positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate Gene Ontology

Description  A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate.
Namespace  biological_process
Obsolete  false

0 Cross References

0 Data Sets

1 Ontology

Trail: GOTerm

0 Ontology Annotations

111 Parents

Trail: GOTerm

131 Relations

Trail: GOTerm

5 Synonyms

Trail: GOTerm
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