Protein Domain : Vacuolar protein sorting-associated protein 35 IPR005378

Type  Family
Description  This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes. Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [ , ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease [ ]. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid [].
Short Name  Vps35

0 Child Features

2 Gene Families

21 Genes

3 Ontology Annotations

0 Parent Features

4 Publications

USDA
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