GO Term : GO:0007249 I-kappaB kinase/NF-kappaB signaling Gene Ontology

Description  The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Namespace  biological_process
Obsolete  false

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1 Data Sets

Trail: GOTerm

1 Ontology

Trail: GOTerm

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12 Parents

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31 Relations

Trail: GOTerm

6 Synonyms

Trail: GOTerm
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