LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [ , ].PLC-delta-1 is required for the maintenance of skin homeostasis. It functions as a calcium amplifier within the cell and is essential in trophoblasts for placental development. It is involved in Alzheimer's disease and hypertension. Furthermore, it regulates cell proliferation and cell-cycle progression [ , , , ]. Both PLC-delta-1 and PLC-delta-3 are essential in trophoblasts for placental development [].This entry represents the catalytic domain of PLC-delta1, a TIM barrel with two highly conserved regions (X, , and Y, ) split by a highly degenerate linker sequence [ ]. |
| Short Name | PLC-delta1_cat |
