LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | Galanin is involved in a variety of physiological mechanisms and disease states, from appetite and neuroregeneration to seizures and pain [ , ]. The actions of galanin are mediated through interaction with specific membrane receptors. Three receptor subtypes have been identified; Galanin receptor 1 (GALR1), Galanin receptor 2 (GALR2) and Galanin receptor 3 (GAL3), all of which are rhodopsin-like GPCRs. They differ from one another in terms of their expression patterns, affinity for various peptide analogues and G protein-coupling specificity [, , ]. In signaling, all can act via the Gi/o class [], whilst GAL2 also has Gq/11 as a major signaling route []. Galanin receptors are widely distributed in a wide range of central nervous system (CNS), peripheral tissues and in the endocrine, mirroring the distribution of galanin [ , ]. Galanin receptors mediate a variety of physiological functions including inhibition of glucose-induced insulin secretion [], stimulation of growth hormone release [] and modulation of gastrointestinal motility []. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes and feeding [, ]. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions, suggesting a role in the development and/or pathology of certain diseases. These include Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer [, , ]. This entry represents galanin receptor 3 subtype, which is expressed abundantly in the periphery and at lower levels in the CNS. In the brain, the highest levels have been found in the hypothalamus and pituitary [ ]. Expression has also been detected in peripheral tissues, including the pancreas, liver, kidney, stomach, adrenal gland, lung and spleen []. |
| Short Name | Galnin_3_rcpt |
