GO Term : GO:1990303 UBR1-RAD6 ubiquitin ligase complex Gene Ontology

Description  A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
Namespace  cellular_component
Obsolete  false

0 Cross References

0 Data Sets

1 Ontology

Trail: GOTerm

0 Ontology Annotations

6 Parents

Trail: GOTerm

6 Relations

Trail: GOTerm

1 Synonyms

Trail: GOTerm
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