Protein Domain : Chordopoxvirus fusion protein/multifunctional envelope protein A27 IPR003436

Type  Family
Description  This is a family of viral fusion proteins from the Chordopoxvirinae. A 14kDa Vaccinia virus protein has been demonstrated to function as a viral fusion protein mediating cell fusion at endosmomal (low) pH [ ]. The protein, found in the envelope fraction of the virions, is required for fusing the outermost of the two golgi-derived membranes enveloping the virus with the plasma membrane, and its subsequent release extracellularly. The N-terminal proximal region is essential for its fusion ability. More recently it has been shown that A27 forms disulfide-linked protein complexes with A26 protein providing an anchor for A26 protein packaging into mature virions. A27 regulates virion-membrane fusion rather than inducing it and is critical for the successful egress of mature virus particles [ ].
Short Name  Chordopox_Fusion/A27

0 Child Features

0 Gene Families

1 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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