Protein Domain : NAD biosynthesis/regulator protein NadR IPR016429

Type	Family
Description	NadR functions as a transcriptional regulator in Salmonella enterica [ ]. When NAD+ is available, NadR is bound with its corepressor, NAD+, and this leads to DNA binding activity that acts as a repressor for several genes needed for de novo NAD+ biosynthesis [, ]. NadR also possesses both NMN adenylyltransferase (NMNAT) and nicotinamide ribonucleoside kinase (RNK) activity []. Haemophilus influenzae lacks de novo biosynthetic pathways for NAD+ and also lacks a helix-turn-helix DNA binding domain present in NadR of S. enterica. H. influenzae NadR does not function as a repressor, but has enzymatic activity. Nicotinamide riboside (NR) enters the NAD+ resynthesis pathway after uptake, it is phosphorylated to obtain NMN by a nicotinamide RNK activity, and subsequently, NAD+ is synthesized from NMN and ATP via an NMNAT activity [ ]. NadR is a multifunctional biosynthesis/regulator protein.
Short Name	NAD_NadR