Protein Domain : YcaO-like domain IPR003776

Type	Domain
Description	This domain comprises the whole of a protein in Methanocaldococcus jannaschii and Methanobacterium thermoautotrophicum, all but the N-terminal 60 residues from a protein of Mycobacterium tuberculosis, and all but the C-terminal 180 residues from a protein in Haemophilus influenzae and Escherichia coli, among proteins from published complete genomes. This domain contains a conserved ATP-binding pocket [ ]. The domain can be found in Escherichia coli YcaO, which is known to be involved in beta-methylthiolation of ribosomal protein S12 [ ]. YcaO-like domains have been shown to be catalytically active, and to use ATP to activate amide backbones during peptide cyclodehydrations []. It is likely to be involved in post-translational modification (PTM) of amino acid residues. In Methanopyrus kandleri and Methanocaldococcus jannaschii YcaO is involved in thioamidation [].
Short Name	YcaO-like_dom