Protein Domain : Glucokinase regulatory protein, conserved site IPR005486

Type	Conserved_site
Description	The glucokinase regulatory protein (GCKR) [ ] is a vertebrate protein thatinhibits glucokinase by forming a complex with the enzyme, which plays a role in the control of blood glucose homeostasis. GCKR is a protein of about 70 Kdwhich is evolutionary related to bacterial N-acetylmuramic acid 6-phosphate etherases (MurNAc-6-P etherase, murQ), which are about half the size of GCKRand form active homodimers. MurNAc-6-P etherases catalyse the cleavage of the D-lactyl ether substituent of the bacterial cell wall sugar MurNAc and play arole in recycling of the cell wall [ ]. The 3D structure of the Haemophilusinfluenzae HI0754/murQ protein shows structural relationships with other sugar isomerase (SIS) domain proteins. Incontrast to mono-SIS bacterial MurNAc-6-P etherase, mammalian GCKR is composed of two SIS domains.
Short Name	Glucokinase_regulatory_CS