Protein Domain : Solute-binding protein family 5, conserved site IPR023765

Type	Conserved_site
Description	Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [ , ]. On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [ ] into eight families or clusters, which generally correlate with the nature of the solute bound. This entry represents a conserved site found in the extracellular solute-binding protein family 5 members from Gram-positive bacteria, Gram-negative bacteria and archaea.Family 5 members include: Periplasmic oligopeptide-binding proteins (gene oppA) of Gram-negative bacteria and homologous lipoproteins in Gram-positive bacteria (genes oppA, amiA or appA). Periplasmic dipeptide-binding proteins of Escherichia coli (gene dppA) and of Bacillus subtilis (gene dppE). Periplasmic murein peptide-binding protein of E. coli (gene mppA). Periplasmic peptide-binding proteins sapA of E. coli, Salmonella typhimurium and Haemophilus influenzae. Periplasmic nickel-binding protein (gene nikA) of Escherichia coli. Heme-binding lipoprotein (gene hbpA or dppA) from H. influenzae. Lipoprotein xP55 from Streptomyces lividans. H. influenzae hypothetical protein HI0213. Hypothetical protein y4tO from Rhizobium sp. strain NGR234 symbiotic plasmid. Hypothetical protein y4wM from Rhizobium strain NGR234 symbiotic plasmid.
Short Name	SBP_5_CS