v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Gingipains are proteinases from Porphyromonas gingivalis, a major pathogen associated with chronic periodontitis. They belong to MEROPS peptidase family C25. There are three types: Arg-specific proteinases RgpA, and RgpB, and the Lys-specific proteinase Kgp. All three gingipain precursors contain a propeptide of around 200 amino acids in length that is removed during maturation. It has been shown that gingipain propeptides are capable of inhibiting their mature cognate proteinases [ ]. Proteins homologous to the gingipain precursor are known from many other bacteria, some archaea and some eukaryotes. |
| Short Name | Propeptide_C25 |