Protein Domain : Gingipain propeptide IPR012600

Type  Domain
Description  Gingipains are proteinases from Porphyromonas gingivalis, a major pathogen associated with chronic periodontitis. They belong to MEROPS peptidase family C25. There are three types: Arg-specific proteinases RgpA, and RgpB, and the Lys-specific proteinase Kgp. All three gingipain precursors contain a propeptide of around 200 amino acids in length that is removed during maturation. It has been shown that gingipain propeptides are capable of inhibiting their mature cognate proteinases [ ]. Proteins homologous to the gingipain precursor are known from many other bacteria, some archaea and some eukaryotes.
Short Name  Propeptide_C25

0 Child Features

0 Gene Families

2 Genes

1 Ontology Annotations

0 Parent Features

1 Publications

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