LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Membrane contacts sites (MCSs), regions where two organelles come in close proximity to one another, act as molecular hubs for the exchange of smallmolecules (e.g. lipids) and signals (e.g. calcium ions). Synaptotagmin-like Mitochondrial lipid-binding Proteins (SMP) domains are exclusively found atMCSs between different organelles such as endoplasmic reticulum (ER)- Mitochondrion, ER-Plasma membrane (PM) and Nucleus-Vacuole junctions. The SMPdomain is able to homo- or heterodimerize, harbors lipids in a hydrophobic cavity and mediates lipid transfer between the two adjacent bilayersindependently of membrane fusion and fission reactions. SMP proteins are widespread amongst eukaryotic species with a particular enrichment in plantsand features suggestive of species-specific functional variations. SMP domain- containing proteins have been classified into four broad groups: C2 domainsynaptotagmin-like, PH domain-containing HT-008, PDZK8 and mitochondrial protein families [, , , , , ].The SMP domain consists of 6 β-strands and 3 helices arranged to form a barrel whose interior is lined almost exclusively by hydrophobic residues. The resulting elongated barrel-shaped cylindrical structureharbors a lateral opening and a central hydrophobic cavity where phospholipids can bind. It dimerizes in an anti-parallel fashion to form a cylindertraversed by a deep hydrophobic groove [ , , ]. The SMP domain belongs to theTULIP (for TUbular LIPid-binding) protein superfamily of lipid transfer proteins []. |
| Short Name | SMP_LBD |
