Protein Domain : Migration and invasion-inhibitory protein IPR031466

Type  Family
Description  Migration and invasion-inhibitory protein (MIIP or IIp45) binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells [ ]. MIIP attenuates mitotic transition, thereby inhibiting glioma progression [ ]. It not only modulates IGFBP-2, but also inhibits cell migration by binding to and inhibiting HDAC6, a class 2 histone deacetylase that deacetylates alpha-tubulin [].
Short Name  MIIP

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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