Protein Domain : Yeast cell wall synthesis Kre9/Knh1-like, N-terminal IPR018466

Type	Domain
Description	This domain is found at the N-terminal of a group of cell wall synthesis proteins, such as Knh1 and Kre9 from budding yeast, involved in cell wall beta 1,6-glucan synthesis. Kre9 is also involved in cell wall beta-glucan assembly [ ]. In Saccharomyces cerevisiae, a kre9 null mutation leads to severe growth defects, aberrant multi-budded morphology, and mating defects [, ]. Over-expression of Knh1 suppresses growth defects of a kre9 null mutant []. Knh1 is required for propionic acid resistance []. In Aspergillus fumigatus, proteins containing this domain play a role in fungal cell wall organisation []. This entry includes proteins from Lentinula edodes, involved in fruiting body formation, and may have a more general role in signalling in other organisms as it interacts with MAPK []. This entry also includes uncharacterised proteins from fission yeast, archaea and bacteria.
Short Name	Kre9/Knh1-like_N