Protein Domain : Coiled-coil domain-containing protein 89-like IPR043450

Type	Family
Description	This entry represents coiled-coil domain-containing protein 89 (CCDC89) and tumor suppressor candidate gene 1 protein (TUSC1).Hairy-related transcription factor (HRT), also known as Bc8, is a transcriptional repressor and has been identified as effector of the Notch signalling pathway. HRT proteins contain a conserved amino acid domain, denoted either as the Orange domain or as helix III/IV located at the C-terminal after the bHLH domain that is characteristic of all HES/E(spl)-related proteins, also referred to as bHLH-Orange (bHLH-O) proteins.Coiled-coil domain-containing protein 89 (CCDC89), also known as Bc8 orange-interacting protein (BOIP), interacts with the orange domain of HRT1. BOIP binds to the orange domain of HRT1/Hey1 and is predominantly expressed at a specific stage in spermatogenesis. BOIP may play a role in the maturation process from haploid round spermatids to spermatozoa, possibly as a tissue-specific regulator of HRT1/Hey1 activity [ ].Tumor suppressor candidate 1 (TUSC1) has been identified as a potential tumor suppressor in human cancers and could be a novel therapeutic target for glioblastoma [ ].
Short Name	CCDC89-like