Protein Domain : Peptide N glycanase, PAW domain IPR006588

Type	Domain
Description	The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C terminus of metazoan peptide:N-glycanase (PNGase)and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [ ]. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [].The PAW domain is a slightly elongated molecule and displays a β-sandwich architecture, which is composed of two layers, containing nine and eightantiparallel β-strands, respectively, and three additional short helices [ ].Some proteins known to contain a PAW domain are listed below:Animal peptide:N-glycanase (PNGase) , catalyses the deglycosylation of several misfolded N-linked glycoproteins by cleaving thebulky glycan chain before the proteins are degraded by the proteasome. Caenorhabditis elegans putative uncharacterised protein C17B7.5.
Short Name	Peptide_N_glycanase_PAW_dom