Protein Domain : C2H2-type zinc-finger protein GLI-like IPR043359

Type	Family
Description	This entry includes a group of zinc finger transcription regulators, including GLI1-3 and GLIS1-3 from humans.GLI1-3 are central effectors of the Hedgehog (Hh) pathway in vertebrates [ , ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions [ ]. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ].GLIS1-3 play key roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Glis1-3 share a highly homologous zinc finger domain (ZFD) containing five Cys2-His2-type zinc finger (ZF) motifs with members of the Gli and Zic family [ ].
Short Name	GLI-like