Protein Domain : E3 ubiquitin-protein ligase RING1/RING2 IPR043540

Type  Family
Description  E3 ubiquitin-protein ligase RING1 ( ) is one of the three E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, which is a specific tag for repression of epigenetic transcription and particularly for inactivation of chromosome X of female mammals [ , ]. RING1 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, the repressive BCOR complex [], and the the E2F6.com-1 complex in G0 phase []. RING1 has a RING-type zinc finger.E3 ubiquitin-protein ligase RING2 ( ) mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub) [ ], which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals []. RING2 is a component of the PRC1 complex [], and other chromatin-associated Polycomb (PcG) complexes such as BCOR []. It is also a component of the MLL1/MLL complex [].This entry includes E3 ubiquitin-protein ligase RING1/RING2.
Short Name  RING1/RING2

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